Browse publications by year: 2012

  1. Farina MY, Harunarashid H, Faridzal F, Jegan T, Das S
    Clin Ter, 2012 Nov;163(6):491-3.
    PMID: 23306743
    The availability of multiple investigating modalities should be utilized to arrive at the correct diagnosis of the spinal arteriovenous malformation (AVM). We hereby report the case of a 21-year-old, obese female, who presented with paraplegia and impaired bowel control two years after an episode of the fall. The Magnetic Resonance Imaging (MRI) of her spine not only revealed disc prolapse at T11-T12, but also tortuous dilated spinal veins and cord oedema. A diagnosis of a spinal arterio-venous fistula was confirmed after a spinal angiogram. The dilemma of treating the right pathology for the clinical signs and symptoms are being discussed.
    MeSH terms: Arteriovenous Malformations/complications*; Arteriovenous Malformations/diagnosis*; Female; Humans; Intervertebral Disc Displacement/etiology*; Lumbar Vertebrae*; Spinal Cord/blood supply*; Thoracic Vertebrae*; Young Adult
  2. Razman J, Azlanudin A, Eyad AJ, Zahiah M, Das S
    Clin Ter, 2012 Nov;163(6):495-7.
    PMID: 23306744
    Mature cystic teratomas of the pancreas are extremely rare tumours encountered in day-to-day clinical practice. Only few cases have been reported to date involving all age groups. The management, diagnosis and evaluation of this tumor are questionable, with definitive diagnosis taking place intra-operatively. We hereby report the case in a 30 year-old-male who presented with newly diagnosed diabetes mellitus and during the follow up he was noted to have elevated liver enzymes clinically, he was asymptomatic. The computerized tomography revealed a retropancreatic mass and pushing the mesenteric veins anteriorly. The mass was hypodense in nature and there was presence of calcification. Although the patient was asymptomatic, the decision for resecting the mass was made in view of the size and possibility of malignancy. In conclusion, considering the size and approximity of the mass to the pancreas, Whipple procedure's is the most appropriate approach although the histological diagnosis has not been established preoperatively.
    MeSH terms: Adult; Humans; Male; Pancreatic Neoplasms/pathology*; Pancreatic Neoplasms/surgery; Teratoma/pathology*; Teratoma/surgery
  3. Taty-Anna K, Farihah HS, Norzana AG, Farida H, Das S
    Clin Ter, 2012 Nov;163(6):503-4.
    PMID: 23306746
    The right and left lobes of the thyroid gland are connected by an isthmus. The isthmus lies at the level of the second and third tracheal rings. Occasionaly, the isthmus may be absent. We hereby, report the absence of isthmus in a 52-year-old male cadaver of unknown origin. Both the right and left lobes were normal but they were separated. Both the right and left lobes of the thyroid gland measured 4.3 cm vertically. The separation distance between right and left glands was noted at the upper, middle and lower parts. The upper end of medial border of both lobes were separated by a distance of 1 cm while the separation distance was 0.7 cm and 1.5 cm at the middle and lower parts, respectively. The anatomical and clinical significance of absence of isthmus is important for medical personnel and the surgeons operating on the thyroid gland. The present case report is a an attempt to highlight such.
    MeSH terms: Cadaver; Humans; Male; Middle Aged; Thyroid Gland/abnormalities*
  4. Zar CT, Teoh SL, Das S, Zaiton Z, Farihah HS
    Clin Ter, 2012 Nov;163(6):505-10.
    PMID: 23306747
    Herbs with antidiabetic activity have a potential role to play. Herbal medicines have been widely used in South East Asia because of lesser side effects and cost effectiveness. The main aim of this review article was to disseminate important information regarding the use of herbal products in oxidative stress involved in diseases like diabetes mellitus. The article highlights some of the traditional medicinal plants which have been widely used in South East Asia with special emphasis on Piper sarmentosum. Piper sarmentosum have been reported to possess varying degree of hypoglycemic, antidiabetic and other additional properties. The antioxidant properties of the herbs may be effective in controlling the oxidative damage produced during diabetes mellitus. The review article highlights the positive role of traditional herbs towards diabetes mellitus and also describes its complications.
    MeSH terms: Asia, Southeastern; Diabetes Mellitus/drug therapy*; Humans; Hypoglycemic Agents/therapeutic use; Phytotherapy*; Plant Extracts/therapeutic use*; Plants, Medicinal; Piper*
