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  1. Riyanto, Jumat Salimon, Mohamed Rozali Othman
    Sains Malaysiana, 2007;36:175-181.
    Elektrod platinum-polivinilklorida (Pt-PVC) untuk pengoksidaan elektrokimia etanol dalam larutan alkali telah direkabentuk. Elektrod Pt-PVC dibina dengan mencampurkan serbuk-serbuk logam platinum dengan PVC (95:5 w/w), diaduk untuk mendapatkan campuran yang homogen, ditambahkan dengan tetrahidrofuran (THF) untuk melarutkan PVC, dikeringkan, dimasukkan ke dalam acuan berdiameter 1 cm dan ditekan pada tekanan kira-kira 10 tan/cm2. Kajian elektrokimia dilakukan menggunakan voltammetri kitaran (CV) dan kronokoulometri (CC). CV untuk etanol yang menggunakan elektrod-elektrod kepingan logam Pt dan Pt-PVC masing-masing memberikan ketumpatan arus 0.25 mA/cm2 dan 85 mA/cm2 untuk puncak penjerapan hidroksida. Ini menunjukkan bahawa elektrod Pt-PVC mempunyai nilai konduktiviti dan perilaku elektrokimia yang lebih baik untuk pengoksidaan etanol dalam KOH berbanding elektrod kepingan logam Pt. Hasil kajian mendapati bahawa terdapat peningkatan peratus hasil elektrolisis dari 3.64% kepada 23.64% asid asetik apabila elektrod Pt-PVC digunakan untuk pengoksidaan elektrokimia 0.25 M etanol dalam larutan elektrolit 1.0 M KOH menggantikan elektrod kepingan logam Pt.
    Matched MeSH terms: Receptor, Notch1
  2. Tukimat Lihan, Nur Fatin Khodri, Muzzneena Ahmad Mustapha, Zulfahmi Ali Rahman, Wan Mohd Razi Idris
    Sains Malaysiana, 2018;47:2241-2249.
    Aktiviti guna tanah di kawasan lembangan adalah salah satu faktor yang mendorong kepada kemerosotan kualiti air
    sungai akibat daripada hakisan tanih. Potensi hakisan tanih di kawasan lembangan Sungai Bilut, Raub, Pahang yang
    menjadi sumber bekalan air minuman utama di daerah Raub boleh ditentukan dengan menggunakan integrasi model
    Semakan Semula Persamaan Kehilangan Tanih Universal (RUSLE) dan Sistem Maklumat Geografi (GIS). Kajian ini
    bertujuan untuk menentukan potensi hakisan tanih dan faktor utama yang mempengaruhi kadar hakisan tanih. Kajian ini
    melibatkan penggunaan data sekunder yang terdiri daripada data hujan, data siri tanih dan topografi bagi menghasilkan
    faktor kehakisan hujan (R), kebolehhakisan tanih (K), serta panjang dan kecuraman cerun (LS). Faktor litupan tumbuhan
    (C) dan amalan pemuliharaan (P) pula dijana daripada imej satelit Landsat 8 (2014). Keputusan kajian menunjukkan
    nilai faktor R di kawasan kajian ialah 8927.68-9775.18 MJ mm ha-1 jam-1 tahun-1, nilai K ialah 0.036-0.500 tan jam-1
    MJ-1 mm-1, nilai LS ialah 0-514, nilai C ialah 0.03-0.80 dan nilai P ialah 0.1-0.7. Kawasan yang mempunyai potensi
    hakisan sangat rendah hingga rendah meliputi 81%, manakala potensi hakisan tanih sederhana hingga sangat tinggi
    meliputi 19% daripada keseluruhan kawasan kajian. Model yang dihasilkan mempunyai ketepatan sebanyak 81%. Faktor
    utama yang mempengaruhi berlakunya hakisan tanih di kawasan kajian adalah faktor topografi, litupan tumbuhan dan
    kebolehhakisan tanih. Keputusan menunjukkan analisis integrasi RUSLE dan GIS berpotensi dalam penentuan potensi
    hakisan tanih untuk kawasan luas yang mempunyai pelbagai jenis guna tanah, topografi dan jenis tanih.
    Matched MeSH terms: Receptor, Notch1
  3. Kumar S, Fazil MHUT, Ahmad K, Tripathy M, Rajapakse JC, Verma NK
    Methods Mol. Biol., 2019;1930:149-156.
    PMID: 30610609 DOI: 10.1007/978-1-4939-9036-8_18
    Analysis of protein-protein interactions is important for better understanding of molecular mechanisms involved in immune regulation and has potential for elaborating avenues for drug discovery targeting T-cell motility. Currently, only a small fraction of protein-protein interactions have been characterized in T-lymphocytes although there are several detection methods available. In this regard, computational approaches garner importance, with the continued explosion of genomic and proteomic data, for handling protein modeling and protein-protein interactions in large scale. Here, we describe a computational method to identify protein-protein interactions based on in silico protein design.
    Matched MeSH terms: Receptor, Notch1/metabolism; Receptor, Notch1/chemistry
  4. Barakat SM, Siar CH
    J Appl Oral Sci, 2015 Jan-Feb;23(1):79-86.
    PMID: 25760270 DOI: 10.1590/1678-775720140245
    The identification of stem cells (SC) remains challenging. In the human oral mucosal epithelium, these cells are believed to be in the basal layer (stem cell niche), but their exact location is unclear. The aim of this study was to examine the dysplastic oral epithelium for these SC-like proteins in order to assess their diagnostic value as biomarkers complementing the histological grading of dysplasia.
    Matched MeSH terms: Receptor, Notch1/analysis
  5. Siar CH, Ha KO, Aung LO, Nakano K, Tsujigiwa H, Nagatsuka H, et al.
    Eur. J. Med. Res., 2010 Oct 25;15(10):456-60.
    PMID: 21156405
    BACKGROUND: notch receptors are critical determinants of cell fate in a variety of organisms. Notch signaling is involved in the chondrogenic specification of neural crest cells. Aberrant Notch activity has been implicated in numerous human diseases including cancers; however its role in chondrogenic tumors has not been clarified.

