MyMedR

Walkingshaw R

Malayan Medical Journal, 1930;5:65.

Matched MeSH terms: Wound Healing

Which Beds, Overlays, and Mattresses Are Effective in Promoting Pressure Ulcer Healing?: A Cochrane Review Summary With Commentary

Engkasan JP

Am J Phys Med Rehabil, 2022 Oct 01;101(10):975-976.

PMID: 35067554 DOI: 10.1097/PHM.0000000000001974

Matched MeSH terms: Wound Healing

Wound healing in diabetes mellitus: traditional treatment modalities

Laitiff AA, Teoh SL, Das S

Clin Ter, 2010;161(4):359-64.

PMID: 20931161

The healing of wound is a complex process which requires the interactions of different cells and extracellular molecules. The normal wound healing process can be divided into four overlapping phases i.e. haemostasis, inflammation, proliferation and remodeling. In diseased condition like diabetes mellitus, the wound healing process is grossly impaired, resulting in chronic wounds which fail to heal. In the past decades, several researchers have tested various traditional medicines obtained from the plants for their wound healing properties. Such traditional plants are Aloe vera, Calotropis procera, Portulaca oleracea, Acalypha langiana, Plagiochasma appendiculatum and Momordica charantia. Perhaps one of the most popular and easily available plant is Momordica charantia (bitter gourd). The present article presents an extensive review on the impaired wound healing process in diabetes mellitus and highlights the use of traditional medicines in diabetic wounds.

Matched MeSH terms: Wound Healing*

Fulltext Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review

Naomi R, Bt Hj Idrus R, Fauzi MB

Int J Environ Res Public Health, 2020 09 18;17(18).

PMID: 32961877 DOI: 10.3390/ijerph17186803

Cellulose is a naturally existing element in the plant's cell wall and in several bacteria. The unique characteristics of bacterial cellulose (BC), such as non-toxicity, biodegradability, hydrophilicity, and biocompatibility, together with the modifiable form of nanocellulose, or the integration with nanoparticles, such as nanosilver (AgNP), all for antibacterial effects, contributes to the extensive usage of BC in wound healing applications. Due to this, BC has gained much demand and attention for therapeutical usage over time, especially in the pharmaceutical industry when compared to plant cellulose (PC). This paper reviews the progress of related research based on in vitro, in vivo, and clinical trials, including the overall information concerning BC and PC production and its mechanisms in wound healing. The physicochemical differences between BC and PC have been clearly summarized in a comparison table. Meanwhile, the latest Food and Drug Administration (FDA) approved BC products in the biomedical field are thoroughly discussed with their applications. The paper concludes on the need for further investigations of BC in the future, in an attempt to make BC an essential wound dressing that has the ability to be marketable in the global marketplace.

Matched MeSH terms: Wound Healing*

Fulltext Maggot Therapy in Wound Healing: A Systematic Review

Mohd Zubir MZ, Holloway S, Mohd Noor N

Int J Environ Res Public Health, 2020 08 21;17(17).

PMID: 32825736 DOI: 10.3390/ijerph17176103

BACKGROUND: It is estimated that 2% of the population in developing countries suffer from a chronic wound, making it a hidden phenomenon that is increasing as populations age. The ease of access to maggot therapy has made it increasingly attractive for implementation. This study aimed to explore the effectiveness of maggot therapy as compared to hydrogel dressings in the healing of chronic wounds.

METHODS: An electronic literature search until October 2019 was performed using Medline, Embase, and Cumulative Index of Nursing and Allied Health Literature. The eligibility criteria were chronic wound patients with an intervention that involved a comparison of any maggot species with hydrogel dressings.

RESULTS: The full text of five studies, involving 580 patients with chronic wounds, was retrieved. Four studies used the Lucilia sericata species. The maggot therapy facilitated faster and more effective debridement of non-viable tissue. It enabled faster development of granulation tissue and increased reduction in the wound surface area compared to hydrogel dressings. Maggot therapy had no effect on disinfection or complete healing rate for the wound.

CONCLUSION: Maggot therapy should be considered for faster wound debridement, granulation tissue development, and wound surface area reduction as well as in surgical contraindications. This review can be used as a guide to assist clinicians in identifying patients who may benefit from maggot therapy.

Matched MeSH terms: Wound Healing*

Bond and heal: from Asia with love

Nair HKR

J Wound Care, 2018 Sep 01;27(Sup9a):S3.

