Browse publications by year: 2020

  1. Abbasi, G. A., Yow, B. C., Goh, Y. N
    MyJurnal
    In the present work, the extended Theory of Planned Behaviour was utilised in order to exam- ine and unearth the consumer milk powder purchase intention after the milk powder scare. For this reason, a self-administered questionnaire was developed using established scales. Moreo- ver, a survey on 200 respondents was conducted in Penang, Malaysia through an online survey questionnaire. Statistical Package for the Social Science (SPSS) was utilised to analyse the data. The findings revealed that product knowledge, product involvement, and perceived benefit were positively and significantly related to purchase intention. Surprisingly, perceived risk and country of origin's image do not have any significant relationship with purchase inten- tion. Attitude, playing the role of the mediating variable in the present work, was discovered to have a mediating effect on the relationships among product knowledge, product involve- ment, perceived benefit, perceived risk, country of origin's image, and purchase intention regarding milk powder. The present work shines a new light on Malaysian consumers’ purchase intention towards milk powder. Furthermore, the results of the present work can be adopted as a source of reference by milk powder companies in order to formulate strategic marketing plans, for instance during the food scare crisis.
    MeSH terms: Animals; Attitude; Consumer Behavior; Malaysia; Milk; Powders; Surveys and Questionnaires; Social Sciences; Intention; Marketing
  2. Ng, Y. V., Tengku Alina, T. I., Wan Rosli, W. I.
    MyJurnal
    The intake of dietary fibre (DF) has been proven to lower the risk of chronic diseases, leading to the increasing demand for fibre-enriched bakery product. Banana is one of the most consumed fruits that exhibits rich sources of DF and provides excellent nutritional health benefits. However, overripe banana is discarded due to its low quality and appearance. Thus, the present work was aimed to determine the properties of chocolate cookies formulated with overripe banana pulp powder (OBPP) as partial replacement (0, 6, 8, and 10%) for wheat flour. Nutritional composition, physical properties, and sensory acceptability of the cookies were analysed using AOAC methods, texture profile analyser, and 7-point hedonic scaling method, respectively. Results showed that increased incorporation of OBPP significantly increased the nutritional values of chocolate cookies. Chocolate cookies formulated with 10% of OBPP recorded the highest total dietary fibre (8.21%) and ash (1.23%) contents. In texture profile analysis, the firmness of the chocolate cookies was recorded to increase slightly with increasing level of OBPP, although this was not significant. Sensory scores for the control (0%) and 6% OBPP-incorporated cookies were not significantly different for all the sensory attributes. However, the incorporation of 8% OBPP produced the highest scores in terms of aroma, flavour, and overall acceptance. In summary, the addition of 8% OBPP could be an effective way to produce nutritious and the most palatable chocolate cookies.
    MeSH terms: Chronic Disease; Dietary Fiber; Flour; Fruit; Nutritive Value; Powders; Taste; Triticum; Musa; Chocolate
  3. Sallehuddin, N. A., Azizah Abdul Hamid, Salleh, S. Z., Nazia Abdul Majid, Hani Hafeeza Halim, Nurul Shazini Ramli, et al.
    MyJurnal
    In the present work, aqueous ethanolic (60% ethanol) extracts from selected Malaysian herbs
    including Murraya koenigii L. Spreng, Lawsonia inermis L., Cosmos caudatus Kunth, Piper
    betle L., and P. sarmentosum Roxb. were evaluated for their ergogenic, anti-diabetic and
    antioxidant potentials. Results showed that the analysed herbs had ergogenic property and
    were able to activate 5'AMP-activated protein kinase (AMPK) in a concentration dependant
    manner. The highest AMPK activation was exhibited by M. koenigii extract which showed no
    significant (p > 0.05) difference with green tea (positive control). For anti-diabetic potential,
    the highest α-glucosidase inhibition was exhibited by M. koenigii extract with IC50 of 43.35
    ± 7.5 µg/mL, which was higher than acarbose (positive control). The determinations of free
    radical scavenging activity and total phenolics content (TPC) indicated that the analysed herbs
    had good antioxidant activity. However, C. caudatus extract showed superior antioxidant
    activity with IC50 against free radical and TPC of 21.12 ± 3.20 µg/mL and 221.61 ± 7.49 mg
    GAE/g, respectively. RP-HPLC analysis established the presence of flavonoids in the herbs
    wherein L. inermis contained the highest flavonoid (catechin, epicatechin, naringin and rutin)
    content (668.87 mg/kg of extract). Correlations between the analyses were conducted, and
    revealed incoherent trends. Overall, M. koenigii was noted to be the most potent herb for
    enhancement of AMPK activity and α-glucosidase inhibition but exhibited moderate antioxidant activity. These results revealed that the selected herbs could be potential sources of
    natural ergogenic and anti-diabetic/antioxidant agents due to their rich profile of phenolics.
