Displaying publications 1 - 20 of 25 in total

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  1. Fulltext OPTN/SRTR 2011 Annual Data Report: international data
    Kasiske BL, Skeans MA, Leighton TR, Ghimire V, Leppke SN, Israni AK
    Am J Transplant, 2013 Jan;13 Suppl 1:199-225.
    PMID: 23237702 DOI: 10.1111/ajt.12026
    For the first time, OPTN/SRTR has undertaken to publish global transplant rates as part of its Annual Data Report. Understanding why rates vary from country to country may lead to a better understanding of how to improve access to transplant everywhere. Availability of information varies substantially from country to country, and how complete and accurate the data are is difficult to ascertain. For Canada, Malaysia, and the United Kingdom, data were supplied at SRTR request from well-known registries. For many other countries, SRTR was unable to obtain information, and data from the World Health Organization's Global Observatory on Donation and Transplantation were used. Transplant counts and rates vary substantially around the world, likely due to 1) differences in rates of end-organ diseases, 2) economic differences in the ability to provide transplants or other end-organ disease treatment, 3) cultural differences that might support or hinder organ donation and transplant, and 4) reporting differences.
    Matched MeSH terms: Organ Transplantation*
  2. The unmet need of organ transplantation in Africa
    Awuah WA, Ng JC, Bulut HI, Nazir A, Tenkorang PO, Yarlagadda R, et al.
    Int J Surg, 2023 Mar 01;109(3):519-520.
    PMID: 36927835 DOI: 10.1097/JS9.0000000000000025
    Matched MeSH terms: Organ Transplantation*
  3. Current status of organ transplants in Asian countries
    Ota K
    Transplant Proc, 2004 Nov;36(9):2535-8.
    PMID: 15621082
    The Asian Society of Transplantation, founded in 1989 includes Indonesia, Japan, Korea, Malaysia, Oman, Pakistan, Republic of China, Philippines, Saudi Arabia, Singapore, Taiwan, Thailand, and the United Arab Emirates (UAE). The registry was also started from the same year in cooperation with these 16 countries. A questionnaire was sent to the key person of each country every year. The questionnaire includes (a) number of centers that performed organ transplants, (b) varieties and numbers of organ transplants performed in 2000 and 2001, (c) present status of dialysis, number of dialysis patients, and number of the candidates on the list for transplantation, (d) number of patients going abroad for transplantation, and (e) recent transplant highlights, news and issues affecting each country during 2000 and 2001. We previously gathered data for 2000, except for Indonesia, Singapore, and the UAE. Regarding 2001 data, we will send the questionnaires to the countries involved.
    Matched MeSH terms: Organ Transplantation/trends*; Organ Transplantation/statistics & numerical data
  4. Organ transplantation in Malaysia: a need for a comprehensive legal regime
    Kassim PN
    Med Law, 2005 Mar;24(1):173-89.
    PMID: 15887621
    Organ transplantation has become increasingly routine as a means of saving and improving the quality of lives of thousands of people each year. However, transplant activity is increasingly constrained by the shortage of organs. The major impediment in procuring organs for transplant in Malaysia is the lack of cadaveric donors. The lack of cadaveric donors has encouraged patients to go to countries like India and China to purchase organs especially kidneys for transplantation. The inadequacies of the existing Malaysian Human Tissues Act 1974 has also contributed to this problem. For instance, the word 'tissue" is not defined under the Act. This raises complex and ethical questions as to the scope of the definition for "tissue". There is also no definition of "the person lawfully in possession of the body." This is significant as he is the person who is empowered by the Act to authorise removal of tissue. Further, there is also no articulation of a hierarchy of relatives who are deemed the next of kin. In a situation involving a large number of relatives, asserting different opinions, this may pose a problem. The articulation of a priority list is particularly difficult in Malaysia as it is a multi-cultural society where the hierarchy of relatives with the right to claim decision-making powers may vary in different cultures. Furthermore, there is also a pressing need for a legislation to ensure that the rights of potential live donors are protected. At the moment, the Human Tissues Act 1974 only relates to cadaveric donors whereas live donors fall within the purview of the common law. The system of "opting out" should be considered in Malaysia whereby every individual is presumed to be a donor unless he or she registers an objection. But this system can only be fair if every person in the community is given notice of the law and understands its implications. For the system to work, there must also exist a simple and effective way of registering objections. There is a need for continuous intensive public education and counselling. A nationally co-ordinated mechanism must be in place to ensure effectiveness of identifying potential donors and recipients.
