Browse publications by year: 2012

  1. Tahir NI, Shaari K, Abas F, Parveez GK, Ishak Z, Ramli US
    J Agric Food Chem, 2012 Nov 14;60(45):11201-10.
    PMID: 23116142 DOI: 10.1021/jf303267e
    The palm oil industry generates several byproducts, and more than half of the dry weight of the waste is of oil palm leaf whereby the tissue is underutilized. Recently, several research studies found promising potential of oil palm fronds as a source of nutraceutical due to its bioactive properties. However, the chemical composition of the tissue is still not deciphered. Using reversed-phase liquid chromatography (LC) electrospray mass spectrometry (ESI-MS), glycosylated apigenin and luteolin were separated and identified from oil palm (Elaeis guineensis Jacq.) leaf and structures of the constituents were elucidated by collision-induced dissociation (CID) tandem MS. From 28 derivatives of the flavones, 9 compounds were conjugated with hydroxymethylglutaric (HMG) acid. Improved knowledge on oil palm especially on bioactive component of the leaf tissue will allow correlation of its beneficial effects and further promotes efficient utilization of this agriculture byproduct.
    MeSH terms: Plant Extracts/chemistry*; Plant Oils/chemistry*; Molecular Structure; Plant Leaves/chemistry; Spectrometry, Mass, Electrospray Ionization/methods; Arecaceae/chemistry*; Apigenin/chemistry*; Luteolin/chemistry*; Chromatography, Reverse-Phase/methods
  2. Jahromi MF, Liang JB, Ho YW, Mohamad R, Goh YM, Shokryazdan P
    J Biomed Biotechnol, 2012;2012:196264.
    PMID: 23118499 DOI: 10.1155/2012/196264
    Ability of two strains of Aspergillus terreus (ATCC 74135 and ATCC 20542) for production of lovastatin in solid state fermentation (SSF) using rice straw (RS) and oil palm frond (OPF) was investigated. Results showed that RS is a better substrate for production of lovastatin in SSF. Maximum production of lovastatin has been obtained using A. terreus ATCC 74135 and RS as substrate without additional nitrogen source (157.07 mg/kg dry matter (DM)). Although additional nitrogen source has no benefit effect on enhancing the lovastatin production using RS substrate, it improved the lovastatin production using OPF with maximum production of 70.17 and 63.76 mg/kg DM for A. terreus ATCC 20542 and A. terreus ATCC 74135, respectively (soybean meal as nitrogen source). Incubation temperature, moisture content, and particle size had shown significant effect on lovastatin production (P < 0.01) and inoculums size and pH had no significant effect on lovastatin production (P > 0.05). Results also have shown that pH 6, 25°C incubation temperature, 1.4 to 2 mm particle size, 50% initial moisture content, and 8 days fermentation time are the best conditions for lovastatin production in SSF. Maximum production of lovastatin using optimized condition was 175.85 and 260.85 mg/kg DM for A. terreus ATCC 20542 and ATCC 74135, respectively, using RS as substrate.
    MeSH terms: Agriculture; Aspergillus/drug effects; Aspergillus/growth & development; Aspergillus/metabolism*; Aspergillus/ultrastructure; Biotechnology/methods*; Chromatography, High Pressure Liquid; Humidity; Hydrogen-Ion Concentration/drug effects; Lignin/metabolism; Lovastatin/analysis; Lovastatin/biosynthesis*; Lovastatin/chemistry; Minerals/pharmacology; Nitrogen/pharmacology; Particle Size; Plant Oils/metabolism*; Oryza/drug effects; Oryza/metabolism*; Solutions; Substrate Specificity/drug effects; Temperature; Time Factors; Biomass*; Biosynthetic Pathways/drug effects
  3. Muhammad N, Luke DA, Shuid AN, Mohamed N, Soelaiman IN
    PMID: 23118785 DOI: 10.1155/2012/161527
    Postmenopausal osteoporotic bone loss occurs mainly due to cessation of ovarian function, a condition associated with increased free radicals. Vitamin E, a lipid-soluble vitamin, is a potent antioxidant which can scavenge free radicals in the body. In this study, we investigated the effects of alpha-tocopherol and pure tocotrienol on bone microarchitecture and cellular parameters in ovariectomized rats. Three-month-old female Wistar rats were randomly divided into ovariectomized control, sham-operated, and ovariectomized rats treated with either alpha-tocopherol or tocotrienol. Their femurs were taken at the end of the four-week study period for bone histomorphometric analysis. Ovariectomy causes bone loss in the control group as shown by reduction in both trabecular volume (BV/TV) and trabecular number (Tb.N) and an increase in trabecular separation (Tb.S). The increase in osteoclast surface (Oc.S) and osteoblast surface (Ob.S) in ovariectomy indicates an increase in bone turnover rate. Treatment with either alpha-tocopherol or tocotrienol prevents the reduction in BV/TV and Tb.N as well as the increase in Tb.S, while reducing the Oc.S and increasing the Ob.S. In conclusion, the two forms of vitamin E were able to prevent bone loss due to ovariectomy. Both tocotrienol and alpha-tocopherol exert similar effects in preserving bone microarchitecture in estrogen-deficient rat model.