    Further analysis in vivo should be carried out to further elucidate the mechanism of actions of
    these herbs as ergogenic aids and anti-diabetic/antioxidant agents.
    MeSH terms: Ethanol; alpha-Glucosidases; Antioxidants; Catechin; Chromatography, High Pressure Liquid; Flavonoids; Free Radicals; Plant Extracts; Rutin; Tea; Inhibitory Concentration 50; Acarbose; Lawsonia Plant; Piper; Murraya; AMP-Activated Protein Kinases; Glycoside Hydrolase Inhibitors
  4. Akbar, I., Jaswir, I., Jamal, P.
    MyJurnal
    Gelatine obtained from fish skin has become a potential source of preparing nanoparticles and
    encapsulation of bioactive compounds. Within these fish skin, gelatine nanoparticles show
    potent benefits for application in pharmaceutical and cosmetic industry. The encapsulated
    bioactive ingredients within nanoparticles have improved bioavailability, delivery properties,
    and solubility of the nutraceuticals within the human body and blood stream. Many of such
    bioactive peptides (biopeptides) are potent antioxidants; and as oxidative stress is the main
    cause of the onset of various chronic diseases, encapsulation of antioxidant biopeptides within
    fish gelatine nanoparticles could be a potential remedy to prevent or delay the onset of such
    diseases and for better health prospects. The purpose of the present work was to prepare a
    simple, safe, and reproducible novel food delivery nanoparticle system encapsulating a desirable antioxidant biopeptide. An optimisation study was conducted to produce a desirable size
    of gelatine nanoparticles which showed a higher encapsulation efficiency of an antioxidant
    biopeptide. Sunflower biopeptide was chosen as the antioxidant biopeptide, as the activity of
    this protein hydrolysate is quite high at DPPH of 89% and FRAP assay of 968 µm/L. Tilapia
    fish was used as gelatine source at an average yield of the process at 10% wt/wt. Effects of
    parameters such as pH, biopeptide concentration, and cross-linking agent ‘glutaraldehyde’ on
    the size, stability, and encapsulation efficiency on the nanoparticles were studied. The average
    diameter of the biopeptide loaded gelatine nanoparticle was between 228.3 and 1,305 nm.
    Encapsulation efficiency was 76% at an optimal pH of 2, glutaraldehyde concentration of 2
    mL, and biopeptide concentration of 0.1 mg/mL exhibited DPPH at 92% and FRAP assay of
    978 µm/L. To understand the absorption of sunflower biopeptide in stomach, blood stream,
    and biopeptide release of the gelatine nanoparticles, biopeptide loaded gelatine nanoparticles
    were subjected to simulated gastrointestinal conditions mimicking human stomach and
    intestine; and showed peptide release of 0.1464 and 0.277 mg/mL upon pepsin and pancreatin
    digestion, respectively.
