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Effects of curcumin-loaded poly(lactic-co-glycolic acid) nanoparticles in MDA-MB231 human breast cancer cells

Sharma A 1 , Hawthorne S 2 , Jha SK 3 , Jha NK 3 , Kumar D 4 , Girgis S 5 Show all authors , Goswami VK 6 , Gupta G 7 , Singh S 8 , Dureja H 9 , Chellappan DK 10 , Dua K 11

Affiliations 

  • 1 Department of Life Science, School of Basic Science & Research (SBSR), Sharda University, Uttar Pradesh, 201310, India
  • 2 School of Pharmacy & Pharmaceutical Sciences, Saad Centre for Pharmacy & Diabetes, Ulster University, Cromore Road, Coleraine, Co. Londonderry, BT52 1SA, UK
  • 3 Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Uttar Pradesh, 201310, India
  • 4 Amity Institute of Molecular Medicine & Stem Cell Research, Amity University, Noida, Uttar Pradesh, 201301, India
  • 5 School of Pharmacy, University of Sunderland, Chester Road, Sunderland, SR1 3SD, UK
  • 6 Department of Biological Sciences, School of Basic & Applied Sciences, G.D. Goenka University, Education city, Sohna Road, Gurugram, Haryana, 122103, India
  • 7 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, 302017, India
  • 8 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144402, India
  • 9 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India
  • 10 Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Kuala Lumpur, 57000, Malaysia
  • 11 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia
Nanomedicine (Lond), 2021 08;16(20):1763-1773.
PMID: 34296625 DOI: 10.2217/nnm-2021-0066

Abstract

Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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