MyMedR

Fulltext Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

Lin C, Chen Z, Zhang L, Wei Z, Cheng KK, Liu Y, et al.

Parasit Vectors, 2019 Jun 13;12(1):300.

PMID: 31196218 DOI: 10.1186/s13071-019-3554-0

BACKGROUND: Hepatic alveolar echinococcosis (HAE) is caused by the growth of Echinococcus multilocularis larvae in the liver. It is a chronic and potentially lethal parasitic disease. Early stage diagnosis for this disease is currently not available due to its long asymptomatic incubation period. In this study, a proton nuclear magnetic resonance (1H NMR)-based metabolomics approach was applied in conjunction with multivariate statistical analysis to investigate the altered metabolic profiles in blood serum and urine samples obtained from HAE patients. The aim of the study was to identify the metabolic signatures associated with HAE.

RESULTS: A total of 21 distinct metabolic differences between HAE patients and healthy individuals were identified, and they are associated with perturbations in amino acid metabolism, energy metabolism, glyoxylate and dicarboxylate metabolism. Furthermore, the present results showed that the Fischer ratio, which is the molar ratio of branched-chain amino acids to aromatic amino acids, was significantly lower (P

Matched MeSH terms: Echinococcosis, Hepatic/blood; Echinococcosis, Hepatic/metabolism*; Echinococcosis, Hepatic/urine

Preliminary assessment of the diagnostic performances of a new rapid diagnostic test for the serodiagnosis of human cystic echinococcosis

Vola A, Tamarozzi F, Noordin R, Yunus MH, Khanbabaie S, De Silvestri A, et al.

Diagn Microbiol Infect Dis, 2018 Sep;92(1):31-33.

PMID: 29776711 DOI: 10.1016/j.diagmicrobio.2018.04.007

Rapid diagnostic tests for cystic echinococcosis (CE) are convenient to support ultrasound diagnosis in uncertain cases, especially in resource-limited settings. We found comparable diagnostic performances of the experimental Hyd Rapid Test and the commercial VIRapid HYDATIDOSIS Test, used in our diagnostic laboratory, using samples from well-characterized hepatic CE cases.

Matched MeSH terms: Echinococcosis, Hepatic/diagnosis*; Echinococcosis, Hepatic/parasitology

Fulltext Hepatic hydatidosis: diagnostic and therapeutic aspects

Jalleh RP, Nuruddin R, Krishnan MMS

Singapore Med J, 1989 Apr;30(2):210-2.

PMID: 2692183

A rare case of hepatic hydatidosis in non-endemic Malaysia is reported. It is important that clinicians treating the occasional patient be familiar with current diagnostic and therapeutic modalities.

Matched MeSH terms: Echinococcosis, Hepatic/diagnosis*; Echinococcosis, Hepatic/surgery

[Primary liver carcinoma. Review]

Korenek J

Vnitr Lek, 1970 Apr;16(4):371-8.

PMID: 4910163

Matched MeSH terms: Echinococcosis, Hepatic/diagnosis

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