    MeSH terms: Animals; Antioxidants; Biological Availability; Chronic Disease; Digestion; Pharmaceutical Preparations; Gelatin; Glutaral; Helianthus; Humans; Hydrogen-Ion Concentration; Intestines; Pancreatin; Pepsin A; Peptides; Protein Hydrolysates; Solubility; Stomach; Tilapia; Oxidative Stress; Human Body; Dietary Supplements; Nanoparticles
  5. Abdelkader Hassani, Siti Aslina Hussain?, Abdullah, N., Suryani Kamarudin, Rozita Rosli
    MyJurnal
    The present work investigated the antioxidant properties and antihypertensive activity of
    magnesium orotate (MgOr) using various established in vitro assays, such as β-carotene
    bleaching activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and nitric oxide scavenging activity as well as angiotensin converting enzyme (ACE) inhibitory activity. Magnesium orotate
    nanoparticles (MgOrGANPs) were prepared using the gum arabic (GA) as stabiliser coatings
    for nanoparticles through freeze-drying method. The in vitro cytoxicity of MgOrGANPs
    against human breast cancer MCF7, liver cancer HepG2, and colon cancer HT29 was investigated. The nitric oxide (NO) and DPPH scavenging assays of MgOrGANPs showed a
    dose-dependent trend, while 500 and 200 µL/mL were significantly more effective than the
    other concentrations with an IC50 of 89.56 µg/mL and 63.22% DPPH scavenging capacity
    respectively. The exposure of human cancer cells to MgOrGANPs at 1.56 – 1,000 µg/mL
    using 3-)4,5-dimethylthiazol-2-yl(2,5-diphenyl tetrazolium bromide (MTT) inhibited the
    growth of cell lines examined in a dose-dependent manner. Hence, MgOrGANPs may have
    great potential to be applied for cancer treatments.
    MeSH terms: Antihypertensive Agents; Antioxidants; Biphenyl Compounds; Breast Neoplasms; Bromides; Cell Line; Colonic Neoplasms; Gum Arabic; Humans; Peptidyl-Dipeptidase A; Liver Neoplasms; Nitric Oxide; Orotic Acid; Picrates; beta Carotene; Inhibitory Concentration 50; Nanoparticles
  6. Rosnah Shamsudin, Zulkifli, N. A., ?Amanina Amani Kamarul Zaman?
    MyJurnal
    Blending or mixing two or more of fruit juices is able to improve the quality of juices as
    compared to single flavour. Pineapple and mango are among the popular tropical fruits in
    Malaysia. Despite the massive production of pineapple in Malaysia, utilisation of pineapple as
    a juice remains unpopular due to its exotic and strong flavour. Blending of pineapple with
    mango is believed to overcome this issue. Nevertheless, suitable blending ratios play important role in the end product quality. The present work aims to determine the physicochemical
    and nutritional quality of fresh blended pineapple-mango juice at different blending ratios for
    25 days of refrigerated storage (4 ± 2°C). Physicochemical (colour, pH, titratable acidity, and
    total soluble solid) and nutritional (vitamin C, total phenolic content, and total antioxidant
    content) properties of fresh pineapple-mango juice blends of ratio 80% pineapple with 20%
    mango (R80:20) and 50% pineapple with 50% mango (50:50) were determined throughout 25
    days of storage. Pineapple-mango juice blends at blending ratio of R80:20 exhibited better
    qualities in term of colour (lightness, chroma, hue, and browning index), chemical composition, and nutritional content.
    MeSH terms: Fruit and Vegetable Juices; Antioxidants; Ascorbic Acid; Color; Fruit; Hydrogen-Ion Concentration; Malaysia; Nutritive Value; Phenols; Taste; Vitamins; Mangifera; Ananas
  7. Farawahida Abdul Halim, Jinap Selamat, Nor Khaizura Mahmud @ Ab Rashid, Chin, C. K., Nik Iskandar Putra Samsudin, Norlia, M.
    MyJurnal
    The aims of the present work were to determine the prevalence of Aspergillus spp. and occurrence of aflatoxins (AFs) along the peanut sauce processing line from different peanut sauce
    companies in Malaysia, and to determine to which extent peanut sauce processing steps
    employed by the peanut sauce industries could efficiently reduce AFs in peanut sauce. Peanut
    and chili samples were collected at each processing step along the peanut sauce production
    from three peanut sauce companies which were different in companies’ profile. Peanut
    samples from Companies B (87.5%) and C (100%) were contaminated with AFs. Of these,
    12.5% (Company B) and 75% (Company C) samples exceeded the Malaysian regulatory limit.
    None of the samples from Company A was contaminated. The steps efficient in reducing AFs
    in peanut sauce identified in the present work were (i) safety monitoring of raw materials, (ii)
    sorting of raw materials, and (iii) heat treatment of raw materials.