    MeSH terms: Animals; Antioxidants; Estrogens; Female; Femur; Free Radicals; Humans; Lipids; Osteoblasts; Osteoclasts; Ovariectomy; Vitamin E; Vitamins; Osteoporosis, Postmenopausal; Bone Remodeling; Rats, Wistar; Postmenopause; alpha-Tocopherol; Tocotrienols; Control Groups; Rats
  4. Naina Mohamed I, Borhanuddin B, Shuid AN, Mohd Fozi NF
    PMID: 23118786 DOI: 10.1155/2012/250584
    Purpose. This paper explores the effects of vitamin E on bone structural changes. Methods. A systematic review of the literature was conducted to identify relevant studies about vitamin E and osteoporosis/bone structural changes. A comprehensive search in Medline and CINAHL for relevant studies published between the years 1946 and 2012 was conducted. The main inclusion criteria were published in English, studies had to report the association or effect of vitamin E and osteoporosis-related bone changes, and the osteoporosis-related bone changes should be related to lifestyle variables, aging, or experimentally-induced conditions. Results. The literature search identified 561 potentially relevant articles, whereby 11 studies met the inclusion criteria. There were three human epidemiological studies and eight animal experimental studies included in this paper. Four animal studies reported positive bone structural changes with vitamin E supplementation. The rest of the studies had negative changes or no effect. Studies with positive changes reported better effects with tocotrienol vitamin E isomer supplementation. Conclusions. This evidence-based review underscores the potential of vitamin E being used for osteoporosis. The effect of one of the vitamin E isomers, tocotrienols, on bone structural changes warrants further exploration. Controlled human observational studies should be conducted to provide stronger evidence.
    MeSH terms: Animals; Bone and Bones; Humans; Life Style; Osteoporosis; Vitamin E; Epidemiologic Studies; Dietary Supplements; Tocotrienols; Animal Experimentation
  5. Soyiri IN, Reidpath DD
    PLoS One, 2012;7(10):e47823.
    PMID: 23118897 DOI: 10.1371/journal.pone.0047823
    The concept of forecasting asthma using humans as animal sentinels is uncommon. This study explores the plausibility of predicting future asthma daily admissions using retrospective data in London (2005-2006). Negative binomial regressions were used in modeling; allowing the non-contiguous autoregressive components. Selected lags were based on partial autocorrelation function (PACF) plot with a maximum lag of 7 days. The model was contrasted with naïve historical and seasonal models. All models were cross validated. Mean daily asthma admission in 2005 was 27.9 and in 2006 it was 28.9. The lags 1, 2, 3, 6 and 7 were independently associated with daily asthma admissions based on their PACF plots. The lag model prediction of peak admissions were often slightly out of synchronization with the actual data, but the days of greater admissions were better matched than the days of lower admissions. A further investigation across various populations is necessary.
    MeSH terms: Air Pollution; Animals; Forecasting; Health Services*; Hospital Records; Humans; London; Models, Theoretical*; Retrospective Studies; Seasons
  6. Nur Aqilah MY, Juliana J
    Glob J Health Sci, 2012 Nov;4(6):160-9.
