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Evaluation of pre-treated healthcare wastes during COVID-19 pandemic reveals pathogenic microbiota, antibiotics residues, and antibiotic resistance genes against beta-lactams

Siew SW 1 , Musa SM 2 , Sabri N' 3 , Farida Asras MF 4 , Ahmad HF 5

Affiliations 

  • 1 Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Electronic address: shingwei999@gmail.com
  • 2 Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Electronic address: sitimunirahmusa93@gmail.com
  • 3 Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia; Group of Environment, Microbiology and Bioprocessing (GERMS), Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Electronic address: azyyatis@ump.edu.my
  • 4 Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia; Group of Environment, Microbiology and Bioprocessing (GERMS), Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Electronic address: mohdfazli@ump.edu.my
  • 5 Faculty of Industrial Sciences and Technology, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia; Group of Environment, Microbiology and Bioprocessing (GERMS), Lebuhraya Tun Razak, 26300, Gambang, Pahang, Malaysia. Electronic address: fauzanahmad@ump.edu.my
Environ Res, 2023 Feb 15;219:115139.
PMID: 36565841 DOI: 10.1016/j.envres.2022.115139

Abstract

The disposal of healthcare waste without prior elimination of pathogens and hazardous contaminants has negative effects on the environment and public health. This study aimed to profile the complete microbial community and correlate it with the antibiotic compounds identified in microwave pre-treated healthcare wastes collected from three different waste operators in Peninsular Malaysia. The bacterial and fungal compositions were determined via amplicon sequencing by targeting the full-length 16S rRNA gene and partial 18S with full-length ITS1-ITS2 regions, respectively. The antibiotic compounds were characterized using high-throughput spectrometry. There was significant variation in bacterial and fungal composition in three groups of samples, with alpha- (p-value = 0.04) and beta-diversity (p-values <0.006 and 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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