MyMedR

Landor JV, Pallister R

Trans R Soc Trop Med Hyg, 1935;29:121-134.

I. A disease occurring in Malaya, particularly in institutions, is described. The main lesions in the early stage are eczema of the scrotum, eczema of the angles of the mouth and superficial glossitis. In the late stage the symptoms are those of combined degeneration of the cord and poor vision. A brief survey of the literature shows that symptoms of this type are widespread throughout the woHd.
2. The etiology is discussed and evidence given to show that the early stage is due to an avitaminosis B2 and that the late stage is probably due to a similar deficiency.

Matched MeSH terms: Vitamin B Deficiency

The nutritive value of rice

Rosedale JL

Journal of the Malaya Branch of the British Medical Association, 1939;3:213-27.

Matched MeSH terms: Vitamin B Deficiency

Fulltext Oral submucous fibrosis--an alternative hypothesis as to its causes

Ramanathan K

Med J Malaysia, 1981 Dec;36(4):243-5.

PMID: 7334962

Submucous fibrosis (SMF) an important precancerous condition occurs almost exclusively in Indians but cases have been reported from several countries throughout the world. The causes of SMF are unknown and there is no known treatment for it. Chillies, tobacco use, vitamin deficiencies and betel quid chewing have been implicated. Ramanathan is of the view that SMF seems to be the Asian version of sideropenic dysphagia. He suggests that SMF appears to be an altered oral mucosa following a prolonged period of chronic deficiency of iron and/or vitamin B complex especially folic acid. This changed state of the oral mucosa subsequently appears to develop more easily a hypersensz"tivity to oral irritants such as spices especially chillies and to the betel quid. He provides biochemical data as well as quotes several studies to support his hypothesis.

Matched MeSH terms: Vitamin B Deficiency/complications

Nicotinic acid content of foods

Leong PC

Journal of the Malaya Branch of the British Medical Association, 1940;4:261-78.

Matched MeSH terms: Vitamin B Deficiency

Neurologic Manifestations of Vitamin B Deficiency after Bariatric Surgery

Punchai S, Hanipah ZN, Meister KM, Schauer PR, Brethauer SA, Aminian A

Obes Surg, 2017 Aug;27(8):2079-2082.

PMID: 28213665 DOI: 10.1007/s11695-017-2607-8

INTRODUCTION: The aim of this study was to assess the incidence, clinical presentation, and outcomes of neurologic disorders secondary to vitamin B deficiencies following bariatric surgery.

METHODS: Patients at a single academic institution who underwent bariatric surgery and developed neurologic complications secondary to low levels of vitamins B1, B2, B6, and B12 between the years 2004 and 2015 were studied.

RESULTS: In total, 47 (0.7%) bariatric surgical patients (Roux-en-Y gastric bypass n = 36, sleeve gastrectomy n = 9, and duodenal switch n = 2) developed neurologic manifestations secondary to vitamin B deficiencies. Eleven (23%) patients developed postoperative anatomical complications contributed to poor oral intake. Median duration to onset of neurologic manifestation following surgery was 12 months (IQR, 5-32). Vitamin deficiencies reported in the cohort included B1 (n = 30), B2 (n = 1), B6 (n = 12), and B12 (n = 12) deficiency. The most common manifestations were paresthesia (n = 31), muscle weakness (n = 15), abnormal gait (n = 11), and polyneuropathy (n = 7). Four patients were diagnosed with Wernicke-Korsakoff syndrome (WKS) which was developed after gastric bypass (n = 3) and sleeve gastrectomy (n = 1). Seven patients required readmission for management of severe vitamin B deficiencies. Overall, resolution of neurologic symptoms with nutritional interventions and pharmacotherapy was noted in 40 patients (85%). The WKS was not reversible, and all four patients had residual mild ataxia and nystagmus at the last follow-up time.

CONCLUSIONS: Nutritional neurologic disorders secondary to vitamin B deficiency are relatively uncommon after bariatric surgery. While neurologic disorders are reversible in most patients (85%) with vitamin replacements, persistent residual neurologic symptoms are common in patients with WKS.

Matched MeSH terms: Vitamin B Deficiency/etiology*; Vitamin B Deficiency/epidemiology*; Vitamin B Deficiency/psychology

Clinical manifestations of vitamin deficiencies as observed in the Federated Malay States

Fasal P

Archives of Dermatology and Syphilology, 1944;50:160-166.

DOI: 10.1001/archderm.1944.01510150012002

Manifestations of vitamin deficiencies observed in 6,000 Tamil and 4,000 Malay children and young adults during a survey carried out by the Institute for Medical Research in the Federated Malay States included phrynoderma, Bitot spots
and angular stomatitis. They were more frequent in Tamils than in Malays. Phrynoderma and Bitot spots responded rapidly to administration of vitamin A or carotene, though in some patients with phrynoderma improvement was not attained unless also the protein intake was increased and vitamin B complex added. Angular stomatitis was benefited by administration of riboflavin or vitamin B complex. The clinical and histologie observations of phrynoderma in Tamils and Malays in Malaya were identical with those previously reported in Chinese, Ceylonese and southern Indians. A supplementary food ration, composed of soy beans, skim milk powder, dal and red palm oil, given to Tamil children on rubber estates not only increased the general state of health but led to a rapid regression of the manifestations of vitamin deficiencies.

Matched MeSH terms: Vitamin B Deficiency

Strachan's syndrome 30 years after onset

Byrne E, Horowitz M, Dunn DE

Med J Aust, 1980 May 31;1(11):547-8.

PMID: 6248745

While a prisoner-of-war in Malaya from 1942-1945, a 29-year-old man developed a painful sensorimotor neuropathy, bilateral central scotomata and sensorineural deafness. Examination 34 years later, after a long period of adequate nutrition, revealed considerable residual deficit. Nerve conduction studies suggested axonal degeneration with prominent collateral reinnervation. This case of Strachan's syndrome is reported to draw attention to the limited functional recovery and to focus attention on this condition at a time when famine conditions are rife in Southeast Asia.

Matched MeSH terms: Vitamin B Deficiency/complications

Fulltext Rapid resolution liquid chromatography method development and validation for simultaneous determination of homocysteine, vitamins B(6), B(9), and B(12) in human serum

Shaik MM, Gan SH

Indian J Pharmacol, 2013 Mar-Apr;45(2):159-67.

PMID: 23716893 DOI: 10.4103/0253-7613.108303

Hyperhomocysteinemia and vitamins B(6), B(9), and B(12) deficiencies usually result in various neurological, vascular, ocular, renal, and pulmonary abnormalities. However, to date, there are no simultaneous detection methods available for determining homocysteine, vitamins B(6), B(9), and B(12) levels in various biological fluids. In this study, we aim to develop a new validated simultaneous detection method for all four compounds to save both cost and time of analysis.

Matched MeSH terms: Vitamin B Deficiency/diagnosis

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