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Self-nanoemulsifying drug delivery system (SNEDDS) mediated improved oral bioavailability of thymoquinone: optimization, characterization, pharmacokinetic, and hepatotoxicity studies

Rathore C 1 , Hemrajani C 2 , Sharma AK 2 , Gupta PK 3 , Jha NK 4 , Aljabali AAA 5 Show all authors , Gupta G 6 , Singh SK 7 , Yang JC 8 , Dwivedi RP 9 , Dua K 10 , Chellappan DK 11 , Negi P 12 , Tambuwala MM 13

Affiliations 

  • 1 University Institute of Pharma Sciences, Chandigarh University, Ajitgarh, Punjab, India
  • 2 School of Pharmaceutical Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173 212, India
  • 3 Department of Life Sciences, School of Basic Sciences and Research (SBSR), Sharda University, Knowledge Park III, Greater Noida, Uttar Pradesh, 201310, India
  • 4 Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh, 201310, India
  • 5 Department of Pharmaceutics and Pharmaceutical Technology, Yarmouk University-Faculty of Pharmacy, Irbid, 21163, Jordan
  • 6 School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Jaipur, 302017, India
  • 7 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
  • 8 Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 110-52, Taiwan
  • 9 School of Electrical and Computer Science Engineering, Shoolini University, Solan, (H.P.), India
  • 10 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW, 2007, Australia
  • 11 Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia
  • 12 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, UK. poonam.546@shooliniuniversity.com
  • 13 School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, County Londonderry, BT52 1SA, Northern Ireland, UK. m.tambuwala@ulster.ac.uk
Drug Deliv Transl Res, 2023 Jan;13(1):292-307.
PMID: 35831776 DOI: 10.1007/s13346-022-01193-8

Abstract

Thymoquinone (TQ) is an antioxidant, anti-inflammatory, and hepatoprotective compound obtained from the black seed oil of Nigella sativa. However, high hydrophobicity, instability at higher pH levels, photosensitivity, and low oral bioavailability hinder its delivery to the target tissues. A self-nanoemulsifying drug delivery system (SNEDDS) was fabricated using the microemulsification technique to address these issues. Its physicochemical properties, thermodynamic stability studies, drug release kinetics, in vivo pharmacokinetics, and hepatoprotective activity were evaluated. The droplet size was in the nano-range (

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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