Kenaf fibre is one of the natural fibers that has received much attention of many researchers because of its good properties and flexible use. Kenaf fibre composites have been proposed as interior building materials. In this study, the recycling effect on the kenaf PVC wall panel is focused. The main objective of this study is to determine the mechanical properties of different types of kenaf PVC wall panels. The samples were formulated based on the first and third recycling process. The specimens were subjected to several types of tests, namely, tensile, izod impact, flexural and hardness based on ASTM D3039, ASTM D256, ASTM D7264 and ASTM D785, respectively. The results indicate that the mechanical properties of the third recycled kenaf PVC wall panel product is better than the virgin and first recycled specimen. This shows that the recycling process enhances the mechanical properties of the product. On the other hand, the hardness of the specimen decreases after first recycling due to the reheating effect.
Cryopreservation by vitrification has been widely used in Assisted Reproductive Technology (ART) to preserve embryos for an extended period of time. However, the effect of vitrification on development of the embryos is lacking. Therefore, understanding on vitrification effects on embryonic proteins, especially those involved in preimplantation development is crucial to provide high quality embryos for further usage. In this study, XIAP and S6K1 protein expressions following vitrification was investigated, since they have been implicated in diverse cellular processes including cell growth, migration, proliferation, differentiation, survival and development of preimplantation embryos via the PI3K pathway. Embryos were obtained from superovulated female ICR mice which were mated with fertile males. The embryos were harvested at the 2-cell stage and cultured until blastocyst stage. Blastocysts were then vitrified in ESF40 cryoprotectant. Western blot was carried out to determine the expression of XIAP and S6K1 proteins. The results showed the expression of XIAP and S6K1 significantly decreased in vitrified blastocyst compared to the control. This indicates that blastocyst vitrification may impact developmental competence through the activation of apoptotic pathways.
This study was conducted to investigate mitochondrial, nuclear chromatin and cytoskeletal organisation of vitrified embryos based on timing of the first zygotic cleavage. Embryos were retrieved from superovulated ICR mice, 28 hours after hCG injection. Two-cell stage embryos were categorised as earlycleaving (EC), while zygotes with 2-pronuclei as late-cleaving (LC) embryos. Embryos were cultured overnight in M16 medium supplemented with 3% bovine serum albumin (BSA) in carbon dioxide incubator. After 20 hours, the embryos were vitrified for one hour and warmed to room temperature. They were then fixed and immunostained to visualise distribution and intensity of mitochondria, nuclear chromatin and cytoskeleton. Finally, the embryos were mounted on glass slides and examined under a Confocal Laser Scanning Microscope (CLSM). Fluorescence intensities were analysed using LAS-AF-Lite Software. Results showed that EC embryos had significantly higher mitochondria (39.22 ± 12.50 versus 35.42 ± 14.61 pixel, p
The purpose of this study was to develop a simple, economical but efficient procedure to collect illuminance data in quantifying interior lighting. This study was carried out in 3.8 m × 2.9 m × 3.0 m controlled experimental room. Three approaches to measure illuminance level were examined: (1) rowto-row; (2) column-to-column; and (3) zig-zag direction. A pre-determined 34 measurement points was used for all the three approaches. The duration required to complete the illuminance data measurement was recorded in minutes. There was a statistically significant difference in the total time measured to complete the illuminance data measurement in three different approaches (F(2, 4) = 23266.81, p
This article aims to quantify the colour discrimination ability by using Total error scores (TES) to categorise colour discrimination level into superior, average or inferior levels under three different types of light sources, with different spectral power distribution. Colour discrimination was investigated using Farnsworth-Munsell 100 hues and compared upon three light sources: compact fluorescent light (CFL), fluorescent light (FL) and light emitting diode (LED). Total error score calculated and pattern of colour caps misplacement plotted used the web-based scoring method (http://www.torok.info/colorvision/fm100. htm). Total error score (TES) for three types of light sources (TES for LED 58.00 ± 18.67, FL 80.00 ± 19.27 and CFL 127.25 ± 28.02) were significantly different [One-way ANOVA (F=9.98, P
A full description of a new reading chart in Malay language, the Buari-Chen Malay Reading Chart (BCMRC) is described. Internal and external comparisons of BCMRC are also reported. BCMRC comprised four reading sets with contextual sentence (CS1 and CS2) and random words (RW1 and RW2) designs. A total of 14 prints, ranging from 1.3LogMAR to 0.0LogMAR in 0.1LogMAR steps (equivalent to 8 M to 0.4 M) were printed in high contrast Arial font. CS1, CS2, RW1 and RW2 were presented in random order to the participants for internal comparison. The reading was evaluated aloud with clear pronunciation (errors were recorded). Maximum reading speed (MRS) was reported in words per minute. The external comparison involved two standard English reading charts [MNread acuity chart (MNread) and Bailey-Lovie words reading chart (Bailey-Lovie)]. The internal and external comparisons were analysed using the intra-class correlation coefficient (ICC) and Cronbach’s alpha (α) respectively. Contextual sentence set (ICC=0.82) and random word set (ICC=0.85) exhibited good reliability in our internal comparison. The external comparison showed acceptable reliability for both MNread (α=0.76) and Bailey-Lovie (α=0.80). BCMRC sets with similar features could be used interchangeably to monitor clinical progress in visual rehabilitation. BCMRC was comparable with MNread and Bailey-Lovie reading charts.
