Effects of processing and gamma radiation on mechanical properties and organic composition of frozen, freeze-dried and demineralised human cortical bone allograft

Mansor A 1 , Ariffin AF 2 , Yusof N 2 , Mohd S 2 , Ramalingam S 2 , Md Saad AP 3 Show all authors , Baharin R 4 , Min NW 5

Affiliations 

  • 1 Bone Bank, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia. azuraresearch@gmail.com
  • 2 Bone Bank, National Orthopaedic Centre of Excellence in Research and Learning (NOCERAL), Department of Orthopaedic Surgery, Faculty of Medicine, University of Malaya, Lembah Pantai, 50603, Kuala Lumpur, Malaysia
  • 3 Applied Mechanics and Design, School of Mechanical Engineering, Faculty of Engineering, Universiti Teknologi Malaysia, UTM Johor, 83130, Bahru, Malaysia
  • 4 Sinagama Irradiation Plant, Malaysian Nuclear Agency, Bangi, 43000, Kajang, Selangor, Malaysia
  • 5 Sunway Medical Centre, Bandar Sunway, 47500, Darul Ehsan, Selangor, Malaysia
Cell Tissue Bank, 2023 Mar;24(1):25-35.
PMID: 35610332 DOI: 10.1007/s10561-022-10013-9

Abstract

Bone processing and radiation were reported to influence mechanical properties of cortical bones due in part to structural changes and denaturation of collagen composition. This comparative study was to determine effects of bone processing on mechanical properties and organic composition, and to what extent the radiation damaging after each processing. Human femur cortical bones were processed by freezing, freeze-drying and demineralisation and then gamma irradiated at 5, 15, 20, 25 and 50 kGy. In the compression test, freeze drying significantly decreased the Young's Modulus by 15%, while demineralisation reduced further by 90% (P 

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