Development of the HIV360 international core set of outcome measures for adults living with HIV: A consensus process

Marques-Gomes J 1 , Salt MJ 2 , Pereira-Neto R 3 , Barteldes FS 1 , Gouveia-Barros V 2 , Carvalho A 4 Show all authors , d'Arminio-Monforte A 5 , De-la-Torre-Rosas A 6 , Harris A 7 , Esteves C 8 , Maor C 9 , Mora C 10 , Oliveira C 11 , Sousa C 12 , Richman DD 13 , Martinez E 14 , Cota-Medeiros F 15 , Gramacho F 15 , Behrens GMN 16 , Gonçalves G 15 , Farinha H 17 , Nabais I 15 , Vaz-Pinto I 18 , Sierra-Madero J 19 , Sousa-Gago J 3 , Thornhill J 20 , Vera J 21 , Erceg-Tusek M 22 , Tavares M 23 , Vasconcelos M 24 , Fernandes N 12 , Gianotti N 25 , Langebeek N 26 , Anjos P 27 , Couto R 28 , Fernandes R 29 , Rajasuriar R 30 , Serrão R 23 , Watson S 31 , Branco T 8 , Teixeira T 32 , Soriano V 33

Affiliations 

  • 1 Nova School of Business and Economics, Carcavelos, Portugal
  • 2 JPMG, Paris, France
  • 3 Nova Medical School, Nova University Lisbon, Lisbon, Portugal
  • 4 Braga Public Hospital, Braga, Portugal
  • 5 Institute of Infectious and Tropical Diseases - Department of Health Sciences, ASST Santi Paolo e Carlo University Hospital, Milan, Italy
  • 6 Ministry of Health, Mexico City, Mexico
  • 7 Aneurin Bevan University Health Board, NHS Wales, Newport, UK
  • 8 Portuguese Association for the Clinical Study of AIDS (APECS), Lisbon, Portugal
  • 9 Rambam Health Care Campus, Haifa, Israel
  • 10 AJPAS Association, Amadora, Portugal
  • 11 Santo António Hospital, Porto University Hospital Centre, Porto, Portugal
  • 12 Abraço Association, Lisbon, Portugal
  • 13 Center for AIDS Research, University of California San Diego, La Jolla, California, USA
  • 14 Hospital Clinic & University of Barcelona, Barcelona, Spain
  • 15 Northern Lisbon University Hospital Centre, Lisbon, Portugal
  • 16 Department for Rheumatology and Immunology, Hannover Medical School, Hannover, Germany
  • 17 Pharmacy Department, Egas Moniz Hospital, Western Lisbon Hospital Centre, Lisbon, Portugal
  • 18 HIV-AIDS Functional Unit, Cascais Hospital Dr. José de Almeida, Cascais, Portugal
  • 19 National Institute of Medical Sciences and Nutrition Salvador Zubirán, Mexico City, Mexico
  • 20 British HIV Association, London, UK
  • 21 HIV Disease Study Group, Portuguese Society of Internal Medicine (NEDVIH-SPMI), Lisbon, Portugal
  • 22 Croatian Association for HIV and Viral Hepatitis (HUHIV), Zagreb, Croatia
  • 23 São João University Hospital Centre, Porto, Portugal
  • 24 Division of Intervention in Addictive Behaviours and Dependencies (DICAD), Regional Health Administration of Lisbon and Tagus Valley, Lisbon, Portugal
  • 25 Infectious Diseases, San Raffaele Scientific Institute, Milan, Italy
  • 26 Rijnstate Hospital Arnhem, Arnhem, Netherlands
  • 27 Existências Association, Coimbra, Portugal
  • 28 Vila Nova de Gaia-Espinho Hospital Centre, Vila Nova de Gaia, Portugal
  • 29 GAT - Treatment Activists Group, Lisbon, Portugal
  • 30 Faculty of Medicine, University of Malaya, Kuala Lampur, Malaysia
  • 31 National HIV Nurses Association, London, UK
  • 32 Infectious Diseases Department, Vila Nova de Gaia-Espinho Hospital Centre, Vila Nova de Gaia, Portugal
  • 33 UNIR Health Sciences and Medical Center, Madrid, Spain
HIV Med, 2021 Dec 28.
PMID: 34964226 DOI: 10.1111/hiv.13221

Abstract

OBJECTIVES: HIV outcomes centre primarily around clinical markers with limited focus on patient-reported outcomes. With a global trend towards capturing the outcomes that matter most to patients, there is agreement that standardizing the definition of value in HIV care is key to their incorporation. This study aims to address the lack of routine, standardized data in HIV care.

METHODS: An international working group (WG) of 37 experts and patients, and a steering group (SG) of 18 experts were convened from 14 countries. The project team (PT) identified outcomes by conducting a literature review, screening 1979 articles and reviewing the full texts of 547 of these articles. Semi-structured interviews and advisory groups were performed with the WG, SG and people living with HIV to add to the list of potentially relevant outcomes. The WG voted via a modified Delphi process - informed by six Zoom calls - to establish a core set of outcomes for use in clinical practice.

RESULTS: From 156 identified outcomes, consensus was reached to include three patient-reported outcomes, four clinician-reported measures and one administratively reported outcome; standardized measures were included. The WG also reached agreement to measure 22 risk-adjustment variables. This outcome set can be applied to any person living with HIV aged > 18 years.

CONCLUSIONS: Adoption of the HIV360 outcome set will enable healthcare providers to record, compare and integrate standardized metrics across treatment sites to drive quality improvement in HIV care.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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