MyMedR

Fulltext Two cases of human sarcocystosis in East Malaysia

Pathmanathan R, Kan SP

Med J Malaysia, 1987 Sep;42(3):212-4.

The first two cases of human muscular sarcocystosis are reported from East Malaysia, in Sabalt and Sarawak respectively. Sarcocysts were seen iin biopsied specimen from the nasopharynx of both patients who had carcinoma of the nasopharynx. The measurements and appearances of the cysts and the zoites within the cysts were compared with the human cases of sarcocystosis previously reported in West Malaysia. Zoonotic and other aspects of these cases of East Malaysian sarcocystosis are discussed.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Nasopharyngeal chordoma

Sakkarapani V, Panicker C

Med J Malaysia, 1977 Mar;31(3):208-12.

PMID: 904513

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology

Fulltext A rare case of nasopharyngeal carcinosarcoma

Lim AL, Zahirrudin Z, Pua KC

Med J Malaysia, 2012 Aug;67(4):428-9.

PMID: 23082458 MyJurnal

Nasopharnygeal carcinoma is known to be the commonest tumour of the nasopharynx. However, the incidence of nasopharngeal carcinosarcoma is extremely rare. Carcinosarcoma has been reported to be aggressive in nature and therefore early diagnosis and prompt treatment is important. We report a young lady who was diagnosed with nasopharyngeal carcinosarcoma in our centre. She presented with only 2 weeks history of nose block and was noted to have a mass occupying the nasopharynx with neck metastasis. She underwent panendoscope and biopsy with radical radiotherapy.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Fulltext Sinonasal malignant melanocytic melanoma: a rare case report

Pathma L, Philip R, Harvinder S, Manjit S

Med J Malaysia, 2008 Jun;63(2):152-3.

PMID: 18942306 MyJurnal

Malignant melanocytic melanoma is a rare sinonasal malignancy. We present a case report of an elderly lady who presented with epistaxis and intranasal polyps. Computed tomography revealed soft tissue mass in the oropharynx, nasopharynx, left ethmoid and entire maxillary sinus. The mass was removed via endoscopic medial maxillectomy. Histopathology examination revealed sinonasal melanocytic malignant melanoma. At present 17 months postoperatively she is symptom free with no recurrence and under regular follow up.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Unusual presentation of chorion epithelioma malignum

Subramanyam C, Lal M

Med J Malaya, 1970 Jun;24(4):306-7.

PMID: 4248354

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Nasopharyngeal carcinoma with spinal secondaries

Elango S, Kareem BA, Chandrasekaran S, Azman N

J Laryngol Otol, 1991 Sep;105(9):772-3.

PMID: 1919352 DOI: 10.1017/s0022215100117281

Nasopharyngeal carcinoma has been reported to have a higher incidence of distant metastases as compared to other head and neck cancers. Distant metastases of nasopharyngeal carcinoma has been reported in the bones, lungs, liver, distant lymph nodes, brain and porta hepatis. This report presents a case of nasopharyngeal carcinoma with secondaries in the extradural space at the thoracic level of the spinal cord which hitherto has been an unreported site.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Fulltext Lymphoepitheliomas of the cervical lymph nodes

Loke YW

Br. J. Cancer, 1965 Sep;19(3):482-5.

PMID: 5833066 DOI: 10.1038/bjc.1965.56

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Study of epithelial migration in the tympanic membrane and bony external auditory canal wall in patients with irradiated nasopharyngeal carcinoma

Santhi K, Prepageran N, Tang IP, Raman R

Otol Neurotol, 2015 Feb;36(2):318-22.

PMID: 24751743 DOI: 10.1097/MAO.0000000000000378

The objectives of this study were to determine the presence of epithelial migration in patients with postirradiated nasopharyngeal carcinoma (NPC) and to compare the rate of epithelial migration in the tympanic membrane (TM) and the bony external auditory canal (EAC) of postirradiated NPC ears with normal ears by means of the ink dot method.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Recurrence of a nasopharyngeal carcinoma manifesting as a cerebellopontine angle mass

Kong MH, Jeevanan J, Jegan T

Ear Nose Throat J, 2013 Dec;92(12):E11-3.

PMID: 24366707

As many as 31% of patients with nasopharyngeal carcinoma present with intracranial extension. Despite this high percentage, extension to the cerebellopontine angle is rare. The mechanism of tumor spread to the cerebellopontine angle is not completely understood. The most likely mechanism is direct extension to the skull base with involvement of the petrous apex and further extension posteriorly via the medial tentorial edge. We report the case of a 46-year-old woman with nasopharyngeal carcinoma who had been treated initially with chemoradiation and subsequently with stereotactic radiosurgery for residual tumor. One year later, she presented with an intracranial recurrence of the nasopharyngeal carcinoma in the cerebellopontine angle; the recurrence mimicked a benign tumor on magnetic resonance imaging. The tumor was ultimately diagnosed as an undifferentiated carcinoma of nasopharyngeal origin. She was treated with palliative chemotherapy.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Nasolacrimal relapse of nasopharyngeal carcinoma

Sia KJ, Tang IP, Kong CK, Tan TY

J Laryngol Otol, 2012 Aug;126(8):847-50.