  5. Al-Samarrai G, Singh H, Syarhabil M
    Ann Agric Environ Med, 2012;19(4):673-6.
    PMID: 23311787
    Fungicides are widely used in conventional agriculture to control plant diseases. Prolonged usage often poses health problems as modern society is becoming more health-conscious. Penicillium digitatum, the cause of citrus green mould, is an important postharvest pathogen which causes serious losses annually. The disease is currently managed with synthetic fungicides. There is, however, a growing concern globally about the continuous use of synthetic chemicals on food crops because of their potential effects on human health and the environment.
    MeSH terms: Animals; Artemia/drug effects*; Conservation of Natural Resources*; Dose-Response Relationship, Drug; Fungicides, Industrial/pharmacology; Fungicides, Industrial/toxicity; Fungicides, Industrial/chemistry*; Lethal Dose 50; Penicillium/drug effects*; Plant Extracts/pharmacology; Plant Extracts/toxicity; Plant Extracts/chemistry*; Colony Count, Microbial; Angiosperms/chemistry*
  6. Yeo KS, Mohidin TB, Ng CC
    C. R. Biol., 2012 Dec;335(12):713-21.
    PMID: 23312294 DOI: 10.1016/j.crvi.2012.11.002
    Epstein-Barr virus (EBV) is a ubiquitous tumor-causing virus which infects more than 90% of the world population asymptomatically. Recent studies suggest that LMP-1, -2A and -2B cooperate in the tumorigenesis of EBV-associated epithelial cancers such as nasopharygeal carcinoma, oral and gastric cancer. In this study, LMPs were expressed in the HEK293T cell line to reveal their oncogenic mechanism via investigation on their involvement in the regulation of the cell cycle and genes that are involved. LMPs were expressed in HEK293T in single and co-expression manner. The transcription of cell cycle arrest genes were examined via real-time PCR. Cell cycle progression was examined via flow cytometry. 14-3-3σ and Reprimo were upregulated in all LMP-1 expressing cells. Moreover, cell cycle arrest at G(2)/M progression was detected in all LMP-1 expressing cells. Therefore, we conclude that LMP-1 may induce cell cycle arrest at G(2)/M progression via upregulation of 14-3-3σ and Reprimo.
    MeSH terms: Herpesvirus 4, Human/genetics; Exonucleases/genetics*; Exonucleases/metabolism; Exoribonucleases; Glycoproteins/genetics*; Humans; Neoplasms, Glandular and Epithelial/virology; Biomarkers, Tumor/genetics*; Biomarkers, Tumor/metabolism; Viral Matrix Proteins/pharmacology*; Up-Regulation/drug effects*; Cell Cycle Proteins/genetics*; Epstein-Barr Virus Infections; 14-3-3 Proteins/genetics*; 14-3-3 Proteins/metabolism; HEK293 Cells; Cell Cycle Checkpoints/genetics*; G2 Phase Cell Cycle Checkpoints/genetics; M Phase Cell Cycle Checkpoints/genetics; Real-Time Polymerase Chain Reaction
  7. Muralidharan S
    ISRN Pharm, 2012;2012:451481.
    PMID: 23316393 DOI: 10.5402/2012/451481
    Pharmacokinetic-pharmacodynamic (PK-PD) modeling has emerged as a major tool in clinical pharmacology to optimize drug use by designing rational dosage forms and dosage regimes. Quantitative representation of the dose-concentration-response relationship should provide information for the prediction of the level of response to a certain level of drug dose. This paper describes the experimental details of the preformulation study, tablet manufacture, optimization, and bioanalytical methods for the estimation of dexibuprofen in human plasma. The hydrophilic matrix was prepared with xanthen gum with additives Avicel PH 102. The effect of the concentration of the polymer and different filler, on the in vitro drug release, was studied. Various pharmacokinetic parameters including AUC(0-t), AUC(0-∞), C(max), T(max), T(1/2), and elimination rate constant (K(el)) were determined from the plasma concentration of both formulations of test (dexibuprofen 300 mg) and reference (dexibuprofen 300 mg tablets). The merits of PK-PD in the development of dosage forms and how PK-PD model development necessitates the development of new drugs and bio analytical method development and validation are discussed. The objectives of the present study, namely, to develop and validate the methods to estimate the selected drugs in the biological fluids by HPLC, the development of in vitro dissolution methods, and PK-PD model development have been described.
  8. Al-Naggar RA, Jawad AA, Bobryshev YV
    Asian Pac J Cancer Prev, 2012;13(11):5539-43.
    PMID: 23317214
    OBJECTIVE: The smoking prevalence in Malaysia is high, especially among men and adolescents. This study aimed to determine the prevalence and associated factors towards cigarette smoking among school teachers in Malaysia.

