The effects of N-acetylcysteine on inflammatory and oxidative stress biomarkers: A systematic review and meta-analysis of controlled clinical trials

Faghfouri AH 1 , Zarezadeh M 2 , Tavakoli-Rouzbehani OM 3 , Radkhah N 4 , Faghfuri E 5 , Kord-Varkaneh H 6 Show all authors , Tan SC 7 , Ostadrahimi A 8

Affiliations 

  • 1 Nutrition Research Center, Department of Community Nutrition, Student Research Committee, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
  • 2 Nutrition Research Center, Department of Clinical Nutrition, Student Research Committee, School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: zarezadehm@tbzmed.ac.ir
  • 3 Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  • 4 School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  • 5 Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  • 6 Department of Clinical Nutrition and Dietetics, Student Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 7 UKM Medical Molecular Biology Institute, University of Kebangsaan Malaysia, Kuala Lampur, Malaysia
  • 8 Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: ostadrahimi@tbzmed.ac.ir
Eur J Pharmacol, 2020 Oct 05;884:173368.
PMID: 32726657 DOI: 10.1016/j.ejphar.2020.173368

Abstract

Prolonged inflammation could be considered as the leading cause of chronic diseases such as cardiovascular disorders, type two diabetes, and obesity. N-acetylcysteine (NAC) is considered an antioxidant. The present meta-analysis aims to determine the efficacy of NAC in alleviating inflammation and oxidative stress. PubMed-Medline, SCOPUS, Web of Science and Embase databases and Google Scholar were searched up to Nov 2019. Random effect analysis was used to perform meta-analysis. Subgroup analyses were carried out to find heterogeneity sources. Meta-regression analysis was used to explore linear relationship between effect size and variables. Trim and fill analysis were performed in case of the presence of publication bias. Quality assessment was performed using Cochrane Collaboration's tool. A total of 28 studies were included in meta-analysis. NAC significantly decreased malondialdehyde (MDA) (SMD = -1.44 μmol/L; 95% CI: -2.05, -0.84; P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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