PMID: 22804860 DOI: 10.1017/S0022215112001272

To describe three rare cases of nasolacrimal relapse of nasopharyngeal carcinoma, and to discuss the route of tumour spread from nasopharynx to lacrimal system as well as the relevant computed tomography findings.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Fulltext Lack of Rb2/p130 genetic alteration in Malaysian nasopharyngeal carcinoma

Hoe SL, Lee ES, Khoo AS, Peh SC

Malays J Pathol, 2009 Jun;31(1):53-6.

PMID: 19694314 MyJurnal

The retinoblastoma-related gene Rb2/p130 has been reported to be mutated in several malignancies such as lung cancer and Burkitt's lymphoma. Nasopharyngeal carcinoma (NPC) is a common cancer in Malaysia especially amongst the ethnic Chinese. We screened for Rb2/p130 gene (exons 19 to 21) mutations in 53 archival NPC samples via PCR-SSCP-direct sequencing approach. Only one sample had a base change which involved a serine to glycine substitution at codon 995 (S995G). We conclude that Rb2/p130 genetic alterations are infrequent in NPC and may not be essential for the pathogenesis of the disease.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology

Fulltext Clinical presentation of nasopharyngeal carcinoma in Sarawak Malaysia

Tiong TS, Selva KS

Med J Malaysia, 2005 Dec;60(5):624-8.

PMID: 16515114

Nasopharyngeal carcinoma (NPC) is a common cancer in Malaysia. The clinical presentation in Sarawak has not been well documented. A retrospective review of 213 selected NPC cases was undertaken on the clinical records in Sarawak General Hospital, Sarawak, from June 1999 to June 2003. There were 116 patients in Kuching and 97 in Serian. There were twice as many males as females. The youngest patient was 16 and the oldest 88 years old with a mean age of 51 years. The four most common symptoms in order of frequencies were cervical lymphadenopathy, epistaxis, hearing loss and diplopia. 80.8% of the patients presented with cervical lymphadenopathy and about 85% of the patients presented in the advanced stages. Very small percentages of the patients were found to have single presenting symptoms of epistaxis (2.4%) and hearing loss (0.5%).

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology

Fulltext Papillary adenocarcinoma of the nasopharynx--case report and review of the literature

Nojeg MM, Jalaludin MA, Jayalakshmi P

Med J Malaysia, 1998 Mar;53(1):104-6.

PMID: 10968147

We report a rare tumour of the nasopharynx- papillary adenocarcinoma. This is usually of low grade and certainly in out patient it behaved so. It is even rarer to have this tumour in a patient with Turner's syndrome in whom there is a high incidence of gynaecological malignancy. It has not previously been documented and the occurrence in this patient is probably coincidental.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology

Nasopharyngeal carcinoma in Malaysians under the age of 20 years

Yadav M, Tan MK, Singh P, Dharmalingam SK

Clin Oncol, 1984 Dec;10(4):353-61.

PMID: 6509817

A total of 52 cases of NPC were found in a five-year survey from 1978 to 1982 in Malaysia. The annual rate of occurrence was 3.4, 3.0, 2.4 and 1.8 for Chinese, Malays, Kadazans and Sarawakians, respectively. The age-specific incidence rates per 100 000 were highest for Kadazans (2.34 to 7.59) in comparison to the other races (0.11 to 1.24). The proportion of NPC in young Malaysians formed 1.2% in Chinese, 7.2% in Malays and 6.9% for others. A sexual bias was present in Chinese (male:female = 2.2) and Sarawakians (1.7) but not in Kadazans and Malays (0.9). In most Chinese, the primary tumour histologically is of the poorly differentiated characteristic and this type is the predominant tumour in the country. The Kadazans presented with well differentiated primary tumour and the Malays with all three histological types i.e. well-, poorly- and undifferentiated. At first examination enlarged lymph nodes were found in 95.7% of the patients and 65.2% had epistaxis and growth in the postnasal space. Antibodies to IgA anti-VCA were present in half of the 6 patients serologically studied.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology

Optic nerve involvement in nasopharyngeal carcinoma

Prasad U, Doraisamy S

Eur J Surg Oncol, 1991 Oct;17(5):536-40.

PMID: 1936303

Five rare cases of nasopharyngeal carcinoma with optic nerve involvement are reported. Computerised Tomographic Scan (CT Scan) studies were performed in four of them. Evidence of intracranial spread of the tumour, from the roof of the fossa of Rosenmuller to the apex of the orbit through the cavernous sinus, was noted in three patients. In one of them there was extracranial extension of the tumour, to the orbit through the posterior ethmoid.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Fulltext Clinical presentation of patients with nasopharyngeal carcinoma

Suzina SAH, Hamzah M

Med J Malaysia, 2003 Oct;58(4):539-45.

