Relationship of selective complement markers with schizophrenia

Mohd Asyraf AJ 1 , Nour El Huda AR 1 , Hanisah MN 2 , Norsidah KZ 1 , Norlelawati AT 3

Affiliations 

  • 1 Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
  • 2 Psychological Medicine Unit, Medical Faculty, Universiti Sultan Zainal Abidin, 24200 Kuala Terengganu, Terengganu, Malaysia
  • 3 Department of Pathology and Laboratory Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia. Electronic address: noleata@iium.edu.my
J Neuroimmunol, 2022 02 15;363:577793.
PMID: 34990981 DOI: 10.1016/j.jneuroim.2021.577793

Abstract

Immune system dysregulation may be involved in schizophrenia, but biomarker studies have thus far reported inconsistent findings. The relationship of plasma levels of complement markers C3 and C4, with schizophrenia, sociodemographic and clinico-psychological factors were here studied in 183 patients and 212 controls. C3 and C4 levels were significantly higher in the patients and in subjects with elevated C-reactive protein (CRP), and positively correlated with body mass index (BMI) (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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