    Matched MeSH terms: Organ Transplantation/legislation & jurisprudence*
  5. Fulltext Socio-economic factors are the main factors affecting organ donation
    Li M, Li H, Azar AS
    Rev Assoc Med Bras (1992), 2023;69(10):e20230940.
    PMID: 37820179 DOI: 10.1590/1806-9282.20230940
    Matched MeSH terms: Organ Transplantation*
  6. Transcatheter vs Surgical Aortic Valve Replacement Outcomes Among Solid Organ Transplant Patients: A Systematic Review and Meta-Analysis
    Jaiswal V, Ang SP, Ishak A, Joshi A, Chia JE, Kalra K, et al.
    Curr Probl Cardiol, 2023 Aug;48(8):101685.
    PMID: 36931333 DOI: 10.1016/j.cpcardiol.2023.101685
    The safety and clinical outcomes of transcatheter aortic valve replacement (TAVR) compared to surgical aortic valve replacement (SAVR) among patients with solid organ transplants is not well understood. This study aimed to evaluate the clinical outcomes of TAVR and SAVR among patients with a history of solid organ transplantation. We performed a systematic literature search of databases for relevant articles from inception until May 1st, 2022. Unadjusted odds ratios (OR) were pooled using a random-effect model, and a P-value of <0.05 was considered statistically significant. A total of 3240 studies were identified of which 3 studies with a total of 2960 patients were included in the final analysis. For solid organ transplants patients, the odds of in-hospital mortality (OR 0.37, 95% CI 0.20-0.71, P < 0.001), 30-day mortality (OR 0.51, 95% CI 0.35-0.74, P < 0.001), acute kidney injury (OR 0.45, 95% CI 0.35-0.59, P < 0.001), and bleeding (OR 0.35, 95% CI 0.27-0.46, P < 0.001) were significantly lower in patients undergoing TAVR compared to SAVR. In contrast, the odds of pacemaker implantation (OR 2.60, 95% CI 0.36-18.90, P = 0.34), postprocedural stroke (OR 0.36, 95% CI 0.13-1.03, P = 0.06) were similar between both groups of patients. Length of hospital stay was significantly lower in TAVR compared to SAVR patients (SMD -0.82, 95% CI -0.95 to -0.70, P < 0.001). In solid organ transplant patients, TAVR appeared to be a safe procedure with fewer postprocedure complications, shorter length of hospital stay, and lower in hospital mortality compared with SAVR.
    Matched MeSH terms: Organ Transplantation*
  7. Ethical and legal issues in organ transplantation: Indian scenario
    Mathiharan K
    Med Sci Law, 2011 Jul;51(3):134-40.
    PMID: 21905567 DOI: 10.1258/msl.2011.010134
    In 1994, the Government of India enacted the Transplantation of Human Organs Act (THOA) to prevent commercial dealings in human organs. However, a greater number of scandals involving medical practitioners and others in the kidney trade has surfaced periodically in every state in India. The present regulatory system has failed mainly due to the misuse of Section 9(3) of the THOA, which approves the consent given by a live unrelated donor for the removal of organs for the reason of affection or attachment towards the recipient or for any other special reason. Currently in India, approximately 3500-4000 kidney transplants and 150-200 liver transplants are performed annually. However, the availability of organs from brain-dead persons is very low. As a result, live related or unrelated donors form the main source of organ transplantation. Therefore, physicians and policy-makers should re-examine the value of introducing regulated incentive-based organ donation to increase the supply of organs for transplantation and to end unlawful financial transaction.
    Matched MeSH terms: Organ Transplantation/legislation & jurisprudence*; Organ Transplantation/statistics & numerical data; Organ Transplantation/ethics*
  8. Fulltext National Transplant Registry
    Hooi LS, Lela Yasmin M
    Med J Malaysia, 2008 Sep;63 Suppl C:9-12.
    PMID: 19230241
    Matched MeSH terms: Organ Transplantation/statistics & numerical data*
  9. Criticizing the critique on the presumed consent system
    Tafran K
    Kidney Int, 2018 11;94(5):1023.
    PMID: 30348288 DOI: 10.1016/j.kint.2018.08.017
    Matched MeSH terms: Organ Transplantation
  10. Effect of diarrhoea on Tacrolimus trough level in a post liver transplant patient
    Tan ST, Yoong BK
    Med J Malaysia, 2020 11;75(6):734-735.
    PMID: 33219186
