Browse publications by year: 2012

  1. Cytotoxicity of triphenyltin(IV) methyl- and ethylisopropyldithiocarbamate compounds in chronic myelogenus leukemia cell line (K-562)
    Awang N, Kamaludin NF, Hamid A, Mokhtar NW, Rajab NF
    Pak J Biol Sci, 2012 Sep 01;15(17):833-8.
    PMID: 24163967
    Studies on the discovery of new cancer treatment by using metal-based compounds such as tin (Sn) has now greatly being synthesized and evaluated to identify their effectiveness and suitability to be developed as a new anticancer drug.

    APPROACH: This study was carried out to evaluate the cytotoxicity of triphenyltin(lV) methylisopropyldithiocarbamate (compound 1) and triphenyltin(IV) ethylisopropyldithiocarbamate (compound (2) on chronic myelogenus leukemia cells. The determination of their cytotoxicity (IC50) at different time of exposure and concentration was carried out through the employment of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) assay.

    RESULTS: The IC50 values obtained for compound 1 and 2 following treatment at 24, 48 and 72 h were 0.660, 0.223, 0.370 microM and 0.677, 0.306, 0.360 microM, respectively. Cell morphological changes such as apoptotic and necrotic features were also been observed.

    CONCLUSION: The compounds tested were found to give cytotoxic effect against chronic myelogenus leukemia (K-562) cell at a micromolar dose. Thus, further study on their specific mechanism of actions in the human cells should be carried out to elucidate their potential as an anticancer agent.

    MeSH terms: Antineoplastic Agents/pharmacology*; Cell Survival/drug effects; Dose-Response Relationship, Drug; Humans; Necrosis; Organotin Compounds/pharmacology*; Thiocarbamates/pharmacology*; Time Factors; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology*; Apoptosis/drug effects; K562 Cells; Inhibitory Concentration 50; Cell Shape/drug effects
  2. Commentary
    Zunaina E
    J Neurosci Rural Pract, 2012 May;3(2):226-7.
    PMID: 22865993
  3. Fulltext Evaluation of the proximate, fatty acid and mineral composition of representative green, brown and red seaweeds from the Persian Gulf of Iran as potential food and feed resources
    Rohani-Ghadikolaei K, Abdulalian E, Ng WK
    J Food Sci Technol, 2012 Dec;49(6):774-80.
    PMID: 24293698 DOI: 10.1007/s13197-010-0220-0
    The proximate, fatty acid and mineral composition were determined for green (Ulva lactuca and Enteromorpha intestinalis), brown (Sargassum ilicifolium and Colpomenia sinuosa) and red (Hypnea valentiae and Gracilaria corticata) seaweeds collected from the Persian Gulf of Iran. Results showed that the seaweeds were high in carbohydrate (31.8-59.1%, dry weight) and ash (12.4-29.9%) but low in lipid content (1.5-3.6%). The protein content of red or green seaweeds was significantly higher (p 
    MeSH terms: Phaeophyta; Rhodophyta; Carbohydrates; Fatty Acids; Fatty Acids, Unsaturated; Iran; Lipids; Minerals; Seaweed; Vegetables; Fatty Acids, Omega-3; Indian Ocean; Ulva; Sargassum; Gracilaria
  4. Fulltext Characterisation of the Virulence Factors and Genetic Types of Methicillin Susceptible Staphylococcus aureus from Patients and Healthy Individuals
    Lim KT, Hanifah YA, Yusof MY, Thong KL
    Indian J Microbiol, 2012 Dec;52(4):593-600.
    PMID: 24293716 DOI: 10.1007/s12088-012-0286-7
    Methicillin sensitive Staphylococcus aureus is an important bacterial pathogen associated with hospital- and community-acquired infections leading to endocarditis, skin tissue infection and pneumonia. The objective of this study was to determine both the genetic characteristics of methicillin-sensitive S. aureus (MSSA) strains, and the occurrence of virulence factors produced by S. aureus strains isolated from UMMC and healthy students in the University from year 2009. Out of 429 nasal swab samples, 67 were MSSA. The prevalence of 21 different virulence genes among 67 Malaysian clinical and community MSSA strains was determined by PCR, and their genetic features were assessed by PCR-RFLP of coa gene, agr types, spa typing and PFGE. The five predominant virulence genes were ica (79 %), efb and fnbA (61 % each), sdrE (57 %) and hlg (45 %). Toxin genes (enterotoxin, etd and pvl) were significantly more common (P 
  5. Fulltext Rare case of temporal bone carcinoma with intracranial extension
    Kasim KS, Abdullah AB
    Indian J Otolaryngol Head Neck Surg, 2012 Dec;64(4):397-8.
    PMID: 24294589 DOI: 10.1007/s12070-011-0250-6
    Temporal bone cancer, a relatively rare disease, accounting for less than 0.2% of all tumors of the head and neck and is associated with a poor outcome; often presents in a subtle manner, which may delay diagnosis. It should be suspected in any case of persistent otitis media or otitis externa that fails to improve with adequate treatment. Despite advances in operative technique and postoperative care, long-term survival remains poor). It includes cancers arising from pinna that spreads to the temporal bone, primary tumors of the external auditory canal (EAC), middle ear, mastoid, petrous apex, and metastatic lesions to the temporal bone. Here is a report on a case of temporal bone carcinoma presenting with right otalgia, otorrhea and facial paralysis. The patient was initially diagnosed as mastoiditis and later the clinical impression was revised to temporal bone carcinoma (undifferentiated type), based on the pathologic findings.
    MeSH terms: Ear Canal; Ear, Middle; Earache; Facial Paralysis; Humans; Long-Term Care; Mastoid; Mastoiditis; Neoplasms; Otitis Externa; Otitis Media; Temporal Bone; Rare Diseases
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