The Collaborative Ocular Tuberculosis Study (COTS) Consensus (CON) Group Meeting Proceedings

Agrawal R 1 , Testi I 2 , Mahajan S 3 , Yuen YS 4 , Agarwal A 5 , Rousselot A 6 Show all authors , Raje D 7 , Gunasekeran DV 1 , Kon OM 8 , Barisani-Asenbauer T 9 , Kempen JH 10 , Gupta A 5 , Jabs DA 11 , Smith JR 12 , Bodaghi B 13 , Zierhut M 14 , DeSmet M 15 , Cluskey PM 16 , Agarwal M 17 , Agarwal M 18 , Aggarwal K 5 , Agrawal M 19 , Al-Dhibi H 20 , Androudi S 21 , Asyari F 22 , Balasundaram MB 23 , Murthy KB 24 , Baglivo E 25 , Banker A 26 , Bansal R 5 , Basu S 27 , Behera D 5 , Biswas J 17 , Carreño E 28 , Caspers L 29 , Chee SP 30 , Chhabra R 31 , Cimino L 32 , Del Rio LEC 33 , Cunningham ET 34 , Curi ALL 35 , Das D 36 , Denisova E 37 , Denniston AK 2 , Errera MH 38 , Fonollosa A 39 , George A 17 , Goldstein DA 40 , Crosier YG 41 , Gurbaxani A 2 , Invernizzi A 42 , Isa HM 43 , Md Islam S 44 , Jones N 31 , Katoch D 5 , Khairallah M 45 , Khosla A 46 , Kramer M 47 , Kumar A 48 , Kumar A 49 , Nora RD 22 , Lee R 2 , Lowder C 50 , Luthra S 51 , Mahendradas P 52 , Makhoul D 29 , Mazumdar S 53 , Mehta S 54 , Miserocchi E 55 , Mochizuki M 56 , Mohamed OS 57 , Muccioli C 58 , Munk MR 59 , Murthy S 60 , Narain S 61 , Nascimento H 62 , Neri P 63 , Nguyen M 64 , Okada AA 65 , Ozdal P 66 , Palestine A 67 , Pichi F 63 , Rathinam SR 68 , Schlaen A 69 , Sehgal S 5 , Sen HN 70 , Sharma A 5 , Sharma K 5 , Shoughy SS 71 , Singh N 5 , Singh R 5 , Soheilian M 72 , Sridharan S 17 , Thorne JE 73 , Tappeiner C 59 , Teoh S 74 , Tognon MS 75 , Tugal-Tutkun I 76 , Tyagi M 77 , Uy H 78 , Santos DVV 79 , Valentincic NV 80 , Westcott M 2 , Yanai R 81 , Alvarez BY 82 , Zahedur R 83 , Nguyen QD 3 , Pavesio C 2 , Gupta V 5