High uncertainties in aerosol radiative forcing (ARF) arise from inaccurate estimation for aerosol optical depth (AOD) as an input parameter into Santa Barbara Discrete Ordinate Radiative Transfer (SBDART) model. Influence of AOD in ARF at the top of atmosphere (TOA) and surface over Kuching from 2011 until 2015 was investigated using Moderate Resolution Imaging Spectroradiometer (MODIS). Multi plane regression technique was used to retrieve AOD from MODIS (AODMODIS) by using different statistics (mean and standard deviation (MODISµ±σ) and relative absolute error (MODISRAE) for accuracy assessment in spatial averaging and compared with Aerosol Robotic Network (AERONET). The relationship between AODMODIS and AOD from AERONET (AODAERONET) showed R2 value for MODISµ±σ and MODISRAE is 0.906 and 0.932, respectively. AODMODIS over Kuching tends to underestimate AOD during low variations and overestimate AOD when aerosol loading is higher. The retrieval of AODMODIS was used as an input parameter into SBDART for ARF estimation and compared with ARF from AERONET. When using AODMODIS from MODISµ±σ, the ARF at TOA was between -5.95 Wm-2 and 0.89 Wm-2 and at the surface was from -389.7 Wm-2 and -31.4 Wm-2 while for MODISRAE, ARF value at the surface was from -392.3 Wm-2 and -27.3 Wm-2 while at TOA was between -5.89 Wm-2 and 0.98 Wm-2. Average ARF value within the atmosphere for both MODISµ±σ and MODISRAE were 151.6 Wm-2 and 130.4 Wm-2, respectively. There is a poor relationship between the SBDART and AERONET for MODISµ±σ, where R2 is 0.33, while strong relationship is observed for MODISRAE with R2 value at 0.724.
Post Weld Impact Treatment (PWIT) is necessary in order to improve the tensile shear and hardness strengths on the welded joints of spot welding process. PWIT can be performed via Low Blow Impact Treatment (LBIT), which is the main focus in this research. In this present study, two plates of low carbon steel (LCS) with dimensions of 110 mm × 45 mm × 1.2 mm underwent a resistance spot welding. All welded samples were later tested for their mechanical properties by performing the tensile-shear, hardness test and qualitative analysis. Tensile shear test was conducted on the spot welded area for both treated and untreated samples using crosshead speed of 2 mm/min, while hardness test was performed using 1 kgf load Vickers hardness indenter. The effects of LBIT on tensile-shear properties, hardness and fatigue strength were evaluated and it was found that the implementation of LBIT increased the tensile shear strength, fatigue strength and hardness on the welded joint significantly.
This study focuses on examining the influence of post weld impact treatment (PWIT) using Pneumatic Impact Treatment (PIT) for spot welded joint on mechanical properties and fatigue failure. PWIT is one of the methods for improving mechanical properties and fatigue strength of welded joints. One of the versatile techniques of PWIT used for this study is PIT. The material investigated in this study was carbon steel with welded single lap shear joint with the constant thickness of 1.2mm. All the welded samples were later performing the tensile shear test, hardness test, and fatigue test. The tensile shear test was conducted on the spot welded both treated and untreated samples using crosshead speed of 2 mm/ min, while hardness test was performed using 1kgf load via Vickers hardness indenter. Fatigue test was conducted using R=0.1 and frequency of 10 Hz. The effects of PIT on tensile-shear properties, hardness, and fatigue failure were evaluated. It was found that the implementation of PIT has increased tensile shear and hardness significantly and prolonged lifetime of spot welded joint.
