Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses

Kalman JL 1 , Yoshida T 2 , Andlauer TFM 3 , Schulte EC 4 , Adorjan K 4 , Alda M 5 Show all authors , Ardau R 6 , Aubry JM 7 , Brosch K 8 , Budde M 4 , Chillotti C 6 , Czerski PM 9 , DePaulo RJ 10 , Forstner A 11 , Goes FS 10 , Grigoroiu-Serbanescu M 12 , Grof P 13 , Grotegerd D 14 , Hahn T 14 , Heilbronner M 4 , Hasler R 7 , Heilbronner U 4 , Heilmann-Heimbach S 15 , Kapelski P 9 , Kato T 16 , Kohshour MO 4 , Meinert S 14 , Meller T 8 , Nenadić I 8 , Nöthen MM 15 , Novak T 17 , Opel N 14 , Pawlak J 9 , Pfarr JK 8 , Potash JB 10 , Reich-Erkelenz D 4 , Repple J 14 , Richard-Lepouriel H 7 , Rietschel M 18 , Ringwald KG 8 , Rouleau G 19 , Schaupp S 4 , Senner F 4 , Severino G 20 , Squassina A 20 , Stein F 8 , Stopkova P 17 , Streit F 18 , Thiel K 14 , Thomas-Odenthal F 8 , Turecki G 21 , Twarowska-Hauser J 9 , Winter A 14 , Zandi PP 10 , Kelsoe JR 22 , Consortium on Lithium Genetics (ConLiGen), PsyCourse , Falkai P 23 , Dannlowski U 14 , Kircher T 8 , Schulze TG 4 , Papiol S 4

Affiliations 

  • 1 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany. janos.kalman@med.uni-muenchen.de
  • 2 National Center for Global Health and Medicine, Tokyo, Japan
  • 3 Department of Neurology, Klinikum Rechts Der Isar, School of Medicine, Technical University of Munich, Munich, Germany
  • 4 Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany
  • 5 Department of Psychiatry, Dalhousie University, Halifax, Canada
  • 6 Unit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy
  • 7 Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland
  • 8 Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany
  • 9 Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland
  • 10 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • 11 Centre for Human Genetics, University of Marburg, Marburg, Germany
  • 12 Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania
  • 13 Mood Disorders Clinic of Ottawa, Ottawa, ON, Canada
  • 14 Institute for Translational Psychiatry, University of Munster, Munster, Germany
  • 15 Institute of Human Genetics, School of Medicine &, University of Bonn, University Hospital Bonn, Bonn, Germany
  • 16 Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan
  • 17 National Institute of Mental Health, Klecany, Czech Republic
  • 18 Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany
  • 19 Montreal Neurological Institute, McGill University, Montreal, Canada
  • 20 Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
  • 21 The Douglas Research Centre, McGill University, Montreal, Canada
  • 22 Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
  • 23 Department of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany
Eur Arch Psychiatry Clin Neurosci, 2022 Dec;272(8):1611-1620.
PMID: 35146571 DOI: 10.1007/s00406-021-01366-5

Abstract

Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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