    METHOD: tissue samples from a case of primary chondrosarcoma of the maxilla and its recurrent tumor were examined immunohistochemically for Notch1-4 and their ligands (Jagged1, Jagged2 and Delta1) expression.

    RESULTS: both primary and recurrent tumors were histopathologically diagnosed as conventional hyaline chondrosarcoma (WHO Grade I). Hypercellular tumor areas strongly expressed Notch3 and Jagged1 in spindle and pleomorphic cells suggesting up-regulation of these protein molecules at sites of tumor proliferation. Expression patterns were distinct with some overlap. Differentiated malignant and atypical chondrocytes demonstrated variable expression levels of Jagged1, and weak to absent staining for Notch1, 4 and Delta1. Protein immunolocalization was largely membranous and cytoplasmic, sometimes outlining the lacunae of malignant chondrocytes. Hyaline cartilage demonstrated a diffuse or granular precipitation of Jagged1 suggesting presence of soluble Jagged1 activity at sites of abnormal chondrogenesis. No immunoreactivity for the other Notch members was observed. Calcified cartilage was consistently Notch-negative indicating down-regulation of Notch with cartilage maturation. Stromal components namely endothelial cells and fibroblasts variably expressed Notch1, 3 and Jagged1 but were mildly or non-reactive for the other members.

    CONCLUSIONS: Results indicate that Notch signaling pathway may participate in cellular differentiation and proliferation in chondrosarcoma. Findings implicate Notch3 and Jagged1 as key molecules that influence the differentiation and maturation of cells of chondrogenic lineage.

    Matched MeSH terms: Receptor, Notch1/metabolism
  6. Siar CH, Nakano K, Ng KH, Tomida M, Nagatsuka H, Kawakami T
    Eur. J. Med. Res., 2010 Apr 08;15(4):180-4.
    PMID: 20554499
    BACKGROUND: Squamous odontogenic tumor (SOT) is a rare benign odontogenic epithelial neoplasm. A slow-growing painless expansive swelling is the common presenting symptom. Histopathologically, SOT can be easily misdiagnosed as an acanthomatous ameloblastoma. Although Notch receptors and ligands have been shown to play a role in cell fate decisions in ameloblastomas, the role of these cell signaling molecules in SOT is unknown.

    CASE REPORT: This paper describes a case of SOT affecting the anterior mandible of a 10-year-old Indian female. The patient was treated by local surgical excision and there has been no follow-up clinical record of recurrence 5 years after primary treatment. Histo?pathological examination revealed a solid, locally-infiltrative neoplasm composed of bland-looking squamatoid islands scattered in a mature fibrous connective tissue stroma and the diagnosis was SOT. Immunohistochemical evaluation showed positive reactivity of varying intensity in the neoplastic epithelial cells for Notch1, Notch3, Notch4, and their ligands Jagged1 and Delta1. Expression patterns showed considerable overlap. No immunoreactivity was detected for Notch2 and Jagged2.

    CONCLUSIONS: Present findings suggest that Notch receptors and their ligands play differential roles in the cytodifferentiation of SOT.

    Matched MeSH terms: Receptor, Notch1/metabolism*
  7. Siar CH, Nakano K, Han PP, Nagatsuka H, Ng KH, Kawakami T
    J. Oral Pathol. Med., 2010 Aug 1;39(7):552-8.
    PMID: 20337864 DOI: 10.1111/j.1600-0714.2009.00871.x
    In mammals, the Notch gene family encodes four receptors (Notch1-4), and all of them are important for cell fate decisions. Notch signaling pathway plays an essential role in tooth development. The ameloblastoma, a benign odontogenic epithelial neoplasm, histologically recapitulates the enamel organ at bell stage. Notch has been detected in the plexiform and follicular ameloblastoma. Its activity in the desmoplastic ameloblastoma is unknown.
    Matched MeSH terms: Receptor, Notch1/analysis
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