MyMedR

A study of the etiology of gynaecological disease in a group of nuns

Boyd ME

Med J Malaya, 1969 Dec;24(2):121-3.

Matched MeSH terms: Genital Diseases, Female/etiology*

Fulltext Abstracts of the RCOG (Royal College of Obstetricians and Gynaecologists) 10th International Scientific Congress. June 5-8, 2012. Kuching, Sarawak, Malaysia

BJOG, 2012 Jun;119 Suppl 1:2-250.

PMID: 22672235 DOI: 10.1111/j.1471-0528.2012.03375.x

Matched MeSH terms: Genital Diseases, Female*

The Karman curette for gynaecological diagnostic curettage. (A preliminary report)

Chelvam P, Puraviappan, Sinnathuray TA

Med J Malaysia, 1978 Dec;33(2):158-61.

PMID: 755170

Matched MeSH terms: Genital Diseases, Female/pathology*

Fulltext Upper genital schistosomiasis mimicking an ovarian tumour

Shekhar KC, Soh EBS, Jayalakshmi P

Med J Malaysia, 2000 Sep;55(3):371-5.

PMID: 11200720

Schistosomiasis is a widely prevalent disease in the world and usually involves the gastro-intestinal and urinary tract. The involvement of the female genital tract has been well-established in S. haematobium infections and is rare with S. japonicum infections. This case involves a Filipino female who was admitted to the University Hospital Kuala Lumpur for right iliac fossa pain and was diagnosed initially as acute appendicitis. Ultrasound showed a multi-septated pelvic cyst leading to a provisional diagnosis of ovarian torsion. Intraoperatively a right parovarian cyst was detected and removed. Histology revealed a congested cyst wall with areas of haemorrhage with several viable and calcified eggs of S. japonicum measuring 85 microns x 62 microns. Within the cystic cavity blood admixed with eggs were seen. Confirmation was carried out by using the indirect haemagglutination (IHA) test. This is a first report of upper genital schistosomiasis mimicking an ovarian tumour.

Matched MeSH terms: Genital Diseases, Female/diagnosis*; Genital Diseases, Female/parasitology; Genital Diseases, Female/pathology

Urogenital myiasis caused by Chrysomya bezziana (Diptera: Calliphoridae) in peninsular Malaysia

Ramalingam S, Nurulhuda A, Bee LH

Southeast Asian J. Trop. Med. Public Health, 1980 Sep;11(3):405-7.

PMID: 7444582

A case of urogenital myiasis caused by Chrysomya bezziana (Diptera: Calliphoridae) was diagnosed in a 76-year old patient who had carcinoma of the rectum. A total of 35 larvae were obtained from ulcers near the external genitalia and urethra opening. Larvae pupated within 1 to 2 days and 6 days later emerged as adult males. These were identified as Chrysomya bezziana. Female flies possibly attracted by the fetid odour, laid eggs in the existing lesions in the urogenital area, the larvae invading and feeding on living tissue. Lack of personal hygiene was the contributing factor for the cause of urogenital myiasis in this patient.

Matched MeSH terms: Genital Diseases, Female/parasitology*

Development and validation of the genitourinary syndrome of menopause symptoms and vaginal treatments acceptability questionnaire (GSM-SVTAQ): An electronic patient-reported outcomes measure

Hassanein MM, Huri HZ, Baig K, Abduelkarem AR, Al-Momani M

Int J Gynaecol Obstet, 2024 Feb;164(2):613-623.

PMID: 37702968 DOI: 10.1002/ijgo.15106

OBJECTIVES: To develop and validate an electronic, patient-reported outcomes measure (PROM) specific for genitourinary syndrome of menopause (GSM) patients. The PROM aimed to accurately assess the burden of GSM symptoms, their impact on health-related and sexual quality of life, and the acceptability of vaginal treatments.

METHODS: The study encompassed a comprehensive three-stage approach to the development and validation of the PROM. Initially, during the preliminary design stage, the necessity for a new PROM was recognized, an expert panel was formed, and semi-structured qualitative interviews were carried out with GSM patients. In the second stage, the study used the five-step pre-validation methodology established by Prior et al. to generate and refine the PROM items. The third and final stage encompassed the determination of scale and item content validity indexes to ensure validity. Additionally, the reliability of each construct was evaluated using Cronbach's α.

RESULTS: The resulting PROM was named GSM-SVTAQ (GSM-symptoms and vaginal treatments acceptability questionnaire). It demonstrated excellent validity in assessing symptoms burden, health-related and sexual quality of life, and vaginal treatment acceptability, with high content validity indices and strong internal consistency. The scale content validity indices and Cronbach's α coefficients for the three domains were (0.926, 0.939), (0.875, 0.947), and (0.824, 0.855), respectively.

CONCLUSION: The GSM-SVTAQ stands as the first GSM-specific, valid, and reliable PROM capable of comprehensively measuring the three components of GSM and the acceptability of vaginal treatments. Its implementation has the potential to significantly enhance patient care and outcomes in GSM management.