    METHODOLOGY: This study was a school-based cross-sectional study conducted among 495 secondary school teachers. The questionnaire used in this study consisted of 29 questions categorized into two sections: socio-demographic characteristics and smoking behaviour. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) program 13.0. ANOVA; t-tests were used in univariate analysis; multiple linear regression was applied for multivariate analysis.

    RESULTS: The majority of the participants were female (81.6%), in the age group ranged between 30-39 years (44%), Malay (90.1%), married (89.7%), degree holders (85.1%), with monthly income ranged between 3000-3999 Ringgit Malaysia (33.5%), from urban areas (94.7%), their specialty is social studies (33.9%) and with no family history of cancer (83.6%). The prevalence of smoking among school teachers in Malaysia was found to be 7.8%. Regarding reasons to start smoking among school teachers: the major reason was found to be relaxation (33.3%), followed by stress-relief (28.2%). Univariate analysis showed that sex, educational status, monthly income and residency were significantly associated with smoking among school teachers (p<0.001, p=0.004, p=0.031, p=0.010; respectively). Multivariate analysis showed that gender and marital status were significantly associated with smoking among school teachers (p<0.001, p=0.033; respectively).

    CONCLUSION: The prevalence of smoking among school teachers in Malaysia was found to be relatively low. Sex, marital status, educational status, monthly income and residency were significantly associated with smoking among school teachers.

    MeSH terms: Adolescent; Adult; Cross-Sectional Studies; Faculty/statistics & numerical data*; Female; Humans; Malaysia/epidemiology; Male; Middle Aged; Prognosis; Surveys and Questionnaires; Risk Factors; Schools; Smoking/epidemiology*; Prevalence; Young Adult
  9. Al-Naggar RA, Bobryshev YV
    Asian Pac J Cancer Prev, 2012;13(11):5627-32.
    PMID: 23317228
    BACKGROUND: The aim of the study was to determine the prevalence of shisha smoking and associated factors among medical students in Malaysia.

    MATERIALS AND METHODS: A cross-sectional study was conducted at the Management and Science University from December 2011 until March 2012. The questionnaire consisted of five sections including socio-demographic, social environment, knowledge about shisha, psychosocial factors, and personal shisha smoking behavior. Obtained data were analyzed using Statistical Package for the Social Sciences (SPSS 13). T-test was used to determine the relationships between shisha smoking and socio-demographic characteristic.

    RESULTS: A total number of 300 medical students participated in this study. Mean age was 22.5±2.5 years. The majority were female, Malay, single, from urban areas (67%, 54%, 97%, 73%; respectively). The prevalence of shisha smoking among medical students was found to be 20%. The study revealed that many students believed that shisha does not contains nicotine, carbon monoxide, does not lead to lung cancer, dental problems and does not lead to cardiovascular diseases (25%, 20.7%, 22.3%, 29%, 26.7%; respectively). Age and sex were found to be significantly associated with smoking shisha status among medical students (p=0.029, p<0.001; respectively). Furthermore, having parents, siblings and friends smokers of shisha were found to be significantly associated with shisha smoking status (p<0.001, p<0.001, p<0.001; respectively). Furthermore, family problems, problems with friends, financial problems and university life were found to significantly associated with shisha smoking status among medical students (p<0.001, p=0.002, p<0.001, p=0.002; respectively).

