• 1 Universiti Kebangsaan Malaysia Medical Center, Department of Medicine, Kuala Lumpur, Malaysia
  • 2 Universiti Kebangsaan Malaysia, Faculty of Medicine, Department of Surgery, Breast and Endocrine Unit, Kuala Lumpur, Malaysia
  • 3 Universiti Kebangsaan Malaysia Medical Center, Department of Oncology, Kuala Lumpur, Malaysia
  • 4 Universiti Kebangsaan Malaysia Medical Center, Department of Pathology, Kuala Lumpur, Malaysia
  • 5 Universiti Kebangsaan Malaysia Medical Center, Department of Medicine, Kuala Lumpur, Malaysia.
Malays J Pathol, 2023 Aug;45(2):275-283.
PMID: 37658537


Thyroid carcinoma is uncommon. Papillary thyroid carcinoma (PTC) represents the majority of differentiated thyroid carcinoma and is a recognised complication of prior exposure to ionizing radiation. Even more uncommon is the synchronous occurrence of PTC with Hodgkin lymphoma (HL) as multiple primary malignancies. We report a 33-year-old mother of three who developed asymptomatic thyroid nodule for four years, and neck swelling for the recent ten months. She denied constitutional symptoms or B symptoms, and thyroid profiles were normal. Initially, metastatic thyroid cancer was suspected based on ultrasound scan findings of enlarged left thyroid gland and enlarged supraclavicular lymph nodes (LN). However, fine needle aspiration examinations of the thyroid nodule were inconclusive, and the supraclavicular LN was suspicious of HL. Computerised tomography scan detected a large mass at the thyroid glands and lymphadenopathies in the mediastinal, hilar, subcarinal and axilla with dimensions up to 6 cm. Left hemi-thyroidectomy with left supraclavicular LN biopsy revealed PTC in the left thyroid lobe measuring 38 x 25 x 18 mm, and the left supraclavicular LN was not definitive of HL. Completion thyroidectomy on the right side, bilateral central neck dissection and excision biopsy of the right supraclavicular LN revealed the presence of HL in the right supraclavicular LN, and both HL and metastatic PTC in right central LN. After multidisciplinary discussions, the patient received chemotherapy at four weeks postoperatively and achieved complete remission. This report highlights the importance of patient-centered approach and multidisciplinary consensus within lack of established guidelines, given rarity of the case.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.