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Immature platelet fraction as a useful marker in Crimean-Congo hemorrhagic fever

Ozmen ZC, Deveci K, Coskun USS, Ozmen Z, Aydogan L, Barut HS

Trop Biomed, 2023 Mar 01;40(1):101-107.
PMID: 37356009 DOI: 10.47665/tb.40.1.016

The aim of this study is to evaluate the clinical significance and diagnostic performance of the immature platelet fraction (%IPF) in Crimean-Congo hemorrhagic fever (CCHF). Samples obtained from 32 healthy control subjects and 40 CCHF patients (9 positive and 31 negative radiological findings) were evaluated in the study. The samples obtained from CT-positive subjects demonstrated higher IPF% values which also exhibited a positive correlation with mean platelet volume (MPV) and platelet size deviation width (PDW) values.The patient group IPF% values were positively correlated with the duration of hospital stay. The ROC analysis also suggested the potential importance of IPF values higher than 10.5% in diagnosing CCHF patients with positive radiological findings.The results of our study showed that % IPF can be considered as a useful parameter in the follow-up of the disease course in patients with CCHF.

Matched MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo*
Fulltext Potential of Crimean-Congo Hemorrhagic Fever outbreak during Eid-Ul-Adha Islamic festival and COVID-19 pandemic in Pakistan

Ahmed A, Tahir MJ, Siddiqi AR, Dujaili J

J Med Virol, 2021 01;93(1):182-183.
PMID: 32644233 DOI: 10.1002/jmv.26285
Matched MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo/pathogenicity
Fulltext Knowledge, attitudes, and practices regarding Crimean-Congo hemorrhagic fever among general people: A cross-sectional study in Pakistan

Jamil H, Din MFU, Tahir MJ, Saqlain M, Hassan Z, Khan MA, et al.

PLoS Negl Trop Dis, 2022 Dec;16(12):e0010988.
PMID: 36480553 DOI: 10.1371/journal.pntd.0010988

BACKGROUND: Crimean-Congo hemorrhagic fever (CCHF) continues to pose a serious threat to the fragile healthcare system of Pakistan with a continuous increase of morbidity and mortality. The present study aimed to assess the knowledge, attitudes, and practices regarding CCHF among general people who resided in Pakistan.
METHODS: An online cross-sectional survey design was applied, and a convenience sampling technique was used to recruit 1039 adult people from Pakistan. Data were collected from September 08 to October 12, 2021. The questionnaire consisted of a total of 32 questions in four parts assessing socio-demographics, as well as knowledge, attitudes, and practices regarding CCHF. All statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS), and logistic regression analyses were performed to determine the factors associated with good knowledge, positive attitudes, and good practices.
RESULTS: Alarmingly, 51.5% of participants heard about CCHF infection before administering the survey. Among these, 20.2%, 33.3%, and 48.2% of the study participants had demonstrated good knowledge, positive attitudes, and good practices, respectively. Binary logistic regression analysis revealed that education and income status had a significant impact on knowledge and attitudes (p<0.05). Similarly, the mean attitude scores differed significantly by age, education, and income status (p<0.05).
CONCLUSIONS: The findings reflected inadequate levels of knowledge, attitudes, and practices regarding CCHF among general people in Pakistan which may regard as lower than expected. As CCHF is a highly contagious disease, it's urgent to initiate a comprehensive approach to handle the situation before it spreads further in Pakistan.

Matched MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo*
Reduced phosphorylated Foxp3 levels in Crimean Congo haemorrhagic fever

Gazi U, Baykam N, Karasartova D, Tosun O, Akdogan O, Yapar D, et al.

Trop Biomed, 2022 Dec 01;39(4):587-591.
PMID: 36602220 DOI: 10.47665/tb.39.4.016

Crimean-Congo haemorrhagic fever (CCHF) is a severe human infection which can lead to fatal consequences. Acute CCHF patients were previously shown to exhibit frequencies of regulatory T-cell (Treg) but lower Treg-mediated suppressive activities than the healthy counterparts. This study aims is to investigate the phosphorylation levels of Foxp3 protein (master regulator of Treg cells) in CCHF patients. Blood samples collected from 18 CCHF patients and nine healthy volunteers were used to isolate peripheral blood mononuclear cells (PBMCs). Total and phosphorylated Foxp3 expression levels in the isolated PBMC samples were monitored by western blot and quantified using ImageJ software. Total Foxp3 expression levels in CCHF patients displayed decreasing trend, but not significantly. In contrast, significantly lower expression levels of phosphorylated Foxp3 were reported in CCHF patients. Our results suggest a possible association between Foxp3 dephosphorylation and CCHF pathogenesis. Nevertheless, more studies are required to evaluate the effect of Foxp3 dephosphorylation on Treg function, which would not only help to enlighten the CCHF pathogenesis but also contribute to the development of effective treatment strategies.

Matched MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo*
Crimean-Congo haemorrhagic fever virus and Eid-Ul-Adha festival in Pakistan

Mallhi TH, Khan YH, Sarriff A, Khan AH

Lancet Infect Dis, 2016 12;16(12):1332-1333.
PMID: 27998596 DOI: 10.1016/S1473-3099(16)30453-4
Matched MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo*
First report on the seroprevalence of the Crimean-Congo haemorrhagic fever virus, a tick-borne virus, in Malaysia's Orang Asli population

Lani R, Mohd Rahim NF, Hassan H, Yaghoobi R, Chang LY, AbuBakar S, et al.

Eur Rev Med Pharmacol Sci, 2015;19(3):461-6.
PMID: 25720719

The Crimean-Congo haemorrhagic fever virus (CCHFV), which is transmitted by the ticks of Hyalomma spp. in general and H. marginatumin particular, can cause severe disease in humans, with mortality rates of 3-30%. Other than from the bites of infected ticks, CCHFV can also be transmitted through contact with patients with the acute phase of infection or contact with blood or tissues from viraemic livestock. Outbreaks of human cases of haemorrhagic manifestations have been documented since 1945 and described in parts of Africa, Asia, Eastern Europe and the Middle East and most recently India in 2011. In addition, serological evidence of the disease has been reported in some countries where no human cases were reported. As regional neighbours China and India have been affected by this virus, this study was conducted to determine the seroprevalence of CCHFV among Orang Asli population of Malaysia as the most at risk people who residing in the deep forests.

Matched MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo/metabolism*
Fulltext Seroprevalence report on tick-borne encephalitis virus and Crimean-Congo hemorrhagic fever virus among Malaysian's farm workers

Mohd Shukri M, Ling Kho K, Ghane Kisomi M, Lani R, Marlina S, Muhd Radzi SF, et al.

BMC Public Health, 2015;15:704.
PMID: 26205588 DOI: 10.1186/s12889-015-1901-4

Tick-borne encephalitis virus (TBEV) and Crimean-Congo haemorrhagic fever virus (CCHFV) are important tick-borne viruses. Despite their wide geographical distribution and ease of acquisition, the prevalence of both viruses in Malaysia is still unknown. This study was conducted to determine the seroprevalence for TBEV and CCHFV among Malaysian farm workers as a high-risk group within the population.

Matched MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo/immunology*