    CONCLUSIONS: There is a high prevalence of shisha smoking and a poor knowledge about its impact on health among medical students. More attention is needed to focus on medical education in this regard. The policies that are currently employed in order to reduce the cigarettes smoking should be applied to shisha smoking and shisha products.
    MeSH terms: Adolescent; Adult; Age Factors; Cross-Sectional Studies; Female; Humans; Health Knowledge, Attitudes, Practice*; Malaysia/epidemiology; Male; Prognosis; Surveys and Questionnaires; Risk Factors; Smoking/epidemiology*; Smoking/psychology; Social Environment; Students, Medical/psychology*; Prevalence; Young Adult
  10. Tan FL, Loh SY, Su TT, Veloo VW, Ng LL
    Asian Pac J Cancer Prev, 2012;13(11):5791-7.
    PMID: 23317258
    INTRODUCTION: Return-to-work (RTW) can be a problematic occupational issue with detrimental impact on the quality of life of previously-employed breast cancer survivors. This study explored barriers and facilitators encountered during the RTW process in the area of cancer survivorship.

    MATERIALS AND METHODS: Six focus groups were conducted using a semi-structured interview guide on 40 informants (employed multiethnic survivors). Survivors were stratified into three groups for successfully RTW, and another three groups of survivors who were unable to return to work. Each of the three groups was ethnically homogeneous. Thematic analysis using a constant comparative approach was aided by in vivo software.

    RESULTS: Participants shared numerous barriers and facilitators which directly or interactively affect RTW. Key barriers were physical-psychological after-effects of treatment, fear of potential environment hazards, high physical job demand, intrusive negative thoughts and overprotective family. Key facilitators were social support, employer support, and regard for financial independence. Across ethnic groups, the main facilitators were financial-independence (for Chinese), and socialisation opportunity (for Malay). A key barrier was after-effects of treatment, expressed across all ethnic groups.

    CONCLUSIONS: Numerous barriers were identified in the non-RTW survivors. Health professionals and especially occupational therapists should be consulted to assist the increasing survivors by providing occupational rehabilitation to enhance RTW amongst employed survivors. Future research to identify prognostic factors can guide clinical efforts to restore cancer survivors to their desired level/type of occupational functioning for productivity and wellbeing.