In this study, oil palm fruit bunch fiber (OPEFB) was used as a secondary filler in HDPE/clay nanocomposites. The composites were prepared by melt compounding, containing high density polyethylene (HDPE), OPEFB fibers, Maleic anhydride grafted polyethylene (MAPE) and four different clay loading (3, 5, 7 and 10 PE nanoclay masterbatch pellets per hundred HDPE pellets). Four OPEFB sizes (180 μm, 250 μm, 300 μm and 355 μm) were added in the composites to investigate its effects on the fracture toughness and impact strength. Fracture toughness of the composites was determined according to ASTM D5045 and single edge notch bending (SENB) was employed during the test while impact tests were performed according to ASTM D256. The effects of alkali treatment were also investigated in this study. The result indicates that the fracture toughness slightly increased as clay loading increased. The highest value of fracture toughness was 0.47 and 1.06 MPa.m1/2 at 5 phr for both types of composites. The presence of OPEFB fiber as a secondary filler in the matrix indicates significant enhancement of fracture toughness up to 133%. However, its impact strength seems to deteriorate with the presence of OPEFB fiber.
Objective: We aimed to assess the impact of Nottingham grade (NG) on breast cancer specific survival (BCSS) and recurrence free survival (RFS) of operable breast cancer (BC) patients presenting at different TNM stages in view of assessing the value of NG in prognostication of breast cancer in the Sri Lankan setting. Method: This retro-prospective study included a consecutive series of TNM stage I to III BC patients presented to our unit from 2006 to 2012. Data were collected through follow up visits, clinic and laboratory records. Grading and scoring of oestrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor 2 (Her2) expressions were done by a single investigator. Kaplan-Meier and Cox-regression models were used in the survival analysis. Results: A total of 742 (NG1-12%; NG2-45%; NG3-43%) patients with a median follow up of 39.5 (range: 12 - 138) months were included. Five-year BCSS was 94%-NG1, 80%-NG2 and 72%-NG3 (p < 0.001). Five-year RFS was 86%-NG1, 75%-NG2 and 67%-NG3 (p = 0.001). Only the lymph-node status (LNS) (p = 0.001) had an independent effect on the BCSS and RFS of NG3 patients. LNS (p = 0.001), PR (p = 0.004) and Her2 (p < 0.001) independently affected the BCSS of NG2 patients. None of the factors considered had an effect on the BCSS/RFS of NG1 patients. A significant decrease in BCSS and RFS was seen with an increase in NG in the sub-group of TNM stage III (p = 0.01 and 0.011). Conclusion: NG categorizes BC patients into prognostic groups with distinctly different survival outcomes. Sub-categorization of TNM stage III by NG is suggested.
Introduction of high-sensitivity cardiac troponin I (hscTn I) assays for routine clinical use in
Malaysia requires determination of the 99th percentile upper reference limit (URL) for each assay to
suit local context. Hence, this study aimed to determine the 99th percentile URL for hscTn I in the
Malaysian population. A total of 250 (120 males and 130 females) healthy Malaysian blood donors
aged 18 to 60 years old were recruited. Blood samples for hscTn I were measured using Abbott
Diagnostics hscTn I assay on Architect i2000sr analyser. The 99th percentile was calculated using
a non-parametric method and gender specific results were compared. The 99th percentile URL for
hscTn I for the overall population was 23.7 ng/L, with gender specific values being 29.9 ng/L and
18.6 ng/L for male and female, respectively. Females had significantly lower hscTn I compared to
males. This study confirms the use of gender specific 99th percentile URL for hscTn I for clinical
use in a multi-ethnic Malaysian population.