    MeSH terms: Aflatoxins; Aspergillus; Food; Hot Temperature; Fabaceae; Malaysia; Arachis; Prevalence
  8. Teow YH, Ooi BS, Ahmad AL, Lim JK
    Membranes (Basel), 2020 Dec 24;11(1).
    PMID: 33374274 DOI: 10.3390/membranes11010016
    Natural organic matters (NOMs) have been found to be the major foulant in the application of ultrafiltration (UF) for treating surface water. Against this background, although hydrophilicity has been demonstrated to aid fouling mitigation, other parameters such as membrane surface morphology may contribute equally to improved fouling resistance. In this work, with humic acid solution as the model substance, the effects of titanium dioxides (TiO2) types (PC-20, P25, and X500) on membrane anti-fouling and defouling properties were comparatively analysed. The aims are (1) to determine the correlation between membrane surface morphology and membrane fouling and (2) to investigate the anti-fouling and UV-cleaning abilities of PVDF/TiO2 mixed-matrix membranes with different membrane topographies and surface energy conditions. The mixed-matrix membrane with P25 TiO2 exhibited the most significant UV-defouling ability, with a high irreversible flux recovery ratio (IFRR(UV)) of 16.56 after 6 h of UV irradiation, whereas that with X500 TiO2 exhibited both superior anti-fouling and defouling properties due to its smoother surface and its highly reactive surface layer.
    MeSH terms: Humic Substances; Polyvinyls; Titanium; Ultrafiltration; Water; Water Purification; Physical Phenomena; Hydrophobic and Hydrophilic Interactions
  9. Ismail Fitry Mohammad Rashedi, Safiullah Jauhar, Chong, ?Gun Hean, Nor Khaizura Mahmud @ Ab Rashid, Wan Zunairah Wan Ibadullah
    MyJurnal
    Supercritical carbon dioxide (SC-CO2 ) is a non-thermal technique implemented by food, pharmaceutical, and similar industries with the aim of inhibiting the microorganisms and apply effective sterilisation. Presently, limited number of studies has reported the application of SC-CO2 on fresh chicken meat. The present work therefore aimed to reveal the microbial and physicochemical quality of the SC-CO2 -treated fresh chicken meat. The fresh chicken meat was subjected to the SC-CO2 at 14 MPa and 45°C for 40 min and was stored at 4°C for 0, 3, and 7 days. The obtained results indicated that the treatment with SC-CO2 significantly decreased the total plate count and, yeast and mould count from log10 5.90 to 2.00 CFU/g and from log10 5.02 to 2.00 CFU/g at day 7 of storage, respectively. The values of pH, cooking loss, and water holding capacity were not affected by the treatment. The results revealed that the SC-CO2 -treated samples displayed harder texture, higher lightness and yellowness, and lower redness. In addition, lipid peroxidation of SC-CO2 and control samples resulted in values of 1.9 and 0.5 MDA/mg of meat at day 7 of storage time and did not significantly change in the rest of the evaluation days. In summary, the application of SC-CO2 was capable of enhancing the microbial quality and certain physicochemical attributes. However, alteration of certain parameters of SC-CO2 might enhance the overall meat quality.
    MeSH terms: Animals; Carbon Dioxide; Chickens; Color; Cooking; Pharmaceutical Preparations; Hydrogen-Ion Concentration; Meat; Saccharomyces cerevisiae; Sterilization; Water; Yeast, Dried; Lipid Peroxidation
  10. Azhari, N. A. M., Markom, M., Ismail, I., Anuar, N.
    MyJurnal
    Polygonum minus is a plant rich with bioactive components that contribute to food, pharmaceutical, and perfume industries. However, high moisture content in fresh plants will allow
    microbial activity that leads to the degradation of plant quality. This can be prevented by
    drying the fresh plants to preserve the characteristics of their bioactive components. The
    present work was conducted to determine the effect of different drying methods such as
    air-drying, oven-drying (40 and 60°C), and freeze-drying on essential oil (EO) yield and
    chemical compounds of P. minus roots. For comparison purposes, all samples were extracted
    by maceration with n-hexane at room temperature. Then, the samples were analysed and
    identified by using gas chromatography-mass spectrometry (GC-MS). The highest EO yield
    extract was obtained from freeze-drying (4.15 ± 0.5), followed by air-drying (3.79 ± 0.19). EO
    yield from oven-drying at 40 and 60°C was 3.4 ± 0.14 and 0.86 ± 0.04, respectively. Results
    showed that by increasing the drying temperature, the EO yield would decrease and cause a
    loss of major chemical compounds in the P. minus root. Air-drying was found to be the best
    method in preserving the presence of important chemical compound in P. minus roots such as
    β-caryophyllene (1.43%), pentadecane (4.34%), hexadecanoic acid (3.91%) and oleic acid
    (3.97%).
