Advances and opportunities in nanoimaging agents for the diagnosis of inflammatory lung diseases

Masanam HB 1 , Perumal G 2 , Krishnan S 3 , Singh SK 4 , Jha NK 5 , Chellappan DK 6 Show all authors , Dua K 7 , Gupta PK 8 , Narasimhan AK 1

Affiliations 

  • 1 Advanced Nano-Theranostics (ANTs), Biomaterials Lab, Department of Biomedical Engineering, SRM Institute of Science & Technology, Kattankulathur, Tamil Nadu, 603 203, India
  • 2 Department of Conservative Dentistry & Endodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Velappanchavadi, Chennai, 600 077, India
  • 3 Creative Carbon Labs Pvt Ltd, Chennai, Tamil Nadu, 600113, India
  • 4 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
  • 5 Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India
  • 6 Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil, Kuala Lumpur, 57000, Malaysia
  • 7 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia
  • 8 Department of Life Sciences, School of Basic Sciences & Research (SBSR), Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India
Nanomedicine (Lond), 2022 Oct;17(25):1981-2005.
PMID: 36695290 DOI: 10.2217/nnm-2021-0427

Abstract

The development of rapid, noninvasive diagnostics to detect lung diseases is a great need after the COVID-2019 outbreak. The nanotechnology-based approach has improved imaging and facilitates the early diagnosis of inflammatory lung diseases. The multifunctional properties of nanoprobes enable better spatial-temporal resolution and a high signal-to-noise ratio in imaging. Targeted nanoimaging agents have been used to bind specific tissues in inflammatory lungs for early-stage diagnosis. However, nanobased imaging approaches for inflammatory lung diseases are still in their infancy. This review provides a solution-focused approach to exploring medical imaging technologies and nanoprobes for the detection of inflammatory lung diseases. Prospects for the development of contrast agents for lung disease detection are also discussed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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