    Tacrolimus, which bonds to an immunophilin, FK506 binding protein (FKBP) has emerged as one of the most widely used immunosuppressant post solid organ transplantation. It offers excellent patient survival rates post-transplantation and a lesser number of acute rejections as compared to cyclosporine. Tacrolimus has a narrow therapeutic window with overexposure leading to acute and chronic forms of nephrotoxicity. Remarkably few data have been published on the overexposure to tacrolimus following mild diarrhoea in post-transplant patients who received treatment with tacrolimus. We observed a post-liver transplant patient with increased trough level of tacrolimus during severe diarrhoea with no complications following a timely adjustment on the dose of tacrolimus.
    Matched MeSH terms: Organ Transplantation
  11. Fulltext Willingness and Perceived Barriers towards Organ Donation among Student Nurses in Universiti Malaysia Sabah
    R. Segaran, Mohd Amsyar Bacho, Asrani Yaco
    Borneo Journal of Medical Sciences, 2018;12(101):67-68.
    MyJurnal
    Organ transplant has become a main stream important medical procedure commonly used in hospitals. However, for organ transplant programme to be successful, it heavily relies on the public to voluntarily register for organ procurement. Effort to promote awareness and register public as organ donors has been ongoing, but public response to commit and register as donors has been lukewarm. Arguably, healthcare personnel and nurses are in a key position to educate and advocate for organ donation but often, ironically healthcare personal themselves are reluctant or unwilling to commit as organ donors. Thus, in the context of student nurses in Universiti Malaysia Sabah (UMS), the question arises, what is their stance and views regarding organ donation.
    Matched MeSH terms: Organ Transplantation
  12. Review paper: Organ transplants: ethical, social, and religious issues in a multicultural society
    Robson NZ, Razack AH, Dublin N
    Asia Pac J Public Health, 2010 Jul;22(3):271-8.
    PMID: 20460294 DOI: 10.1177/1010539509357446
    Recent advances in the fields of organ donation and organ transplant have introduced new hope for the treatment of serious diseases. However, this promise has been accompanied by several issues. The most common issue raised is ethical implications, but in a multicultural society like Malaysia, additional concerns arise pertaining to social and religious issues. These concerns needs to be addressed as attitudes toward and acceptability of organ donation varies according to social, culture, and religion. The diverse cultural, religious, and traditional concepts pertaining to organ donation may hamper its acceptability and cause a lack of willingness to donate organs. The purpose of this article is to briefly explore the ethical issues involved in organ transplant and the various religious opinions on organ donation. It is hoped that this knowledge and understanding may benefit both health care providers and patients in a multicultural society like Malaysia.
    Matched MeSH terms: Organ Transplantation/ethics*
  13. Fulltext The health care professional's attitudes towards brain death and cadaveric organ transplantation: the influence of cadaveric donor and transplantation programs--a Malaysian survey
    Rozaidi SW, Sukro J, Dan A
    Med J Malaysia, 2000 Dec;55(4):478-85.
    PMID: 11221161
    One of the main reasons for poor response in organ donation is the lack of positive attitudes and knowledge present in health care professionals. Definite legislation, policies and programmes dealing with brain death and cadaveric organ transplantation have shown some favourable results in terms of increasing donor rates. These programmes are mainly Western based; therefore adopting such programmes to be used locally may not be adequate or proper. To address this issue, we decided to carry out a questionnaire in two tertiary hospitals in Malaysia, one with a well establish brain death and cadaveric organ transplantation programme and one with none.
    Matched MeSH terms: Organ Transplantation*
  14. Fulltext Prioritizing Factors Affecting Deceased Organ Donation in Malaysia: Is a New Organ Donation System Required?
    Naghavi N, Mubarik MS, Rasiah R, Sharif Nia H
    Int J Gen Med, 2020;13:641-651.
    PMID: 32982381 DOI: 10.2147/IJGM.S253372
    Purpose: The gap between the demand and the supply of human organs for transplantation is on the rise in Malaysia, despite the efforts of governments to promote donor registration. Factors affecting willingness to donate are contextual and vary from country to country. This research mainly focuses on the selection of most suitable organ donation system through factors affecting willingness to donate in Malaysia. The objectives of this study are to prioritize those factors acting as the pillars of the organ donation system and further to select the most suitable organ donation system for Malaysia.