PMID: 30207845 DOI: 10.12968/jowc.2018.27.Sup9a.S3

Matched MeSH terms: Wound Healing*

ReGeneraTing Agents (rgta®) technology combined with antibiotics improves outcomes for infections in the upper limb

Roohi SA, Keuylian Z, Barritault D

Clin Case Rep, 2021 Mar;9(3):1083-1091.

PMID: 33768787 DOI: 10.1002/ccr3.3645

A matrix therapy agent marketed as CACIPLIQ20® showed marked improvement in the healing rate of hand infections, including functional recovery. It can be used at both earlier and later stages to promote faster healing and prevent an adverse outcome.

Matched MeSH terms: Wound Healing

Fulltext Honey Dressing in Managing Malignant Fungating Wound: A Case Report

Edith, J., Anantha K. R., Karenita K. S., Surayah M., Filzah M. K., Farhana H., et al.

Borneo Journal of Medical Sciences, 2018;12(101):77-78.

MyJurnal

Honey dressing has been used to treat wounds since thousand years ago, however, it has been vanished of it usage on wounds management. Lately, it resurfaces again and has been used widely by clinicians in managing hard-to-heal ulcers. With the extensive study and research been carried out by scientists, a better understanding on the usage in managing non-healing ulcers has been widely accepted nowadays.

Matched MeSH terms: Wound Healing

Fulltext The new Silk Road

Nair HK

J Wound Care, 2020 Dec 01;29(Sup12):S3.

PMID: 33320766 DOI: 10.12968/jowc.2020.29.Sup12.S3

Matched MeSH terms: Wound Healing*

Fatty acid and amino acid composition in haruan as a potential role in wound healing

Jais AM, McCulloch R, Croft K

Gen. Pharmacol., 1994 Sep;25(5):947-50.

PMID: 7835642

1. Two species of snakehead fish are available in Sabah, i.e. Channa striatus and Channa melanosoma, and are commonly known as haruan. Haruan is consumed by many Malaysians to induce healing after a clinical operations. However, there is no scientific evidence as yet to substantiate the claim, and so it was decided to analyse the biochemical composition in haruan to determine which compounds may have a possible role or potential in wound healing. 2. Samples (midline fillet) of both species were extracted separately in hexane for the qualitative analysis of fatty acids by a gas chromatography, Hewlett-Packard 5890A, using a 10 meter superox 11 column (Alltech) at temperature between 190 and 245 degrees C. Peak areas were calculated automatically using Hewlett-Packard 3393A computing integrator. Subsequently, the amino acid composition was analysed using a precolumn derivatization reverse phase HPLC waters PICO-TAG system. 3. Haruan is found to contain unusually high arachidonic acid (AA) but almost no eicosapentaenoic acid (EPA). AA which is a precursor of prostaglandin may initiate blood clotting and be responsible for growth. Haruan also contains all the essential amino acids for wound healing, particularly glycine which is the most important component of human skin collagen. Therefore, haruan contained all the basic biochemical requirements for wound healing.

Matched MeSH terms: Wound Healing*

Fulltext Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin N, Nordin A, Bt Hj Idrus R, Fauzi MB

Int J Environ Res Public Health, 2020 06 11;17(11).

PMID: 32545210 DOI: 10.3390/ijerph17114160

Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process.

Matched MeSH terms: Wound Healing*

Maggot Debridement Therapy in Malaysia

Nair HKR, Wasi Ahmad N, Teh CH, Lee HL, Chong SSY

Int J Low Extrem Wounds, 2021 Sep;20(3):208-216.

PMID: 32524879 DOI: 10.1177/1534734620932397

Maggot therapy, also known as maggot debridement therapy, larval therapy, biodebridement, or biosurgery, is a type of biotherapy involving the intentional application of live, disinfected fly larvae or maggots into the nonhealing wound of a human or animal to debride the necrotic wound, reduce bacterial contamination of the wound as well as enhance the formation of healthy granulation tissue and stimulate healing in nonhealing wounds. In addition, van der Plas et al reported that the use of the medicinal larvae as natural remover of necrotic and infected tissue had prevented amputation in 11 selected patients. In Malaysia, Aaron et al had demonstrated prevention of amputation in 25 patients.

Matched MeSH terms: Wound Healing*

Fulltext Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective

Zulkefli N, Che Zahari CNM, Sayuti NH, Kamarudin AA, Saad N, Hamezah HS, et al.

Int J Mol Sci, 2023 Feb 27;24(5).