PMID: 15190630

The poor prognosis for patients with nasopharyngeal carcinoma is principally due to its advanced stage at the time of diagnosis. The symptoms and clinical findings at presentation of 56 patients with confirmed nasopharyngeal carcinoma is described and analysed. Recognising the common modes of presentation is essential to diagnose the disease at an early stage.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Fulltext Shock Index: A Simple and Effective Clinical Adjunct in Predicting 60-Day Mortality in Advanced Cancer Patients at the Emergency Department

Cheng TH, Sie YD, Hsu KH, Goh ZNL, Chien CY, Chen HY, et al.

Int J Environ Res Public Health, 2020 07 07;17(13).

PMID: 32646021 DOI: 10.3390/ijerph17134904

Deciding between palliative and overly aggressive therapies for advanced cancer patients who present to the emergency department (ED) with acute issues requires a prediction of their short-term survival. Various scoring systems have previously been studied in hospices or intensive care units, though they are unsuitable for use in the ED. We aim to examine the use of a shock index (SI) in predicting the 60-day survival of advanced cancer patients presenting to the ED. Identified high-risk patients and their families can then be counseled accordingly. Three hundred and five advanced cancer patients who presented to the EDs of three tertiary hospitals were recruited, and their data retrospectively analyzed. Relevant data regarding medical history and clinical presentation were extracted, and respective shock indices calculated. Multivariate logistic regression analyses were performed. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive performance of the SI. Nonsurvivors within 60 days had significantly lower body temperatures and blood pressure, as well as higher pulse rates, respiratory rates, and SI. Each 0.1 SI increment had an odds ratio of 1.39 with respect to 60-day mortality. The area under the ROC curve was 0.7511. At the optimal cut-off point of 0.94, the SI had 81.38% sensitivity and 73.11% accuracy. This makes the SI an ideal evaluation tool for rapidly predicting the 60-day mortality risk of advanced cancer patients presenting to the ED. Identified patients can be counseled accordingly, and they can be assisted in making informed decisions on the appropriate treatment goals reflective of their prognoses.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Fulltext Retrospective Analysis of Cancer Care Performance and Survival Outcome for Nasopharyngeal Carcinoma at a leading Cancer Treatment Centre in Malaysia 2008-2012

Abdullah MM, Foo YC, Yap BK, Lee CML, Hoo LP, Lim TO

Asian Pac J Cancer Prev, 2019 06 01;20(6):1701-1708.

PMID: 31244290 DOI: 10.31557/APJCP.2019.20.6.1701

Objective: This report focuses on a private medical centre cancer care performance as measured by patient survival
outcome for up to 5 years. Methods: All patients with nasopharyngeal cancer treated at SJMC between 2008 and 2012
were enrolled for this observational cohort study. Mortality outcome was ascertained through record linkage with
national death register, linkage with hospital registration system and finally through direct contact by phone. Result:
266 patients treated between 2008 and 2012 were included for survival analysis. 31% of patients were diagnosed with
Early NPC Cancer (Stage I or II), another 44% with Locally Advanced Cancer (Stage III) and 25% with late stage IV
metastatic cancer. 2%, 27% and 67% had WHO Class I, II and III NPC respectively. The overall survival at 5 years
was 100% for patients with Stage I disease, 91% for Stage II disease, 72% for Stage III disease, and decreasing to
44% for Stage IV disease. Overall survival at 5 years for all stages was 73%. Conclusion: SJMC is among the first
hospitals in Malaysia to embark on routine measurement of the performance of its cancer care services and its results
are comparable to any leading centers in developed countries.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology

Salivary gland anlage tumour of the nasopharynx: A case report and review for histopathological characteristics

Başak K, Günhan Ö, Akbulut S, Aydin S

Malays J Pathol, 2019 Dec;41(3):345-350.

PMID: 31901920

INTRODUCTION: Congenital salivary gland anlage tumour of the nasopharynx is a lesion which usually presents with nasal and upper respiratory tract obstruction in the neonatal period. Timely diagnosis is essential to prevent the occurrence of respiratory complications in later childhood.

CASE REPORT: We present a 8-year-old boy complaining from difficulty in breathing and breastfeeding in the neonatal period due to an adenoid-like nasopharyngeal mass. Histological examination revealed solid and cystic squamous nests and numerous duct-like structures within collagenised stroma. Both epithelial and myoepithelial differentiation were noted in the tubular component.

DISCUSSION: A review of the clinical and histopathological features of published cases revealed that ancient lesions showed more prominent and complex epithelial component and more collagen rich stroma. We would like to suggest the possibility of salivary gland anlage tumour to be considered in the differential diagnosis of neonatal respiratory distress cases.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Thyroid metastasis from nasopharyngeal carcinoma: a case report

Jalaludin MA, Rajadurai P, Va R, Prasad U

J Laryngol Otol, 1994 Oct;108(10):886-8.

PMID: 7989842 DOI: 10.1017/s0022215100128415

Anaplastic nasopharyngeal carcinoma (NPC) metastatic to the thyroid gland is rare. We report the first such case in a 54-year-old Malaysian Chinese woman. The correct diagnosis should be made so that thyroidectomy may be avoided and an appropriate chemoradiotherapeutic regimen instituted.

Matched MeSH terms: Nasopharyngeal Neoplasms/pathology*

Displaying publications 1 - 20 of 65 in total