The role of probiotic supplementation in inflammatory biomarkers in adults: an umbrella meta-analysis of randomized controlled trials

Faghfouri AH 1 , Afrakoti LGMP 2 , Kavyani Z 3 , Nogourani ZS 4 , Musazadeh V 5 , Jafarlou M 6 Show all authors , Dehghan P 7

Affiliations 

  • 1 Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran
  • 2 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  • 3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
  • 4 School of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran
  • 5 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Mosazadeh.vali05@gmail.com
  • 6 Faculty of Medicine and Health Science, UPM, 43400, Serdang, Malaysia
  • 7 Department of Clinical Nutrition, School of Nutrition and Food Sciences, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Dehghannut@gmail.com
Inflammopharmacology, 2023 Oct;31(5):2253-2268.
PMID: 37698776 DOI: 10.1007/s10787-023-01332-8

Abstract

OBJECTIVE: Despite the increasing evidence for probiotics' anti-inflammatory effects, the results of meta-analyses remain inconsistent. The present umbrella meta-analysis aimed to investigate the effects of probiotic supplementation on inflammatory biomarkers.

METHODS: We performed a wide-ranging systematic search in several databases, including PubMed, Web of Science, Scopus, EMBASE, and Google Scholar up to April 2023. The overall effect sizes were calculated using effect size (ES) values and their corresponding confidence intervals (CI).

RESULTS: Out of a total of 580 related articles, 39 studies were qualified for inclusion in the analysis. The results of the analysis revealed a significant reduction of C-reactive protein (CRP) (ES = -1.02; 95% CI: -1.23, -0.80, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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