    PMID: 23121752 DOI: 10.5539/gjhs.v4n6p160
    There was considerable evidence that a subject's psychological status may influence respiratory sensations and that some subjects may experience respiratory symptoms regardless of the presence of a respiratory disease. The objective of this study was to determine the association between occupational stress and respiratory symptoms among lecturers. This cross sectional study was conducted in Universiti Putra Malaysia, involved 61 lecturers from various faculties. Job Content Questionnaire (JCQ) and questionnaires based on American Thoracic Society were used to collect the data on socio-demography, stress level and respiratory symptoms. High level of occupational stress (high strain) was determined among 16 of the respondents (26.2%). Breathlessness was the common symptom experienced by the respondents. Female lecturers were significantly experienced high stress level compared to male (p=0.035). They were also significantly having more breathlessness symptom compared to male lecturer (p=0.011). Study highlighted in study population, gender plays a significant role that influenced level of occupational stress and also gender has role in resulting occupational stress level and respiratory symptoms. There was no significant association between occupational stress and respiratory symptoms. It can be concluded that this group of lecturers of Universiti Putra Malaysia did not experienced high occupational stress level. Occupational stress level was not statistically significantly associated with all respiratory symptoms being studied.
    MeSH terms: Adult; Cross-Sectional Studies; Female; Humans; Malaysia/epidemiology; Male; Middle Aged; Occupational Diseases/epidemiology*; Respiratory Tract Diseases/epidemiology*; Sex Factors; Social Support; Socioeconomic Factors; Stress, Psychological/epidemiology*; Universities/statistics & numerical data*
  7. Widyahening IS, van der Heijden GJMG, Ming Moy F, van der Graaf Y, Sastroasmoro S, Bulgiba A
    Med Educ Online, 2012 Jan;17(1):19623.
    PMID: 28440118 DOI: 10.3402/meo.v17i0.19623
    INTRODUCTION: We report about the direct short-term effects of a Clinical Epidemiology and Evidence-based Medicine (CE-EBM) module on the knowledge, attitude, and behavior of students in the University Medical Center Utrecht (UMCU), Universitas Indonesia (UI), and University of Malaya (UM).

    METHODS: We used an adapted version of a 26-item validated questionnaire, including four subscales: knowledge, attitude, behavior, and future use of evidence-based practice (EBP). The four components were compared among the students in the three medical schools before the module using one-way ANOVA. At the end of the module, we measured only knowledge and attitudes. We computed Cronbach's α to assess the reliability of the responses in our population. To assess the change in knowledge and attitudes, we used the paired t-test in the comparison of scores before and after the module.

    RESULTS: In total, 526 students (224 UI, 202 UM, and 100 UMCU) completed the questionnaires. In the three medical schools, Cronbach's α for the pre-module total score and the four subscale scores always exceeded 0.62. UMCU students achieved the highest pre-module scores in all subscales compared to UI and UM with the comparison of average (SD) score as the following: knowledge 5.04 (0.4) vs. 4.73 (0.69) and 4.24 (0.74), p<0.001; attitude 4.52 (0.64) vs. 3.85 (0.68) and 3.55 (0.63), p<0.001; behavior 2.62 (0.55) vs. 2.35 (0.71) and 2.39 (0.92), p=0.016; and future use of EBP 4.32 (0.59) vs. 4.08 (0.62) and 3.7 (0.71), p<0.01. The CE-EBM module increased the knowledge of the UMCU (from average 5.04±0.4 to 5.35±0.51; p<0.001) and UM students (from average 4.24±0.74 to 4.53±0.72; p<0.001) but not UI. The post-module scores for attitude did not change in the three medical schools.

    CONCLUSION: EBP teaching had direct short-term effects on knowledge, not on attitude. Differences in pre-module scores are most likely related to differences in the system and infrastructure of both medical schools and their curriculum.

  8. Anuar TS, Al-Mekhlafi HM, Abdul Ghani MK, Abu Bakar E, Azreen SN, Salleh FM, et al.
    Int J Parasitol, 2012 Dec;42(13-14):1165-75.