    MeSH terms: Adolescent; Adult; Breast Neoplasms/psychology*; Breast Neoplasms/rehabilitation; Employment; Ethnic Groups/psychology*; Female; Humans; Middle Aged; Motivation; Prognosis; Quality of Life; Social Support; Focus Groups; Survivors/psychology*; Qualitative Research*; Young Adult; Return to Work*
  11. Xian TK, Omar NA, Ying LW, Hamzah A, Raj S, Jaarin K, et al.
    PMID: 23320039 DOI: 10.1155/2012/828170
    Background. Palm oil is commonly consumed in Asia. Repeatedly heating the oil is very common during food processing. Aim. This study is aimed to report on the risk of atherosclerosis due to the reheated oil consumption. Material and Methods. Twenty four male Sprague Dawley rats were divided into control, fresh-oil, 5 times heated-oil and 10 times heated-oil feeding groups. Heated palm oil was prepared by frying sweet potato at 180°C for 10 minutes. The ground standard rat chows were fortified with the heated oils and fed it to the rats for six months. Results. Tunica intima thickness in aorta was significantly increased in 10 times heated-oil feeding group (P < 0.05), revealing a huge atherosclerotic plaque with central necrosis projecting into the vessel lumen. Repeatedly heated oil feeding groups also revealed atherosclerotic changes including mononuclear cells infiltration, thickened subendothelial layer, disrupted internal elastic lamina and smooth muscle cells fragmentation in tunica media of the aorta. Conclusion. The usage of repeated heated oil is the predisposing factor of atherosclerosis leading to cardiovascular diseases. It is advisable to avoid the consumption of repeatedly heated palm oil.
    MeSH terms: Animals; Aorta; Asia; Cardiovascular Diseases; Food Handling; Heating; Male; Causality; Rats, Sprague-Dawley; Tunica Intima; Tunica Media; Ipomoea batatas; Myocytes, Smooth Muscle; Atherosclerosis; Rats; Plaque, Atherosclerotic
  12. Lim PS, Atan IK, Naidu A
    Case Rep Obstet Gynecol, 2012;2012:727146.
    PMID: 23320216 DOI: 10.1155/2012/727146
    Genitourinary tuberculosis is one of the common forms of extrapulmonary tuberculosis. We report a case of atypical genitourinary tuberculosis: massive uterovaginal prolapse with cervical lesion mimicking cervical carcinoma. This particular case highlights the problem of healthcare in most of the developing countries. Lack of patient education, awareness, and access to a healthcare system resulted in a complicated situation. In an endemic area or in an immunocompromised individual, a higher index of suspicion would allow early recognition and treatment institution to minimise its late consequences as well as spreading of the disease. Though anti-TB is the mainstay of treatment, surgical intervention might be needed in selected cases.
    MeSH terms: Uterine Cervical Diseases; Developing Countries; Female; Health Facilities; Humans; Prolapse; Tuberculosis; Tuberculosis, Urogenital
  13. Sreetharan SS, Philip R
    Case Rep Otolaryngol, 2012;2012:367349.
    PMID: 23320231 DOI: 10.1155/2012/367349
    This case report highlights an unusual case where a foreign body in the parotid gland was initially thought to be sialolithiasis based on CT scans. The foreign body was safely retrieved from the parotid gland without formal superficial parotidectomy using methylene blue and an image intensifier to localize the lesion. Diagnosis and management of foreign bodies in the parotid gland are reviewed, and surgical options in removal of such lesions are discussed.
  14. Baharudin A, Rohaida I, Khairudin A
    Acta Inform Med, 2012 Jun;20(2):133-5.
    PMID: 23322967 DOI: 10.5455/aim.2012.20.133-135
    Eagle's syndrome represents a symptomatic styloid process elongation or calcification of stylohyoid or stylomandibular ligament. The symptoms include the throat pain radiating to ipsilateral ear or foreign body sensation in the pharynx causing odynophagia and dysphagia. It is commonly unilateral and bilateral cases are rare. We report a case of bilateral elongation of styloid processes treated surgically by transoral approach.
    MeSH terms: Calcification, Physiologic; Calcinosis; Deglutition Disorders; Foreign Bodies; Ligaments; Ossification, Heterotopic; Pain; Pharynx; Sensation; Temporal Bone
  15. Balasubramanian A, Abdullah B
    Acta Inform Med, 2012 Sep;20(3):192-3.
    PMID: 23322978 DOI: 10.5455/aim.2012.20.192-193
    Respiratory distress is one of the commonest cause of admission into a Neonatal Intensive Care Unit, be it surgical or medical in nature. Adequate and prompt resuscitation as well as intubation can be life saving. Emergency or early tracheostomy may be necessary if airway intervention is needed. The authors present the case of a term neonate who was born with a large cervical cystic hygroma causing compression of the airway, together with a concurrent grade III subglottic stenosis, in respiratory distress within few minutes of life. Nine months post tracheostomy and sclero-therapy treatment twice, the child shows marked improvement. The succesful management of this unusual case of severe extrinsic compression with concurrent internal airway obstruction is presented.
  16. Basir R, Rahiman SF, Hasballah K, Chong W, Talib H, Yam M, et al.