    Patients and Methods: The data were collected from 35 experts by using a bipolar questionnaire. The study applied an analytical hierarchal process (AHP) for prioritization factors contributing to willingness to donate and then selection of a suitable organ donation system based on prioritized factors.

    Results: Based on the AHP results, it is evident that donation perception (0.36) has the highest priority in influencing organ donation rates, followed by socioeconomic status (0.32), demographic factors (0.23), and financial incentives (0.09). Further, our results challenge the existing opt-in donation system in Malaysia and present a presumptive approach as a suitable system for increasing deceased donation rate in Malaysia. Presumptive approach promotes the role of health-care professionals in securing the family consent.

    Conclusion: This approach is a person-oriented rather than process-oriented strategy and it relies on designated requesters' skills to evoke altruism among bereaved families. Based on results, the authors recommended that relevant government agencies focus on training nurses to discuss donation with bereaved families and raising public awareness.

    Matched MeSH terms: Organ Transplantation
  15. Fatal outcome of catheter-related bloodstream infection caused by Multidrug-Resistant Mycobacterium mucogenicum
    Faridah S, Siti Asma' H, Zeti NS, Tuan Noorkorina TK, Intan Baiduri B, Azura H
    Med J Malaysia, 2021 03;76(2):248-250.
    PMID: 33742638
    Mycobacteria mucogenicum (M. mucogenicum) is a rarely isolated pathogen. It has emerged as a significant pathogen in immunocompromised patients including those with cancer, organ transplant, or patients on immunosuppressive medication. Chemotherapy may reduce the ability of the bone marrow of these to respond to infection, and patients will be at risk for neutropenic sepsis, which leads to fatal complications. Here, we report a case of an 18-year-old boy was seen at Hospital Raja Perempuan Zainab II, Kelantan with acute lymphoblastic leukaemia (ALL) who presented with catheter-related bloodstream infection (CRBSI) caused by M. mucogenicum. He succumbed due to neutropenic sepsis with multiorgan failure.
    Matched MeSH terms: Organ Transplantation
  16. Factors Influencing Attitude Toward Organ and Tissue Donation Among Patients in Primary Clinic, Sabah, Malaysia
    Lim KJ, Cheng TTJ, Jeffree MS, Hayati F, Cheah PK, Nee KO, et al.
    Transplant Proc, 2020 Apr;52(3):680-686.
    PMID: 32146022 DOI: 10.1016/j.transproceed.2020.01.007
    INTRODUCTION: Worldwide, the gap between organ supply and demand has widened over the years. Malaysia has one of the lowest deceased organ donation rates. Success rate of organ or tissue procurement depends on not only the approach rate by health care providers but also the awareness among the public, whereby it can be a platform for family initiation of organ donation. The purpose of this study is to assess the knowledge of and determine the factors influencing attitude toward organ and tissue donation among patients in a primary clinic.

    METHODS: A cross-sectional analytical study was carried out. Self-administered questionnaires were given to 400 patients who registered at an outpatient clinic in April 2018. Convenience sampling was applied.

    RESULTS: Monthly income, education level, occupation, and knowledge level are significantly associated with attitude of the respondents toward organ and tissue donation. Occupation influenced attitude toward organ donation. Knowledge of organ donation and brain death both significantly affected attitude toward organ donation.

    CONCLUSION: The greater the knowledge of organ donation and brain death, the more positive impression or attitude toward organ donation. Education level and income are the main predictors that influence attitude toward organ donation. Hence, it is important for public health units to promote and deliver public education on organ donation, change public misconceptions, and work parallel with hospitals to increase organ donation rates in Sabah.