PMID: 36902038 DOI: 10.3390/ijms24054607

Wounds are considered to be a serious problem that affects the healthcare sector in many countries, primarily due to diabetes and obesity. Wounds become worse because of unhealthy lifestyles and habits. Wound healing is a complicated physiological process that is essential for restoring the epithelial barrier after an injury. Numerous studies have reported that flavonoids possess wound-healing properties due to their well-acclaimed anti-inflammatory, angiogenesis, re-epithelialization, and antioxidant effects. They have been shown to be able to act on the wound-healing process via expression of biomarkers respective to the pathways that mainly include Wnt/β-catenin, Hippo, Transforming Growth Factor-beta (TGF-β), Hedgehog, c-Jun N-Terminal Kinase (JNK), NF-E2-related factor 2/antioxidant responsive element (Nrf2/ARE), Nuclear Factor Kappa B (NF-κB), MAPK/ERK, Ras/Raf/MEK/ERK, phosphatidylinositol 3-kinase (PI3K)/Akt, Nitric oxide (NO) pathways, etc. Hence, we have compiled existing evidence on the manipulation of flavonoids towards achieving skin wound healing, together with current limitations and future perspectives in support of these polyphenolic compounds as safe wound-healing agents, in this review.

Matched MeSH terms: Wound Healing/physiology

Fulltext Activity of Plumbago zeylanica Linn. root and Holoptelea integrifolia Roxb. bark pastes in acute and chronic paw inflammation in Wistar rat

Kumar D, Ganguly K, Hegde HV, Patil PA, Roy S, Kholkute SD

J Ayurveda Integr Med, 2014 Jan;5(1):33-7.

PMID: 24812473 DOI: 10.4103/0975-9476.128853

The pastes prepared from roots of Plumbago zeylanica Linn. and barks of Holoptelea integrifolia Roxb. are widely used by traditional healers for the treatment of arthritis in rural northern Karnataka.

Matched MeSH terms: Wound Healing

Irreducible Dorsal Distal Interphalangeal Joint Dislocation of Finger: A Case Report and Perspectives on Management

Sem SH, Omar MF, Muhammad Nawawi RF

Cureus, 2019 May 02;11(5):e4588.

PMID: 31309013 DOI: 10.7759/cureus.4588

Irreducible closed dorsal dislocation of distal interphalangeal (DIP) joint of the finger is a rare injury. The causes of irreducibility of the DIP joint are volar plate interposition, entrapment of flexor digitorum profundus tendon behind the head of middle phalanx, and buttonholing of the middle phalanx head through the volar plate or flexor tendon. Open reduction with a volar approach is recommended with the advantages of better wound healing, ease of releasing entrapped structures, and possibilities of a volar plate, collateral ligaments, and/or flexor tendon repair. We report a case of irreducible dorsal dislocation of left ring finger DIP joint secondary to volar plate interposition treated successfully with open reduction.

Matched MeSH terms: Wound Healing

Fulltext ReGeneraTing Agents (RGTA®): A new option for healing and improving treatment outcomes for traumatic and burn injuries of the hand

Roohi SA, Barritault D

Clin Case Rep, 2019 Apr;7(4):619-625.

PMID: 30997049 DOI: 10.1002/ccr3.2054

CACIPLIQ20® significantly improved the outcomes of severe burn injuries of the hand. Healing was accelerated, with little or no scarring, allowing for greater mobility over the joints and maintained suppleness. Functional recovery was achieved in all cases.

Matched MeSH terms: Wound Healing

Sulphonamide packs in wounds

Yeoh BC

Journal of the Malaya Branch of the British Medical Association, 1941;5:72-6.

Matched MeSH terms: Wound Healing

Fulltext Dielectrophoresis Prototypic Polystyrene Particle Synchronization toward Alive Keratinocyte Cells for Rapid Chronic Wound Healing

Deivasigamani R, Maidin NNM, Wee MFMR, Mohamed MA, Buyong MR

Sensors (Basel), 2021 Apr 25;21(9).