    MeSH terms: Alkanes; Desiccation; Pharmaceutical Preparations; Freeze Drying; Gas Chromatography-Mass Spectrometry; Oils, Volatile; Perfume; Plant Extracts; Sesquiterpenes; Temperature; Oleic Acid; Palmitic Acid; Polygonum
  11. Siti Zaharah, R., Noranizan, M., Son, R., Roselina, K., Yusof, N. L., Koh, P. C., et al.
    MyJurnal
    Pennywort (Centella asiatica) is a herbaceous vegetable commonly consumed raw as ‘ulam’ or salad. Consumption of raw leafy green vegetables is one of the pathogenic mechanisms that could cause foodborne outbreaks. The aim of the present work was therefore to investigate the effect of pulsed light (PL) treatment at fluences of 1.5, 4.2, 6.9, 9.6, and 12.3 J/cm² on the microbiological and physical quality of pennywort stored at 4 ± 1°C. Escherichia coli (E. coli) were inoculated onto the pennywort leaves before being exposed to PL and viewed using scanning electron microscopy (SEM). PL fluences of 6.9, 9.6, and 12.3 J/cm² significantly reduced the microbial count; however, the highest inactivation was obtained by using fluences of 9.6 and 12.3 J/cm². The color of pennywort was not significantly affected by PL treatment applied at lower fluences of 1.5, 4.2, and 6.9 J/cm²; however, at higher fluence, 9.6 and 12.3 J/cm², the color was affected. PL at 1.5, 4.2, 6.9, and 9.6 J/cm² was able to retain the texture appearance of the leaves. To conclude, PL at 6.9 J/cm² showed the best fluence to reduce total aerobic mesophilic count while retaining the physical properties of pennywort leaves and extend the shelf life to about four days. The inactivation of E. coli population was significantly higher at PL fluence of 6.9 J/cm². It was observed that PL caused the destruction to the surface of E. coli’s cell membrane. The reductions of samples inoculated with E. coli were better than those achieved in native microbiota. Furthermore, the present work also demonstrated that PL treatment was able to reduce the microbial count on pennywort leaves.
    MeSH terms: Cell Membrane; Color; Disease Outbreaks; Escherichia coli; Microscopy, Electron, Scanning; Vegetables; Plant Leaves; Centella; Physical Phenomena; Microbiota
  12. Khalid SH, Liaqat I, Mallhi TH, Khan AH, Ahmad J, Khan YH
    J Pak Med Assoc, 2020 Dec;70(12(B)):2376-2382.
    PMID: 33475547 DOI: 10.47391/JPMA.370
    OBJECTIVE: Diabetes mellitus (DM) along with myocardial infarction (MI) carries increased burden on patients in terms of morbidity, mortality and cost. Current study was aimed to investigate the impact of DM on clinico-laboratory characteristics on in-hospital treatment outcomes among MI patients.o compare the outcome of mesh hernioplasty performed under local anaesthesia in relatively young and older patients regarding wound complications and urinary retention.

    METHODS: All MI patients admitted to the emergency department of Faisalabad Institute of Cardiology from April, 2016 to March, 2017 were recruited into the study. The clinico-laboratory profile and in-hospital outcomes of patients with and without DM were compared using chi-squared test or student t-test, where appropriate.