    Iran J Parasitol, 2012;7(4):62-74.
    PMID: 23323093
    Animal models with various combination of host-parasite have long been employed to study malaria pathogenesis. Here, we describe the combination of Plasmodium berghei ANKA infection in inbred ICR mice as a model of cerebral malaria (CM).
  17. Tan BB, Chan CY, Saw LB, Kwan MK
    Indian J Orthop, 2012 Nov;46(6):710-3.
    PMID: 23325978 DOI: 10.4103/0019-5413.104235
    Unstable spine fractures commonly occur in the setting of a polytraumatized patient. The aim of management is to balance the need for early operative stabilization and prevent additional trauma due to the surgery. Recent published literature has demonstrated the benefits of early stabilization of an unstable spine fracture particularly in patients with higher injury severity score (ISS). We report two cases of polytrauma with unstable spine fractures stabilized with a minimally invasive percutaneous pedicle screw instrumentation system as a form of damage control surgery. The patients had good recovery from the polytrauma injuries. These two cases illustrate the role of minimally invasive stabilization, its limitations and technical pitfalls in the management of unstable spine fractures in the polytrauma setting as a form of damage control surgery.
    MeSH terms: Humans; Multiple Trauma; Spine; Injury Severity Score; Spinal Fractures; Fractures, Bone; Pedicle Screws
  18. Nishiki I, Minami T, Chen SC, Itami T, Yoshida T
    J Gen Appl Microbiol, 2012;58(6):457-63.
    PMID: 23337581
    Group C Streptococcus dysgalactiae (GCSD) is a pathogen of farmed fish. Almost all GCSD isolates from Asian countries, including Japan, Taiwan, Malaysia, and China, have a serum opacity factor (SOF-FD). Although the SOF-FD sequences in different GCSD isolates are identical, different opacification activities are observed. Three types of variations were observed in the upstream sequence of the sof-FD gene in GCSD isolates with different SOF-FD activities. Type 1 was characterized by insertion of an IS981-like element into the upstream region of the sof-FD gene. In Type 2, an IS981-like element was inserted into the upstream region in a direction opposite to that in Type 1. In Type 3, no IS element was inserted. Type 1 was predominant among Japanese isolates (129 of 133). Isolates from other Asian countries were generally Type 3 (13 of 16). Except for 1 strain, Type 1 strains exhibited opacification activities with optical densities (ODs)>0.6, while Type 2 and Type 3 strains have low opacification activities (ODs >0.2). Only Type 1 strains have putative -10 and -35 promoter regions upstream of the sof-FD gene, and the expression level of the sof-FD gene was higher in Type 1 strains than in Type 2 and Type 3 strains.
    MeSH terms: Animals; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Bacterial Proteins/chemistry; China; DNA Transposable Elements; Fish Diseases/microbiology*; Genotype; Japan; Malaysia; Peptide Hydrolases/genetics; Peptide Hydrolases/metabolism*; Peptide Hydrolases/chemistry; Perciformes/microbiology*; Phylogeny; Streptococcal Infections/microbiology; Streptococcal Infections/veterinary*; Streptococcus/classification*; Streptococcus/genetics; Streptococcus/isolation & purification*; Streptococcus/metabolism; Taiwan; Polymerase Chain Reaction/methods; Mutagenesis, Insertional; Sequence Analysis, DNA
  19. Shameli K, Ahmad MB, Zamanian A, Sangpour P, Shabanzadeh P, Abdollahi Y, et al.
    Int J Nanomedicine, 2012;7:5603-10.
    PMID: 23341739 DOI: 10.2147/IJN.S36786
    Green synthesis of noble metal nanoparticles is a vastly developing area of research. Metallic nanoparticles have received great attention from chemists, physicists, biologists, and engineers who wish to use them for the development of a new-generation of nanodevices. In this study, silver nanoparticles were biosynthesized from aqueous silver nitrate through a simple and eco-friendly route using Curcuma longa tuber-powder extracts, which acted as a reductant and stabilizer simultaneously. Characterizations of nanoparticles were done using different methods, which included ultraviolet-visible spectroscopy, powder X-ray diffraction, transmission electron microscopy, scanning electron microscopy, energy-dispersive X-ray fluorescence spectrometry, and Fourier-transform infrared spectroscopy. The ultraviolet-visible spectrum of the aqueous medium containing silver nanoparticles showed an absorption peak at around 415 nm. Transmission electron microscopy showed that mean diameter and standard deviation for the formation of silver nanoparticles was 6.30 ± 2.64 nm. Powder X-ray diffraction showed that the particles are crystalline in nature, with a face-centered cubic structure. The most needed outcome of this work will be the development of value-added products from C. longa for biomedical and nanotechnology-based industries.
    MeSH terms: Oxidation-Reduction; Particle Size; Plant Extracts/chemistry; Silver/chemistry*; Spectrophotometry, Ultraviolet; X-Ray Diffraction; Spectroscopy, Fourier Transform Infrared; Curcuma/chemistry*; Plant Tubers/chemistry; Microscopy, Electron, Transmission; Metal Nanoparticles/chemistry*; Green Chemistry Technology/methods*
External Links