Tocotrienols have been reported to possess potent cholesterol lowering, anti-hypertensive, antiinflammatory and anti-oxidative properties which are superior to tocopherols. Emerging evidence suggests pure tocotrienols have anti-atherogenic properties. However, optimal doses of oftocotrienolrich fraction (TRF) in progressive atherogenesis remain unclear. This animal model experiment was designed to investigate the effects of a range concentration of TRF supplementation on the extent of atherosclerosis and soluble lipids, inflammatory and oxidative stress biomarkers in high-cholesterol diet (HCD) induced hypercholesterolaemic (HC) rabbits with atherosclerosis. A total of 28 New Zealand white rabbits were given 1% high-cholesterol diet (HCD) for two months and then randomised into five groups: Placebo (n=7), TRF 15 mg/kg (n=5), TRF 30 mg/kg (n=6), TRF 60 mg/kg (n=5) and TRF 90 mg/kg (n=5) daily. The treatment was given for three months and the animals were fed HCD throughout the duration. Aortic vessels were obtained to assess the extent of atherosclerotic lesions at the end of the study. Fasting serum lipids (FSL), C-reactive protein (CRP), malondialdehyde (MDA) and 8-isoprostane levels were measured at baseline, one and two months post-HCD, one, two, and three months postintervention. There were no differences in the extent of the atherosclerotic lesions, percentage changes of FSL, MDA, 8-isoprostane and CRP levels between the placebo and TRF groups. In conclusion, TRF across all doses studied have neutral effects on atherosclerotic lesions, soluble lipids, biomarkers of oxidative stress, coronary risk and inflammation in severely atherosclerotic rabbits with progressive and continuous insult by high cholesterol feeding.
Chronic inflammation plays a pivotal role in atherogenesis. Antioxidants have a potential role in the prevention and treatment of atherosclerosis. The effects of palm oil-derived tocotrienol-rich fraction (TRF) supplementation on inflammation are not well established. This study aims to investigate the effects of TRF supplementation on the inflammatory biomarkers and adhesion molecules in severe atherosclerosis. A total of 28 New Zealand white rabbits were given 1% high-cholesterol diet (HCD) for five months and randomised from the second month onwards into one of five intervention groups: Placebo, TRF 15, 30, 60 and 90 mg/kg/day. Treatment was given for three months and the animals were fed HCD throughout the duration. At the end of the study, the aortas were obtained, stained with Sudan IV, fixed in formalin, embedded in paraffin and immunostained for tissue intracellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), E-selectin, smooth muscle actin (SMA), and nuclear factor-κB (NF-κB). The amount of atherosclerotic lesions was not significantly different between the groups and compared to placebo. Qualitative analysis showed lower trend of ICAM-1, IL-6, E-selectin and NF-κB but higher trend of SMA tissue expression in TRF-treated groups especially at low dose of TRF (TRF-15) compared to placebo. Quantitative analysis showed lower ICAM-1 and E-select in positivity in TRF-15 compared to placebo group (25.1 ± 7.4 % vs. 3.8 ± 2.0 %, 23.2 ±6.5 % vs. 4.2± 2.1 %, respectively, p
Oxidation of low-density lipoprotein (LDL) and activation of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) are critical for the inflammatory response for endothelial dysfunction. The objective of this study is to investigate the effects of various doses of HDL on: (a) LDL susceptibility to oxidation; (b) expression of eNOS; and (c) expression of NF-κB p50 and p65. Different concentrations of HDL were incubated in LDL. The reaction rates of LDL susceptibility to oxidation were obtained by kinetic modeling analysis. For determination of eNOS, NF-κB p50 and p65 expression, different HDL concentrations were incubated in lipo polysacharides (LPS)-stimulated human umbilical vein endothelial cell line for 16 hours. Protein was extracted and analysed by western blot and nuclear transcription factor, for example, Co-incubation of LDL with increasing HDL concentrations showed longer lag time and lower reaction rate in a dose-dependent manner compared to controls (p
Objective: Mental health is often stigmatized in Asia, and electroconvulsive therapy (ECT) is portrayed negatively in the media. The objective of this short report is to obtain an insight on Asian countries’ perception on Electroconvulsive Therapy, mainly through the media.
Methods: Several online movie databases were searched, with emphasis on Asian movies’ portrayal of Electroconvulsive Therapy.
Results: Electroconvulsive Therapy (ECT) was portrayed in 9 television programme, 4 in films and 2 on Youtube. All patients (15) had no proper information given on possible side effects and consent not taken in all of them. 5 patients (33%) were tortured via ECT, 3(20%) of them had, ECT for Schizophrenia. In all scenes (15/15, 100%) ECT were given without general anaesthesia and the patients were fully awake. Basic monitoring (2/15, 13%) was performed, and all patients had no oxygenation. Tonic Clonic seizures were visible because all patients received no muscle relaxant. Bilateral electrode's placements (13/15, 87%) were common. One (6.6%) patient had a trilateral electrode placement. Most patients (9/15, 60%) received one shock, 4 patients (27%) received 2 shocks. One patient (6.6%) received 3 and 1 patient (6.6%) 4 shocks. 100% of patients were in obvious discomfort and ECT was portrayed as barbaric. There was no death depicted post ECT.