    RESULTS: A total 4063 patients (Mean age: 55.86 ± 12.37years) with male preponderance were included into the study. STEMI was most prevalent (n = 2723, 67%) type of MI among study participants. DM was present in substantial number of cases (n = 3688, 90.8%). Patients with DM presented with increased BMI, higher blood pressure, elevated levels of cholesterol, serum creatinine, and blood urea nitrogen, when compared to the patients without DM (p<0.05). Out of 560 patients who were followed up, cardiogenic shock was frequent (n = 293, 52.3%) adverse outcome followed by heart failure (n = 114, 20.4%), atrial fibrillation (n = 78, 13.9%) and stroke (n = 75, 13.4 %). Moreover, in-hospital adverse outcomes were more prevalent among MI patients with DM than those without DM.

    CONCLUSIONS: MI patients with DM present with varying clinico laboratory characteristics as well as experience higher prevalence of adverse cardiovascular events as compared to patients without DM. These patients require individual management strategy on very first day of admission.

    MeSH terms: Adult; Aged; Hospitals; Humans; Laboratories; Male; Middle Aged; Risk Factors; ST Elevation Myocardial Infarction*
  13. Mushtaq K, Ashraf M, Thaver IH
    J Pak Med Assoc, 2020 Dec;70(12(B)):2460-2463.
    PMID: 33475564 DOI: 10.47391/JPMA.770
    This descriptive cross-sectional research study was conducted to determine the characteristics of the women who intend to use a modern family planning method. For this 154 women were selected in a small village and faceto- face interviews were conducted. The findings indicate that 86 (56%) women intended to use a contraceptive method. The regression model showed that women who had the knowledge about different methods, those who had previously ever used family planning method and those who had never used any traditional method are more likely to adopt modern contraceptive methods.
    MeSH terms: Contraception*; Contraception Behavior; Cross-Sectional Studies; Family Planning Services*; Female; Humans; Health Knowledge, Attitudes, Practice; Knowledge
  14. Thaver I, Ahmad AM, Ashraf M, Asghar SK, Mirza MS
    J Pak Med Assoc, 2020 Dec;70(12(A)):2092-2101.
    PMID: 33475578 DOI: 10.47391/JPMA.1218
    OBJECTIVE: To investigate the effect on maternal and infant health of iron plus folate and multiple micronutrient supplements, along with deworming and health education session provided to pregnant women in rural, nonagrarian and food-insecure areas.

    METHODS: The quasi-experimental study was conducted in Tharparker and Umerkot districts, Sindh, Pakistan, in 2013-14, and comprised pregnant women in their earlier weeks of pregnancy. The enrolment and follow-up phase entailed 3 visits to each subject. Areas covered by lady health workers were designated as intervention areas, and those with non-LHW population were labelled as non-intervention areas.

    RESULTS: Of the 1204 subjects, 600(49.8%) were in the intervention group and 604(50.2%) were in the nonintervention group. By the end of the follow-up phase, significantly more women had increased number of meals in the intervention group compared to the non-intervention group (p<0.001). There was a significantly higher increase in mean haemoglobin levels and body mass index of women in the intervention arm after 3 and 6 months of interventions (p<0.05). Significantly higher mean birth weight was recorded in intervention areas compared to nonintervention areas (p<0.05).

    CONCLUSIONS: Community-based provision of multiple micronutrients to women along with deworming, health education and dietary counselling significantly reduced the prevalence of anaemia and reduced the incidence of low birth weight.

    MeSH terms: Birth Weight; Female; Humans; Infant; Infant, Low Birth Weight; Infant, Newborn; Pakistan/epidemiology; Pregnancy; Dietary Supplements; Pregnant Women*
  15. Azman Raffiq, Liew, Boon Seng, Lim, Swee San, Zaitun Zakaria, Ang, Song Yee, Fitzrol, Diana Noma, et al.
    MyJurnal
    The newly discovered coronavirus disease 2019 (COVID-19) is an infectious disease introduced to humans for the first time. Following the pandemic of COVID-19, there is a major shift of practices among surgical departments in response to an unprecedented surge in reducing the transmission of disease. With pooling and outsourcing of more health care workers to emergency rooms, public health care services and medical services, further in-hospital resources are prioritised to those in need. It is imperative to balance the requirements of caring for COVID-19 patients with imminent risk of delay to others who need care. As Malaysia now approaches the recovery phase following the pandemic, the crisis impacted significantly on neurosurgical services throughout the country. Various emergency measures taken at the height of the crisis may remain as the new normal in the provision of neurosurgical services and practices in Malaysia. The crisis has certainly put a strain on the effective delivery of services and as we approach the recovery era, what may have been a strain may prove to be a silver lining in neurosurgical services in Malaysia. The following details are various measures put in place as the new operational protocols for neurosurgical services in Malaysia.