    PMID: 23123168 DOI: 10.1016/j.ijpara.2012.10.003
    Currently, species-specific information on Entamoeba infections is unavailable in Malaysia and is restricted worldwide due to the re-description of pathogenic Entamoeba histolytica and non-pathogenic Entamoeba dispar and Entamoeba moshkovskii. Therefore, this cross-sectional study was conducted to provide the first known documented data on the true prevalence of these three species in western Malaysia using a molecular method. Another aim of this study was to determine the association of potential risk factors associated with each Entamoeba sp. A total of 500 stool samples from three Orang Asli tribes were randomly collected. The overall prevalence of E. histolytica, E. dispar and E. moshkovskii determined by microscopy was 18.6% (93/500). Molecular analysis revealed that while most Entamoeba-positive individuals were infected with E. dispar (13.4%), followed by E. histolytica (3.2%) and E. moshkovskii (1.0%), the present findings show low prevalence rates of mixed infections with E. histolytica and E. dispar (2%), E. dispar and E. moshkovskii (1.2%) and association infections of E. histolytica, E. dispar and E. moshkovskii (0.4%). Logistical regression analysis indicates that the dynamics of the transmission of the three Entamoeba spp. was different. Of six statistically significant variables observed in the univariate analysis, three were retained as significant risk factors for E. histolytica infection in the logistical regression model. These factors were (i) not washing hands after playing with soil or gardening (Odds ratio (OR)=4.7; 95% confidence level (CI)=1.38, 16.14; P=0.013), (ii) indiscriminate defecation in the river or bush (OR=5.7; 95% CI=1.46, 21.95; P=0.012) and (iii) close contact with domestic animals (OR=5.4; 95% CI=1.36, 2.51; P=0.017). However, subjects with family members who were infected with E. histolytica/E. dispar/E. moshkovskii (OR=3.8; 95 CI=2.11, 6.86; P<0.001) and those who consumed raw vegetables (OR=1.8; 95% CI=1.01, 3.23; P=0.047) were more likely to be infected with E. dispar. On the other hand, no associated factor was identified with E. moshkovskii infection. Nevertheless, diarrhoea (P=0.002) and other gastroenteritis symptoms (P<0.001) were only associated with E. histolytica infection. The present study provides new insight into the distribution and risk factors of E. histolytica, E. dispar and E. moshkovskii infections among Orang Asli communities in Malaysia. Identifying the different risk factors of E. histolytica and E. dispar infections will help in the planning specific strategies in the control and prevention of each infection in the communities. Moreover, it emphasises the need for molecular methods to determine the species-specific prevalence of Entamoeba spp.
    MeSH terms: Adolescent; Amebiasis/epidemiology*; Animals; Entamoeba/classification*; Entamoeba/isolation & purification; Feces/parasitology; Female; Humans; Malaysia; Male; Population Surveillance; Risk Factors; DNA, Protozoan/genetics; Genomics
  9. Subramaniam TS, Lee HL, Ahmad NW, Murad S
    Biotechnol J, 2012 Nov;7(11):1323-7.
    PMID: 23125042 DOI: 10.1002/biot.201200282
    On December 21, 2010, 6000 genetically modified (GM) mosquitoes were released in an uninhabited forest in Malaysia. The purpose of the deliberate release was a limited “marked release and recapture” (MRR) experiment, a standard ecological method in entomology, to evaluate under field conditions, the flight distance and longevity of the sterile male Aedes aegypti strain OX513A(My1), a GM strain. As with any other GM technologies, the release was received with mixed responses. As the scientific community debate over the public engagement strategies for similar GM releases, dengue incidence continues to rise with a heavy toll on morbidity, mortality and healthcare budgets. Meanwhile the wild female Aedes aegypti continues to breed offspring, surviving and evading conventional interventions for vector control.
    MeSH terms: Aedes/genetics*; Animals; Biotechnology; Feedback; Female; Humans; Health Knowledge, Attitudes, Practice; Malaysia; Male; Pest Control, Biological/methods*; Public Health/instrumentation; Public Health/methods*; Public Relations; Animals, Genetically Modified*; Information Dissemination*
  10. Taha M, Naz H, Rahman AA, Ismail NH, Yousuf S
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2846.
    PMID: 23125650 DOI: 10.1107/S1600536812036550
    The title compound, C(15)H(14)N(2)O(5)·CH(3)OH, displays an E conformation about the azomethine double bond [C=N = 1.277 (2) Å] and the benzene rings are inclined to one another by 18.28 (9)°. An intra-molecular O-H⋯O hydrogen bond occurs between the para-OH group and one of the meta-O atoms of the 3,4,5-trihy-droxy-benzyl-idene group. In the crystal, the components are linked into a three dimensional network by O-H⋯O, O-H⋯N and C-H⋯O hydrogen bonds.
