Displaying all 7 publications

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  1. Fadzli F, Ramli N, Ramli NM
    Clin Radiol, 2013 Oct;68(10):e538-51.
    PMID: 23932674 DOI: 10.1016/j.crad.2013.05.104
    Visual field defects are a conglomerate of patterns of visual impairment derived from diseases affecting the optic nerve as it extends from the globe to the visual cortex. They are complex signs requiring perimetry or visual confrontation for delineation and are associated with diverse aetiologies. This review considers the chiasmatic and post-chiasmatic causes of visual disturbances, with an emphasis on magnetic resonance imaging (MRI) techniques. Newer MRI sequences are considered, such as diffusion-tensor imaging. MRI images are correlated with perimetric findings in order to demonstrate localization of lesions in the visual pathway. This may serve as a valuable reference tool to clinicians and radiologists in the early diagnostic process of differentiating causes of various visual field defects in daily practice.
    Matched MeSH terms: Optic Nerve Diseases/pathology
  2. Peyman M, Hieng TL, Subrayan V
    BMJ Case Rep, 2011;2011.
    PMID: 22698906 DOI: 10.1136/bcr.11.2010.3517
    Matched MeSH terms: Optic Nerve Diseases/pathology
  3. Prasad U, Doraisamy S
    Eur J Surg Oncol, 1991 Oct;17(5):536-40.
    PMID: 1936303
    Five rare cases of nasopharyngeal carcinoma with optic nerve involvement are reported. Computerised Tomographic Scan (CT Scan) studies were performed in four of them. Evidence of intracranial spread of the tumour, from the roof of the fossa of Rosenmuller to the apex of the orbit through the cavernous sinus, was noted in three patients. In one of them there was extracranial extension of the tumour, to the orbit through the posterior ethmoid.
    Matched MeSH terms: Optic Nerve Diseases/pathology*
  4. Mallika PS, Salowi MA, Thanaraj A, Chong MS, Tan AK, Chua CN
    Med J Malaysia, 2012 Apr;67(2):228-30.
    PMID: 22822654 MyJurnal
    With the pathophysiology not clearly understood and fewer than 130 cases having been reported in the literature, diabetic papillopathy presents a special challenge to the ophthalmologist. We report a case of a young patient with more than 12 years of type 1 diabetes mellitus (T1DM) on insulin with poor compliance to treatment who presented with sudden bilateral loss of vision. Ocular examination, fluorescence angiography (FA) and systemic signs were conclusive of diabetic papillopathy. His fasting blood sugar level was high and serum glycosylated haemoglobin (HbA1c) indicated a long term fluctuating blood glucose control. His vision initially improved with treatment, but later deteriorated with tight glycemic control.
    Matched MeSH terms: Optic Nerve Diseases/pathology
  5. Sidek S, Ramli N, Rahmat K, Ramli NM, Abdulrahman F, Tan LK
    Eur J Radiol, 2014 Aug;83(8):1437-41.
    PMID: 24908588 DOI: 10.1016/j.ejrad.2014.05.014
    To evaluate whether MR diffusion tensor imaging (DTI) of the optic nerve and optic radiation in glaucoma patients provides parameters to discriminate between mild and severe glaucoma and to determine whether DTI derived indices correlate with retinal nerve fibre layer (RNFL) thickness.
    Matched MeSH terms: Optic Nerve Diseases/pathology*
  6. Agarwal R, Agarwal P
    Indian J Ophthalmol, 2012 Jul;60(4):255-61.
    PMID: 22824592 DOI: 10.4103/0301-4738.98700
    Glaucoma, a neurodegenerative disease, is currently being treated by modulation of one of its primary risk factors, the elevated intraocular pressure. Newer therapies that can provide direct neuroprotection to retinal ganglion cells are being extensively investigated. Tumor necrosis factor-α, a cytokine, has been recognized to play an important role in pro and antiapoptotic cellular events. In this paper we review the relevant literature to understand (1) The association of increased expression of tumor necrosis factor-α with glaucomatous neurodegeneraion, (2) Modulation of tumor necrosis factor-α expression by exposure to various risk factors of glaucoma, (3) Downstream cellular signaling mechanisms following interaction of tumor necrosis factor-α with its receptors and (4) Role of tumor necrosis factor-α as a possible target for therapeutic intervention in glaucoma. Literature was reviewed using PubMed search engine with relevant key words and a total of 82 English language papers published from 1990 to 2010 are included in this review.
    Matched MeSH terms: Optic Nerve Diseases/pathology
  7. Moey LH, Flaherty M, Zankl A
    Am J Med Genet A, 2019 09;179(9):1898-1901.
    PMID: 31228225 DOI: 10.1002/ajmg.a.61268
    Matched MeSH terms: Optic Nerve Diseases/pathology
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