Affiliations 

  • 1 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore
  • 2 Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom
  • 3 Byers Eye Institute, Stanford Medical School, Palo Alto, CA, United States
  • 4 Department of Ophthalmology, National University Hospital, Singapore, Singapore
  • 5 Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
  • 6 Department of Ophthalmology, Universidad del Salvador of Buenos Aires, Buenos Aires, Argentina
  • 7 MDS Bioanalytics, Nagpur, India
  • 8 Chest and Allergy Clinic, St Mary's Hospital, Imperial College Heathcare Service Trust, London, United Kingdom
  • 9 OCUVAC - Centre of Ocular Inflammation and Infection, Laura Bassi Centre of Expertise, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria
  • 10 Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts
  • 11 Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York
  • 12 Flinders University College of Medicine and Public Health, Adelaide, Australia
  • 13 Department of Ophthalmology, Sorbonne University, Paris, France
  • 14 Centre of Ophthalmology, University of Tuebingen, Tuebingen, Germany
  • 15 Department of Ophthalmology ZNA Middelheim, Antwerp, Belgium
  • 16 Department of Ophthalmology, Director Save Sight Institute, The University of Sydney, Sydney, Australia
  • 17 Sankara Nethralaya, Chennai, India
  • 18 Dr Shroff's Charity Eye Hospital Daryaganj, New Delhi, India
  • 19 VIMTA's Clinical Research and Clinical Reference Lab, Hyderabad, India
  • 20 King Khaled Eye Specialist Hospital, Riyadh, Kingdom of Saudi Arabia
  • 21 Department of Ophthalmology, University of Thessaly, Volos, Greece
  • 22 INOIIS, Department of Ophthalmology, University of Indonesia, Indonesia
  • 23 Aravind Eye Care System, Coimbatore, India
  • 24 Vittala International Institute of Ophthalmology, Bangalore, India
  • 25 Department of Ophthalmology, Clinique de l'oeil, Geneva, Switzerland
  • 26 Banker's Retina Clinic and Laser Centre, 5 Subhash Society, Ahmedabad, India
  • 27 LV Prasad Eye Institute, Bhubaneswar, India
  • 28 Hospital Universitario Fundación Jimenez Diaz, Madrid, Spain
  • 29 Department of Ophthalmology, CHU Saint-Pierre, Université Libre de Bruxelles (ULB), Brussels, Belgium
  • 30 Singapore Eye Research Institute, Singapore, Singapore
  • 31 Department of Ophthalmology, University of Manchester, Manchester, United Kingdom
  • 32 Ocular Immunology Unit, Azienda USL IRCCS, Reggio Emilia, Italy
  • 33 Asociacion Para Evitar La Ceguera En Mexico, Mexico City, Mexico
  • 34 Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA, USA
  • 35 Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Brazil
  • 36 Department of Ocular Pathology, Uveitis & Neuro-Ophthalmology Services, Sankaradeva Nethralaya, Guwahati, India
  • 37 Helmholtz Research Institute of Eye Diseases, Moscow, Russia
  • 38 Centre National d'Ophtalmologie des 15-20, Paris, Sorbonne-Universités, Paris 6, France
  • 39 Hospital Universitario Cruces, Cruces-Barakaldo, Bilbao, Vizcaya (Spain)
  • 40 Feinberg School of Medicine, Department of Ophthalmology, Northwestern University, Chicago, Illinois, USA
  • 41 Jules Gonin Eye Hospital, FAA, University of Lausanne, Lausanne, Switzerland
  • 42 Eye Clinic, Department of Biomedical and Clinical Science "L. Sacco", Luigi Sacco Hospital, University of Milan, Milan, Italy
  • 43 Gleneagles Hospital, Kuala Lumpur, Malaysia
  • 44 Ibn Sina Hospital, Dhaka, Bangladesh
  • 45 Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia
  • 46 Sir Ganga Ram Hospital, New Delhi, India
  • 47 Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel
  • 48 Department of Uvea, Aditya Birla Sankara Nethralaya, Kolkata, India
  • 49 Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
  • 50 Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA
  • 51 Drishti Eye Centre, Dehradun, Uttranchal, India
  • 52 Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India
  • 53 Department of Vitreoretina and Uvea, ICARE Eye Hospital and Postgraduate Institute, Noida, Uttar Pradesh, India
  • 54 Department of Ophthalmology, Lilavati Hospital and Research Center, Bandra Reclamation, Mumbai, India
  • 55 Ophthalmology Department, San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy
  • 56 Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
  • 57 Hospital Shah Alam, Shah Alam, Selangor, Malaysia
  • 58 Instituto da Visão, Hospital São Paulo, Universidade Federal de São Paulo, SP, Brazil
  • 59 Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
  • 60 Tej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, India
  • 61 Shroff Eye Centre, New Delhi, India
  • 62 Instituto da Visão, Hospital São Paulo, Universidade Federal de São Paulo (UNIFESP), SP, Brazil
  • 63 Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates
  • 64 Cao Thang Eye Hospital, Ho Chi Minh City, Vietnam
  • 65 Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
  • 66 Department of Ophthalmology, Ulucanlar Eye Education and Research Hospital, University of Health Sciences, Ankara, Turkey
  • 67 University of Colorado, Denver, CO, USA
  • 68 Aravind Eye Care System, Madurai, India
  • 69 Hospital Universitario Austral, Hospital de Clinicas "Jose de San Martín", Universidad de Buenos Aires, Buenos Aires, Argentina
  • 70 The Laboratory of Immunology, National Eye Institute, Bethesda, MD, USA
  • 71 The Eye Center and The Eye Foundation for Research in Ophthalmology, Riyad, Saudi Arabia
  • 72 Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 73 Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • 74 Eagle Eye Centre, Singapore, Singapore
  • 75 Ocular Immunology Unit, Department of Ophthalmology, S. Antonio Hospital, Padova, Italy
  • 76 Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Turkey
  • 77 LV Prasad Eye Institute, Hyderabad, India
  • 78 Ocular Immunology and Uveitis Service, Asian Eye Institute, Makati, Philippines
  • 79 Uveitis Unit, Hospital São Geraldo/Hospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
  • 80 Eye Hospital, UMC Ljubljana, Slovenia
  • 81 Yamaguchi University Hospital, Ube, Japan
  • 82 Dos De Mayo Hospital, Lima, Perù
  • 83 Eastern University, Bangladesh
Ocul Immunol Inflamm, 2020 Apr 06.
PMID: 32250731 DOI: 10.1080/09273948.2020.1716025

Abstract

An international, expert led consensus initiative was set up by the Collaborative Ocular Tuberculosis Study (COTS) group to develop systematic, evidence, and experience-based recommendations for the treatment of ocular TB using a modified Delphi technique process. In the first round of Delphi, the group identified clinical scenarios pertinent to ocular TB based on five clinical phenotypes (anterior uveitis, intermediate uveitis, choroiditis, retinal vasculitis, and panuveitis). Using an interactive online questionnaires, guided by background knowledge from published literature, 486 consensus statements for initiating ATT were generated and deliberated amongst 81 global uveitis experts. The median score of five was considered reaching consensus for initiating ATT. The median score of four was tabled for deliberation through Delphi round 2 in a face-to-face meeting. This report describes the methodology adopted and followed through the consensus process, which help elucidate the guidelines for initiating ATT in patients with choroidal TB.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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