  11. Ali AQ, Eltayeb NE, Teoh SG, Salhin A, Fun HK
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2868-9.
    PMID: 23125668 DOI: 10.1107/S1600536812036471
    In the title compound, C(11)H(11)FN(4)OS, an intra-molecular N-H⋯O hydrogen bond generates an S(6) ring. In the crystal, mol-ecules form chains through N-H⋯O hydrogen bonds, which are extended by N-H⋯S hydrogen bonds into an infinite three-dimensional network.
  12. Wei AC, Ali MA, Choon TS, Arshad S, Razak IA
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2907-8.
    PMID: 23125700 DOI: 10.1107/S1600536812037993
    In the title compound, C(27)H(20)BrNO(3), two intra-molecular C-H⋯O hydrogen bonds both form S(6) rings. The pyrrolidine ring adopts a twisted conformation about the C-C bond bearing the indane ring systems. The other two five-membered rings within the indane systems are in shallow envelope conformations, with the spiro C atoms as the flap atoms. The mean plane of the pyrrolidine ring [maximum deviation = 0.275 (1) Å] makes dihedral angles of 65.25 (7), 78.33 (6) and 75.25 (6)° with the bromo-substituted benzene ring and the mean planes of the mono- and dioxo-substituted indane rings, respectively. In the crystal, mol-ecules are linked by C-H⋯O and C-H⋯N hydrogen bonds into a three-dimensional network. In addition, C-H⋯π inter-actions are observed.
  13. Fadzillah SM, Ngaini Z, Hussain H, Razak IA, Asik SI
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2909.
    PMID: 23125701 DOI: 10.1107/S1600536812038007
    In the title compound, C(21)H(24)O(3), the enone moiety adopts an s-cis conformation and the dihedral angle between the benzene rings is 12.89 (6)°. The hex-yloxy tail adopts an extended conformation. In the crystal, inversion dimers are linked by pairs of O-H⋯O hydrogen bonds and pairs of C-H⋯O inter-actions, forming two R(2) (2)(7) and one R(2) (2)(10) loops. The dimers are then arranged into sheets lying parallel to (201) and weak C-H⋯π inter-actions consolidate the packing.
  14. Thanigaimani K, Razak IA, Arshad S, Jagatheesan R, Santhanaraj KJ
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2910.
    PMID: 23125702 DOI: 10.1107/S1600536812038019
    In the title compound, C(10)H(11)N(5)O, the triazine ring forms a dihedral angle of 10.37 (4)° with the benzene ring. In the crystal, adjacent mol-ecules are linked by a pair of N-H⋯N hydrogen bonds, forming an inversion dimer with an R(2) (2)(8) ring motif. The dimers are further connected via N-H⋯O and N-H⋯N hydrogen bonds, resulting in a three-dimensional network.
  15. Fadzillah SM, Ngaini Z, Hussain H, Razak IA, Asik SI
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2911-2.
    PMID: 23125703 DOI: 10.1107/S1600536812038020
    In the title compound, C(29)H(40)O(3), the enone moiety adopts an s-cis conformation. The dihedral angle between the benzene rings is 4.33 (5)° The least-squares mean line through the tetra-decyl side chain forms a dihedral angle of 83.99 (7)° with the normal to the attached benzene ring. In the crystal, O-H⋯O and C-H⋯O hydrogen bonds involving the keto and the hy-droxy O atoms form ribbons along [-41-1]. The crystal structure also features C-H⋯π inter-actions.
  16. Ngaini Z, Fadzillah SM, Hussain H, Razak IA, Asik SI
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2935-6.
    PMID: 23125722 DOI: 10.1107/S160053681203872X
    In the title compound, C(25)H(32)O(3), the enone group adopts an s-cis conformation. The alk-oxy chain is in an all-trans conformation. The dihedral angle between the benzene rings is 7.86 (5)°. In the crystal, mol-ecules are connected by pairs of O-H⋯O hydrogen bonds, forming inversion dimers and giving R(2) (2)(10) rings. Within these dimers, weak C-H⋯O hydrogen bonds form two R(2) (2)(7) rings. In the crystal, the approximately planar mol-ecules [largest deviation for an atom being 0.4737 (12) Å for the terminal C atom of the alk-oxy chain] are arranged in sheets parallel to (20-1). Weak C-H⋯π inter-actions are also observed.