    Matched MeSH terms: Organ Transplantation/psychology*
  17. Islamic medical jurisprudence syllabus: A Review in Saudi Arabia
    Chamsi-Pasha H, Albar MA
    Med J Malaysia, 2017 10;72(5):278-281.
    PMID: 29197882
    INTRODUCTION: The ever-increasing technological advances of Western medicine have created new ethical issues awaiting answers and response. The use of genetic therapy, organ transplant, milk-banking, end-of-life care and euthanasia are of paramount importance to the medical students and need to be addressed.

    METHODS: A series of searches were conducted of Medline databases published in English between January 2000 and January 2017 with the following keywords: medical ethics, syllabus, Islam, jurisprudence.

    RESULTS: Islamic medical jurisprudence is gaining more attention in some medical schools. However, there is still lack of an organised syllabus in many medical colleges.

    CONCLUSION: The outlines of a syllabus in Islamic medical jurisprudence including Islamic values and moral principles related to both the practice and research of medicine are explored.

    Matched MeSH terms: Organ Transplantation/legislation & jurisprudence
  18. Fulltext PET-CT as an effective imaging modality in the staging and follow-up of post-transplant lymphoproliferative disorder following solid organ transplantation
    Noraini AR, Gay E, Ferrara C, Ravelli E, Mancini V, Morra E, et al.
    Singapore Med J, 2009 Dec;50(12):1189-95.
    PMID: 20087557
    To establish the role of positron-emission tomography (PET)-computed tomography (CT) in post-transplant lymphoproliferative disorder (PTLD) patients, compared to conventional imaging (ultrasonography/CT/magnetic resonance imaging) in relation to its accuracy, sensitivity and specificity.
    Matched MeSH terms: Organ Transplantation*
  19. Requirements for the development of a hand transplantation program
    Gordon CR, Siemionow M
    Ann Plast Surg, 2009 Sep;63(3):262-73.
    PMID: 19692900 DOI: 10.1097/SAP.0b013e31818d45e9
    Since 1998, 42 hand transplants in 30 patients have been performed in countries such as France, United States, China, Austria, Malaysia, Italy, Belgium, Poland, Spain, and Germany. Now, with recent improvements in immunosuppression, the clinical applicability may expand and the ethical obstacles may soon be overcome, allowing multiple US institutions to perform hand allotransplantation. The main purpose of this article is to facilitate access to pertinent details in regards to hand transplantation, such as donor/recipient selection criteria, immunosuppressive therapies, and associated complications. It is a comprehensive literature review compiled from published reports from multiple hand transplant programs throughout the world. Due to its inherent complexity, hand transplantation should only be attempted at institutions within the US capable of orchestrating a specialized multidisciplinary team, and each institution's protocol should be extremely detailed and individualized.
    Matched MeSH terms: Organ Transplantation/standards; Organ Transplantation/trends
  20. Fulltext Quantitative and qualitative evaluation of sural nerve graft donor site
    Ng SS, Kwan MK, Ahmad TS
    Med J Malaysia, 2006 Dec;61 Suppl B:13-7.
    PMID: 17600987
    This study is designed to evaluate twenty patients after sural nerve harvest using the single longitudinal incision method. The area of sensory loss to pin prick was assessed by the authors at different intervals. Donor site factors, scar cosmesis, functional status and complications were assessed using a questionnaire. The mean area of anaesthesia at one month was 65 cm2 and it had reduced by 77% to 15 cm2 at one and a half years. The mean area of reduced sensation was 49 cm2 at one month and it increased by 18% to 58 cm2 over the same period. Therefore, the total area of sensory deficit was reduced by 36% from 114 cm2 at one month to 73 cm2 at one and a half years. Subjective patient evaluation indicated moderate level of pain during immediate post surgical period, which reduced significantly at one month. A low level of neuroma symptoms was recorded throughout the study period. At a mean follow-up period of two years, there was no area of anaesthesia in 50% of the patients. Mean area of anaesthesia for all patients was 12 cm2 and mean area of reduced sensation was 55 cm2. Subjective patient evaluation indicated a low level of pain, neuroma symptoms and numbness over the sural nerve sensory distribution. Twenty five percent of the patients were not satisfied with the scar appearance. Function and daily activities were not affected significantly. No surgical complications were observed.
    Matched MeSH terms: Organ Transplantation/standards*
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