    MeSH terms: Communicable Diseases; Emergency Service, Hospital; Health Personnel; Hospitals; Humans; Malaysia; Public Health; Coronavirus; Coronavirus Infections; Outsourced Services; Pandemics
  16. Asraf Ahmad Qamruddin, Ayu Malik, Reza Qamruddin
    MyJurnal
    Objectives: To determine the incidence rate of measles and the factors associated with confirmed measles cases in Larut, Matang and Selama districts. Methods: Cross-sectional analysis was carried out looking at all suspected and laboratoryconfirmed measles cases in Larut, Matang and Selama districts between 2015 and 2019. Multiple logistic regression analysis was used to determine the associated factors for laboratory-confirmed measles cases. Results: The incidence rate for suspected measles showed an increasing trend from 2015–2019. For laboratory-confirmed measles cases, the incidence rate showed more variation with an increase to 36.11 per million population in 2017 from 5.67 per million population in 2015. The incidence rate later decreased to 10.99 per million population in 2018 and increased again to 24.47 per million population in 2019. From multiple logistic regression analysis, cases that fulfilled the case definition of measles were more likely to be laboratory-confirmed measles. On the other hand, a prior history of measles immunisation was a protective factor. Conclusion: Measles incidence is increasing in trend. Any suspected measles cases that fulfilled the clinical case definitions need to be further investigated. Immunisation should be promoted as they are effective in preventing and eliminating measles.
    MeSH terms: Cross-Sectional Studies; Immunization; Laboratories; Measles; Vaccination; Incidence; Logistic Models; Protective Factors
  17. Xian, Leonard Leong Sang, Nallaluthan, Vasu, Yong, De Jun, Sanihah Abdul Halim, Chee, Yong Chuan, Zamzuri Idris, et al.
    MyJurnal
    Olfactory or smell dysfunction is often overlooked by clinicians despite being prevalent in the population. To date in Malaysia, there is no standard and reliable test to examine the function of olfaction. Tests used at developed countries such as the Sniffin’ Sticks Test (SST), the Connecticut Chemosensory Clinical Research Center (CCCRC) test, the University of Pennsylvania Smell Identification Test (UPSIT) and the Brief Smell Identification Test (B-SIT) are not readily available in this region and may be costly to procure. The first cranial nerve can be tested using commonly available materials to assess: i) the function of odour detection; ii) the odour discrimination; and iii) the odour identification. An abnormal odour detection threshold test generally indicates a peripheral olfactory problem while the odour discrimination and identification test attribute the problem to the cerebral cortex. An olfactory complaint should not be taken lightly and a proper olfactory function examination is important: i) to determine the legitimacy of a patient’s complaint; ii) to monitor the progress of patient’s olfactory function; iii) to establish insurance payout for disability; and iv) to characterise the specific nature of the problem. A video has been produced to demonstrate the examination techniques explained in this article.
    MeSH terms: Olfaction Disorders; Cerebral Cortex; Connecticut; Diagnostic Tests, Routine; Humans; Insurance; Malaysia; Olfactory Nerve; Smell; Developed Countries
  18. Lee CC, Kwa ALH, Apisarnthanarak A, Feng JY, Gluck EH, Ito A, et al.
    Clin Chem Lab Med, 2020 11 26;58(12):1983-1991.