PMID: 33922993 DOI: 10.3390/s21093007

Diabetes patients are at risk of having chronic wounds, which would take months to years to resolve naturally. Chronic wounds can be countered using the electrical stimulation technique (EST) by dielectrophoresis (DEP), which is label-free, highly sensitive, and selective for particle trajectory. In this study, we focus on the validation of polystyrene particles of 3.2 and 4.8 μm to predict the behavior of keratinocytes to estimate their crossover frequency (fXO) using the DEP force (FDEP) for particle manipulation. MyDEP is a piece of java-based stand-alone software used to consider the dielectric particle response to AC electric fields and analyzes the electrical properties of biological cells. The prototypic 3.2 and 4.8 μm polystyrene particles have fXO values from MyDEP of 425.02 and 275.37 kHz, respectively. Fibroblast cells were also subjected to numerical analysis because the interaction of keratinocytes and fibroblast cells is essential for wound healing. Consequently, the predicted fXO from the MyDEP plot for keratinocyte and fibroblast cells are 510.53 and 28.10 MHz, respectively. The finite element method (FEM) is utilized to compute the electric field intensity and particle trajectory based on DEP and drag forces. Moreover, the particle trajectories are quantified in a high and low conductive medium. To justify the simulation, further DEP experiments are carried out by applying a non-uniform electric field to a mixture of different sizes of polystyrene particles and keratinocyte cells, and these results are well agreed. The alive keratinocyte cells exhibit NDEP force in a highly conductive medium from 100 kHz to 25 MHz. 2D/3D motion analysis software (DIPP-MotionV) can also perform image analysis of keratinocyte cells and evaluate the average speed, acceleration, and trajectory position. The resultant NDEP force can align the keratinocyte cells in the wound site upon suitable applied frequency. Thus, MyDEP estimates the Clausius-Mossotti factors (CMF), FEM computes the cell trajectory, and the experimental results of prototypic polystyrene particles are well correlated and provide an optimistic response towards keratinocyte cells for rapid wound healing applications.

Matched MeSH terms: Wound Healing

Polymeric Hydrogel Systems as Emerging Biomaterial Platforms to Enable Hemostasis and Wound Healing

Pourshahrestani S, Zeimaran E, Kadri NA, Mutlu N, Boccaccini AR

Adv Healthc Mater, 2020 10;9(20):e2000905.

PMID: 32940025 DOI: 10.1002/adhm.202000905

Broad interest in developing new hemostatic technologies arises from unmet needs in mitigating uncontrolled hemorrhage in emergency, surgical, and battlefield settings. Although a variety of hemostats, sealants, and adhesives are available, development of ideal hemostatic compositions that offer a range of remarkable properties including capability to effectively and immediately manage bleeding, excellent mechanical properties, biocompatibility, biodegradability, antibacterial effect, and strong tissue adhesion properties, under wet and dynamic conditions, still remains a challenge. Benefiting from tunable mechanical properties, high porosity, biocompatibility, injectability and ease of handling, polymeric hydrogels with outstanding hemostatic properties have been receiving increasing attention over the past several years. In this review, after shedding light on hemostasis and wound healing processes, the most recent progresses in hydrogel systems engineered from natural and synthetic polymers for hemostatic applications are discussed based on a comprehensive literature review. Most studies described used in vivo models with accessible and compressible wounds to assess the hemostatic performance of hydrogels. The challenges that need to be tackled to accelerate the translation of these novel hemostatic hydrogel systems to clinical practice are emphasized and future directions for research in the field are presented.

Matched MeSH terms: Wound Healing

Fulltext Nanotechnology-based therapeutic applications: in vitro and in vivo clinical studies for diabetic wound healing

Haque ST, Saha SK, Haque ME, Biswas N

Biomater Sci, 2021 Nov 23;9(23):7705-7747.

PMID: 34709244 DOI: 10.1039/d1bm01211h

Diabetic wounds often indicate chronic complications that are difficult to treat. Unfortunately, existing conventional treatment modalities often cause unpremeditated side effects, given the need to develop alternative therapeutic phenotypes that are safe or have minimal side effects and risks. Nanotechnology-based platforms, including nanotherapeutics, nanoparticles (NPs), nanofibers, nanohydrogels, and nanoscaffolds, have garnered attention for their groundbreaking potential to decipher the biological environment and offer personalized treatment methods for wound healing. These nanotechnology-based platforms can successfully overcome the impediments posed by drug toxicity, existing treatment modalities, and the physiology and complexity of the wound sites. Furthermore, studies have shown that they play an essential role in influencing angiogenesis, collagen production, and extracellular matrix (ECM) synthesis, which are integral in skin repair mechanisms. In this review, we emphasized the importance of various nanotechnology-based platforms for healing diabetic wounds and report on the innovative preclinical and clinical outcomes of different nanotechnology-based platforms. This review also outlined the limitations of existing conventional treatment modalities and summarized the physiology of acute and chronic diabetic wounds.

Matched MeSH terms: Wound Healing

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