Matched MeSH terms: Genital Diseases, Female*

An unusual case to pentastomiasis of the fallopian tube in an Aborigine woman

Ong HC

J Trop Med Hyg, 1974 Aug;77(8):187-9.

PMID: 4422640

Matched MeSH terms: Genital Diseases, Female/parasitology; Genital Diseases, Female/pathology

Fulltext Rapid detection of Haemophilus ducreyi in clinical and experimental infections using monoclonal antibody: a preliminary evaluation

Karim QN, Finn GY, Easmon CS, Dangor Y, Dance DA, Ngeow YF, et al.

Genitourin Med, 1989 Dec;65(6):361-5.

PMID: 2693334

A monoclonal antibody raised against Haemophilus ducreyi was tested for its sensitivity and specificity as an immunofluorescence (IF) reagent using simulated vaginal smears containing H. ducreyi, smears taken from skin lesions of mice infected with H. ducreyi and patients from South Africa, Thailand and Malaysia with clinically diagnosed chancroid. The IF test was more sensitive than culture or Gram staining in the simulated smears, theoretically detecting less than 4 organisms/sample. It detected H. ducreyi in 95% of the animal lesions compared with 14% detected by culture. Immunofluorescence testing identified over 90% of culture-positive cases of chancroid but also detected organisms in some culture-negative cases where clinical evidence for the diagnosis was strong. These results suggest that this antibody may provide a simple, rapid and sensitive means of detecting H. ducreyi in cases of chancroid.

Matched MeSH terms: Genital Diseases, Female/diagnosis*; Genital Diseases, Female/immunology

Fulltext Gartner duct cyst in pregnancy presenting as a prolapsing pelvic mass

Arumugam A, Kumar G, Si L, Vijayananthan A

Biomed Imaging Interv J, 2007 Oct;3(4):e46.

PMID: 21614298 MyJurnal DOI: 10.2349/biij.3.4.e46

Gartner duct cysts are the remnants of the Wolffian duct and they are rarely seen in adulthood. We present a case of a pregnant patient with a prolapsing vaginal mass. A diagnosis of Gartner duct cyst was made after MRI was performed. The Gartner duct cyst was drained when the patient went into labour allowing vaginal delivery to be performed.

Matched MeSH terms: Genital Diseases, Female

Fulltext Ureteral injuries in an obstetric and gynaecology teaching hospital

Yeong CT, Lim TLW, Tan KH

Med J Malaysia, 1998 Mar;53(1):51-8.

PMID: 10968138

Between November 1994 to May 1996, there was a total of eight ureteric injuries out of 2495 major gynaecologic operations and one ureteric injury out of 4146 caesarean sections at the Kandang Kerbau Hospital, giving the incidence to be 0.3% and 0.02% respectively. Antecedent operations were four abdominal hysterectomies, two Werthiem's hysterectomies, one laparoscopic-assisted vaginal hysterectomy and one caesarean section. All operations were performed by qualified specialists. Three patients had previous abdominal operations and five patients had procedures complicated by dense adhesions. Only one injury was detected intraoperatively and the rest presented with uretero-vaginal fistula. One presented with immediate postoperative anuria. The average time interval for diagnosis ranged between one day and twenty-three days (average 10.7 days). The commonest damage was transection of the ureter. Double J stents were used in all repairs with two cases requiring reimplantation with psoas hitch, and two cases of ureteroneocystostomies and one case of primary reanastomosis. There were no mortality in our series.

Matched MeSH terms: Genital Diseases, Female/surgery*

Fulltext Delayed recovery following lorazepam premedication

Inbasegaran K, Aun LT

Med J Malaysia, 1990 Sep;45(3):251-3.

PMID: 2152088

Oral lorazepam is a commonly used premedicant both locally and abroad. We studied its effect on recovery time after minor gynaecological procedures. The results showed a significant prolongation of recovery time.

Matched MeSH terms: Genital Diseases, Female/surgery

Genital human papillomavirus infection among women from major ethnic groups in Singapore

Chow VT, Tham KM, Lim-Tan SK, Sng IT, Bernard HU

Asia Oceania J Obstet Gynaecol, 1990 Dec;16(4):373-7.

PMID: 1966000

The close epidemiological relationships between specific genital human papillomavirus (HPV) types and neoplasia of the cervix uteri have been extensively documented worldwide, including Singapore. Cervical cancer incidence rates in Singapore show variations between the major ethnic groups. To ascertain the corresponding HPV infection rates among the various races in Singapore, we analysed the cervical smears of 225 women by filter in situ DNA hybridization, and compared the data with a previous similar study. Fourteen (6.2%) individuals were HPV-positive, with HPV 16 and HPV 31 being the commonest types. No significant difference between HPV positivity rates in Chinese (5.0%) and in Malays (6.7%) was found, even though Chinese have a higher cervical cancer incidence than Malays. Furthermore, the cervical HPV carriage rate among women with normal cytology was 5.9%. In the light of reports of high genital HPV prevalence rates detected by DNA amplification, these data support the notion that HPV infection is commonly latent and requires the cooperation of other factors for cervical carcinogenesis.

