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Time from last immunity event against infection during Omicron-dominant period in Malaysia

Yang SL 1 , Ripen AM 2 , Lee JV 3 , Koh K 4 , Yen CH 5 , Chand AK 6 Show all authors , Abdul Rahim NAB 7 , Gokilavanan V 8 , Mohamed NNEB 9 , Sevalingam RKA 10 , Peariasamy KM 11

Affiliations 

  • 1 Centre for Clinical Epidemiology, Institute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Malaysia. Electronic address: sulanyang218@gmail.com
  • 2 Allergy & Immunology Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Malaysia. Electronic address: adiratna@moh.gov.my
  • 3 Clinical Research Centre, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, Malaysia. Electronic address: leejv85@gmail.com
  • 4 Clinical Research Centre, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, Malaysia. Electronic address: karinakoh.86@gmail.com
  • 5 Clinical Research Centre, Hospital Queen Elizabeth II, Ministry of Health Malaysia, Kota Kinabalu, Malaysia. Electronic address: skyych85@gmail.com
  • 6 Occupational Health Department, Hospital Queen Elizabeth, Ministry of Health Malaysia, Kota Kinabalu, Malaysia. Electronic address: oshdoctor@gmail.com
  • 7 Clinical Research Centre, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, Malaysia. Electronic address: dr.aisyahrahim@gmail.com
  • 8 Clinical Research Centre, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, Malaysia. Electronic address: varaleo24@gmail.com
  • 9 Clinical Research Centre, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, Malaysia. Electronic address: elizamohamed.crc@gmail.com
  • 10 Clinical Research Centre, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, Malaysia. Electronic address: rajkumarsevalingamcrc@gmail.com
  • 11 Institute for Clinical Research, National Institutes of Health, Ministry of Health Malaysia, Shah Alam, Malaysia. Electronic address: drkalai@moh.gov.my
Int J Infect Dis, 2023 Mar;128:98-101.
PMID: 36581187 DOI: 10.1016/j.ijid.2022.12.025

Abstract

OBJECTIVES: To study the incidence of Omicron infections in Malaysia and the exposures that could reduce the hazard of attaining Omicron infection.

METHODS: We used a multicenter, prospective cohort to study 482 healthcare workers vaccinated with two and three doses of BNT162b2 for SARS-CoV-2 infection during the Omicron-dominant period in Malaysia.

RESULTS: Between January 31 and July 31, 2022, the cumulative incidence was 44.6% (95% CI 40.2-49.1%), and the incidence rate was 3.33 (95% CI 2.91-3.80) per 1000 person-days. Our study found that protection against Omicron infection was significantly higher for persons with previous SARS-CoV-2 infection (hazard ratio [HR] 0.41, 95% CI 0.27-0.62) and persons with a more recent immunity event (<30 days [reference] vs >90 days, HR 3.82, 95%CI 1.34-10.90) from the beginning of the Omicron period.

CONCLUSION: Pre-Omicron natural infection and a recent immunity event protect against future Omicron infections.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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