  17. Thanigaimani K, Razak IA, Arshad S, Jagatheesan R, Santhanaraj KJ
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2938-9.
    PMID: 23125724 DOI: 10.1107/S1600536812038743
    The asymmetric unit of the title compound, 2C(10)H(11)N(5)O·C(6)H(10)O(4), consists of a 2,4-diamino-6-(4-meth-oxy-phen-yl)-1,3,5-triazine mol-ecule and one-half mol-ecule of adipic acid which lies about an inversion center. The triazine ring makes a dihedral angle of 12.89 (4)° with the adjacent benzene ring. In the crystal, the components are linked by N-H⋯O and O-H⋯N hydrogen bonds, thus generating a centrosymmetric 2 + 1 unit of triazine and adipic acid mol-ecules with R(2) (2)(8) motifs. The triazine mol-ecules are connected to each other by N-H⋯N hydrogen bonds, forming an R(2) (2)(8) motif and a supra-molecular ribbon along the c axis. The 2 + 1 units and the supra-molecular ribbons are further inter-linked by weak N-H⋯O, C-H⋯O and C-H⋯π inter-actions, resulting in a three-dimensional network.
  18. Rahman ML, Kwong HC, Mohd Yusoff M, Hegde G, Mohamed Tahir MI, Rahman MZ
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2958.
    PMID: 23125741 DOI: 10.1107/S1600536812038718
    The title compound, C(17)H(16)N(2)O(3), has an E conformation about the azobenzene (-N=N-) linkage. The benzene rings are twisted slightly with respect to each other [6.79 (9)°], while the dihedral angle between the plane through the carb-oxy group and the attached benzene ring is 3.2 (2)°. In the crystal, mol-ecules are oriented with the carb-oxy groups head-to-head, forming O-H⋯O hydrogen-bonded inversion dimers. These dimers are connected by C-H⋯O hydrogen-bonds into layers lying parallel to the (013) plane.
  19. Yoon YK, Ali MA, Choon TS, Arshad S, Razak IA
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2967-8.
    PMID: 23125749 DOI: 10.1107/S1600536812039268
    The asymmetric unit of the title compound, C(27)H(32)N(4)O(4)·H(2)O, contains two independent benzimidazole-5-carboxyl-ate mol-ecules and two water mol-ecules. In both main mol-ecules, the pyrrolidine rings are in an envelope conformation with a methyl-ene C atom as the flap. The morpholine rings adopt chair conformations. Both benzimidazole rings are essentially planar, with maximum deviations of 0.008 (1) Å, and form dihedral angles of 37.65 (6) and 45.44 (6)° with the benzene rings. In one mol-ecule, an intra-molecular C-H⋯O hydrogen bond forms an S(7) ring motif. In the crystal, O-H⋯O and O-H⋯N hydrogen bonds connect pairs of main mol-ecules and pairs of water mol-ecules into two independent centrosymmetric four-compoment aggregates. These aggregates are connect by C-H⋯O hydrogen bonds leading to the formation of a three-dimensional network, which is stabilized by C-H⋯π interactions.
  20. Fun HK, Loh WS, Viveka S, Dinesha, Nagaraja GK
    Acta Crystallogr Sect E Struct Rep Online, 2012 Oct 1;68(Pt 10):o2987.
    PMID: 23125762 DOI: 10.1107/S1600536812039645
    In the cation of the title compound, C(9)H(12)NO(2) (+)·Cl(-), the dihedral angle between the 2-oxoethanaminium N-C-C(=O)- plane [maximum deviation = 0.0148 (12) Å] and the benzene ring is 7.98 (8)°. The meth-oxy group is approximately in-plane with the benzene ring, with a C-O-C-C torsion angle of -2.91 (18)°. In the crystal, the cations and chloride anions are connected by N-H⋯Cl and C-H⋯Cl hydrogen bonds, forming a layer parallel to the bc plane. A C-H⋯π inter-action further links the layers.
External Links