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Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections

Najafi S 1 , Tan SC 2 , Aghamiri S 1 , Raee P 3 , Ebrahimi Z 1 , Jahromi ZK 4 Show all authors , Rahmati Y 5 , Sadri Nahand J 6 , Piroozmand A 7 , Jajarmi V 8 , Mirzaei H 9

Affiliations 

  • 1 Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 2 UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • 3 Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 4 Central Research Laboratory, Jahrom University of Medical Sciences, Jahrom, Iran
  • 5 Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • 6 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • 7 Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
  • 8 Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: v.jajarmi@gmail.com
  • 9 Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: mirzaei-h@kaums.ac.ir
Biomed Pharmacother, 2022 Apr;148:112743.
PMID: 35228065 DOI: 10.1016/j.biopha.2022.112743

Abstract

Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel therapeutics. The CRISPR-Cas9 system has been recently proposed as a potential therapeutic tool for the treatment of viral diseases. Here, we review the research progress in the use of CRISPR-Cas technology for treating viral infections, as well as the strategies for improving the delivery of this gene-editing tool in vivo. Key challenges that hinder the widespread clinical application of CRISPR-Cas9 technology are also discussed, and several possible directions for future research are proposed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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