    PMID: 31926074 DOI: 10.1515/cclm-2019-1122
    Introduction Recently, an expert consensus on optimal use of procalcitonin (PCT)-guided antibiotic stewardship was published focusing mainly on Europe and the United States. However, for Asia-Pacific countries, recommendations may need adaptation due to differences in types of infections, available resources and standard of clinical care. Methods Practical experience with PCT-guided antibiotic stewardship was discussed among experts from different countries, reflecting on the applicability of the proposed Berlin consensus algorithms for Asia-Pacific. Using a Delphi process, the group reached consensus on two PCT algorithms for the critically ill and the non-critically ill patient populations. Results The group agreed that the existing evidence for PCT-guided antibiotic stewardship in patients with acute respiratory infections and sepsis is generally valid also for Asia-Pacific countries, in regard to proposed PCT cut-offs, emphasis on diagnosis, prognosis and antibiotic stewardship, overruling criteria and inevitable adaptations to clinical settings. However, the group noted an insufficient database on patients with tropical diseases currently limiting the clinical utility in these patients. Also, due to lower resource availabilities, biomarker levels may be measured less frequently and only when changes in treatment are highly likely. Conclusions Use of PCT to guide antibiotic stewardship in conjunction with continuous education and regular feedback to all stakeholders has high potential to improve the utilization of antibiotic treatment also in Asia-Pacific countries. However, there is need for adaptations of existing algorithms due to differences in types of infections and routine clinical care. Further research is needed to understand the optimal use of PCT in patients with tropical diseases.
    MeSH terms: Algorithms; Bacterial Infections/diagnosis; Bacterial Infections/drug therapy; Humans; Respiratory Tract Infections/drug therapy; Sepsis/drug therapy; Consensus; Asian Continental Ancestry Group/genetics
  19. Wu M, Lu Y, Yang W, Wong SY
    Front Comput Neurosci, 2020;14:564015.
    PMID: 33469423 DOI: 10.3389/fncom.2020.564015
    Cardiovascular diseases (CVDs) are the leading cause of death today. The current identification method of the diseases is analyzing the Electrocardiogram (ECG), which is a medical monitoring technology recording cardiac activity. Unfortunately, looking for experts to analyze a large amount of ECG data consumes too many medical resources. Therefore, the method of identifying ECG characteristics based on machine learning has gradually become prevalent. However, there are some drawbacks to these typical methods, requiring manual feature recognition, complex models, and long training time. This paper proposes a robust and efficient 12-layer deep one-dimensional convolutional neural network on classifying the five micro-classes of heartbeat types in the MIT- BIH Arrhythmia database. The five types of heartbeat features are classified, and wavelet self-adaptive threshold denoising method is used in the experiments. Compared with BP neural network, random forest, and other CNN networks, the results show that the model proposed in this paper has better performance in accuracy, sensitivity, robustness, and anti-noise capability. Its accurate classification effectively saves medical resources, which has a positive effect on clinical practice.
    MeSH terms: Machine Learning; Arrhythmias, Cardiac; Cardiovascular Diseases; Cause of Death; Electrocardiography; Heart Rate; Technology
  20. Low QJ, Teo KZ, Thien LK, Lim TH, Cheo SW
    J R Coll Physicians Edinb, 2020 12;50(4):387-391.
    PMID: 33469613 DOI: 10.4997/JRCPE.2020.407
    BACKGROUND: Cardiac tamponade is a medical emergency. This study was carried out to determine the etiologies of cardiac tamponade and review the management and outcomes.

    METHODS: We retrospectively analysed case records of patients who underwent pericardiocentesis for cardiac tamponade during the two consecutive years (1 January 2018 to 31 December 2019) at Hospital Sultanah Nora Ismail, Batu Pahat, in Johor, Malaysia.

    RESULTS: There were ten patients (eight males, two females; age range 20 to 70 years old, mean age 36 years old) who underwent pericardiocentesis for cardiac tamponade during the said period. Malignancy (40%), tuberculosis (30%), idiopathic (20%), and bacterial (10%) were among the common causes of the pericardial effusion in this center. The commonest symptoms were breathlessness (90%), chest pain (60%), cough (50%), and unexplained fever (20%). Pulsus paradoxus was the most speciÿ c sign (100%) for the presence of echocardiographic feature of cardiac tamponade. Two of the patients with tuberculous pericarditis had retroviral disease; one patient had bacterial pericarditis due to salmonella typhi.

    CONCLUSION: This study has conÿ rmed that there are many etiologies and presentation of cardiac tamponade; clinicians should be alert as urgent pericardiocentesis is lifesaving.

    MeSH terms: Adult; Aged; Female; Humans; Male; Middle Aged; Retrospective Studies; Lung Diseases, Interstitial*; Pericardiocentesis; Young Adult
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