Matched MeSH terms: Genital Diseases, Female/ethnology*

Genital infections with chlamydia trachomatis

Ngeow YF, Ong SB, Thong ML, Teoh SK, Omar R, Low BT

Med J Malaysia, 1979 Sep;34(1):65-70.

PMID: 542157

Matched MeSH terms: Genital Diseases, Female/diagnosis*

Fulltext A microbiological study of genital ulcers in Kuala Lumpur

Zainah S, Cheong YM, Sinniah M, Gan AT, Akbal K

Med J Malaysia, 1991 Sep;46(3):274-82.

PMID: 1839925

The microbial aetiology of genital ulcers was studied in 249 patients (241 men and 8 women) attending a Sexually Transmitted Disease Clinic in Kuala Lumpur, Malaysia. Herpes simplex virus type 2 was isolated in 48 (19.2%) patients, Haemophilus ducreyi from 22 (8.8%), Neisseria gonorrhoeae from seven (2.8%) and Chlamydia trachomatis from four (1.6%). Syphilis was diagnosed in 18 (7.2%) patients on the basis of dark field microscopy. Two (0.8%) patients were found to have both chancroid and syphilis and one (0.5%) had both gonorrhoea and syphilis. No organism was isolated in the remaining 151 (61.5%) patients. Overall, the accuracy of clinical diagnosis was 58% for single infection, 67% for herpes, 63% for syphilis, 47% for chancroid and 0% for lymphogranuloma venereum. Therefore, our study confirms the need for laboratory tests to diagnose accurately the aetiology of genital ulcer disease.

Matched MeSH terms: Genital Diseases, Female/microbiology*

Enterobiasis: a histopathological study of 259 patients

Sinniah B, Leopairut J, Neafie RC, Connor DH, Voge M

Ann Trop Med Parasitol, 1991 Dec;85(6):625-35.

PMID: 1811440

Enterobius worms or their eggs, or both, are present in preserved tissue sections or tissue specimens of 259 patients whose medical records are on file at the Armed Forces Institute of Pathology, Washington D.C., U.S.A. The most common site of infection (86.5%) was found to be the lumen of the appendix, where the worms provoke no reaction. Of the 259 patients 11 (4.2%) had worms and/or eggs in granulomas of the abdominal and pelvic peritoneum, and an equal number had granulomas on the peritoneum of the salphinx or on the surface of the ovary. There were also ectopic worms and/or eggs in granulomas on the peritoneum of the small and large intestines (2.7%). These Enterobius granulomas form around degenerating adult worms, around discrete eggs, around clusters of eggs, and, we believe, also around the tracks of migrating worms. Three patients (1.2%) had worms in perianal abscesses. A necrotic granuloma, removed from the lung of one patient, surrounded a degenerating adult worm. This suggests that the worm, carried to the lung as an embolus, impacted in a pulmonary arteriole. A stool specimen of one patient contains eggs of Enterobius, and that of another patient contains an adult Enterobius. This is the largest recorded histopathological study of enterobiasis in man.

Matched MeSH terms: Genital Diseases, Female/pathology*

A comparison of trimethoprim-sulphamethoxazole and penicillin-streptomycin in the treatment of gynaecological infections

Wong WP, Ng KH, Chai KH

Med J Malaysia, 1973 Dec;28(2):125-7.

PMID: 4276230

Matched MeSH terms: Genital Diseases, Female/drug therapy*

New Zealand Malayan war veterans' exposure to dibutylphthalate is associated with an increased incidence of cryptorchidism, hypospadias and breast cancer in their children

Carran M, Shaw IC

N Z Med J, 2012;125(1358):52-63.

PMID: 22864157

It is well known that the endocrine-disrupting chemical (EDC) dibutylphthalate (DBP) inhibits testosterone synthesis and can lead to feminisation in male laboratory animals. Moreover, it has long been speculated that human exposure would result in the similar effects, but this is difficult to study because specific human exposure cohorts are rare. We report increases in the incidences of hypospadias (p<0.05), cryptorchidism (p<0.05) and breast cancer (p<0.05) in the children of New Zealand soldiers who served in Malaya (1948-1960) and were exposed to DBP applied daily to their clothing as an acaricide to prevent tick-transmitted bush typhus. In addition, we modelled absorption of DBP from the soldiers' clothing and using published data for skin absorption, and calculated a large theoretical absorbed dose of 64 mg/kg body weight/day which is similar to DBP's lowest observed adverse effect level (LOAEL) of 50 mg/kg body weight/day and thus indicates a biological effect is possible. This is the first report of a multigenerational developmental effect following DBP exposure in human males.

Matched MeSH terms: Genital Diseases, Female/etiology; Genital Diseases, Female/epidemiology

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