Conclusion: ECT is under portrayed in the Asian media. Only the Indian and Pakistani medium broached the subject. In the majority of the scenes, ECT was portrayed
negatively. This shows a total lack of knowledge of ECT among the Asian population. Alarmingly, ECT was used as a torture device in 5 mediums. This only adds to the stigma of ECT in Asia. More needs to be done to correct the misconceptions of ECT in Asia.
MeSH terms: Electroconvulsive Therapy*; Mass Media
Objective: ADHD is a complex neurobiological disorder, which required tactful
intervention. Besides pharmacotherapy, there is still limited information in
addressing the efficacy of cognitive behavior therapy (CBT) for treating this
developmental disorder.
Methods: We report a case of late diagnosed of ADHD
whose facing difficulty to cope with her undergraduate degree. She has to repeat
her semester examination due to lack of attention. Denial was seen in both
patient and family in accepting the diagnoses, and posed roadblock for
successful intervention.
Results: Six sessions of CBT were conducted, coupled
with psycho education for both the family and patient. Consultation from the
university’s management helped her to accept and cope with her ADHD
symptoms, i.e. attention and impulsivity. The patient showed improvement
following this intensive bio-psycho-social intervention.
Conclusion: The short
duration of CBT was found suitable to be adapted and implemented in young
adult ADHD.
Objective: This case report highlights a case of young male referred for psychiatric evaluation due to paraphilic disorder. This 27-year old single male working as an assistant accountant was noted to have voyeuristic behaviour and presented with depressive symptoms since his teenage age. He has poor coping whenever he experiences stress in life. He started to watch pornographic videos and subsequently get involved by peeping pre-pubescent’s undergarments. These activities are followed by a compulsive behaviour such as masturbation to gratify his sexual arousal.
Results: The patient undergone several psychotherapy sessions, and medical report was furnished for the court's purpose. Our assessment revealed that he was suffering from a lifetime major depressive disorder,and he was prescribed with Tablet Sertraline 50mg/daily.He also has premature ejaculation, severe in nature. He regretted his voyeuristic urge and psychotherapyfocused on how to channel his sexual needs.
Conclusion: Mood disorder is seen in paraphilic disorder and has to be dealt with in order to establish good management care.
Objective: Sexual problems are common among patients who are on antidepressants treatment. The objective of this study is to determine the prevalence of PE and ED, and their potential risk factors that may impair their sexual function in a TH
Methods: A cross-sectional study using simple random sampling was conducted among adult male patients who are on antidepressant treatment in the TH psychiatric outpatient clinic. Respondents’ sociodemographic data were obtained. Participants were interviewed using a structured self-report questionnaire with 15-item International Index of Erectile Function (IIEF-15)where the scores lesser than 25 were indicative for having an ED. A validated Malay Premature Ejaculation Diagnostic Tool (MAPET) was used to assess PE and those with a score ≥ 23 were considered to have PE.
Results: Hundred respondents were participated, and the prevalence of PE and ED was 66% and 85%, respectively. Using multivariate binary logistic regression, the potential risk factors of PE were race, i.e. being non-Malay (p=0.044), lesser in the frequency of sexual activity (p=0.03) and also an ED (p=0.03), respectively. The only risk factor for ED was PE (p=0.026). No significant association was noted for the other factors, including type of the antidepressant, dose and duration of antidepressant used (p>0.05). There was a strong correlation of MAPET and IIEF-15 (r=-0.345, p < 0.01) signifying patient with more severe PE had more severe ED.
Conclusions: Due to very high rate of ED and PE in this group of respondents, it is pivotal to screen for sexual problem among patients who are taking an antidepressant in a psychiatric setup.
Study site: Psychiatric clinic, Pusat Perubatan University Kebangsaan Malaysia (PPUKM), Kuala Lumpur, Malaysia.
Objectives: This study investigated the relationship between coping skills and
psychosocial adjustments among parents of children with LD.
Method: A
cross-sectional study with a convenience sampling method was applied to a total
of 87 parents of children with LD from four non-government community
rehabilitation centers. They were measured using a validated Malay version of
the Family Crisis Oriented Personal Evaluation Scale (F-COPES) for coping
skills. The Modified Psychosocial Adjustment to Illness Scale-Self-Report
(PAIS-SR) was used to measure parents’ psychosocial adjustments.
Results: A
Spearman’s rho showed a correlation between total coping skills and
psychosocial adjustments scores among parents (rs= -0.43, p