Pooled rates and demographics of POTS following SARS-CoV-2 infection versus COVID-19 vaccination: Systematic review and meta-analysis

Yong SJ 1 , Halim A 2 , Liu S 3 , Halim M 4 , Alshehri AA 5 , Alshahrani MA 5 Show all authors , Alshahrani MM 5 , Alfaraj AH 6 , Alburaiky LM 7 , Khamis F 8 , Muzaheed 9 , AlShehail BM 10 , Alfaresi M 11 , Al Azmi R 12 , Albayat H 13 , Al Kaabi NA 14 , Alhajri M 15 , Al Amri KAS 16 , Alsalman J 17 , Algosaibi SA 18 , Al Fares MA 19 , Almanaa TN 20 , Almutawif YA 21 , Mohapatra RK 22 , Rabaan AA 23

Affiliations 

  • 1 Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Selangor, Malaysia. Electronic address: shin.y7@imail.sunway.edu.my
  • 2 Shanghai Medical College, Fudan University, Shanghai, China
  • 3 Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ontario, Canada; School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ontario, Canada
  • 4 Department of Biomedical Science, School of Science, Engineering and Environment, University of Salford, Greater Manchester, United Kingdom
  • 5 Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran, Saudi Arabia
  • 6 Pediatric Department, Abqaiq General Hospital, First Eastern Health Cluster, Abqaiq, Saudi Arabia
  • 7 Pediatric Department, Safwa General Hospital, Eastern Health Cluster, Safwa, Saudi Arabia
  • 8 Infection Diseases unit, Department of Internal Medicine, The Royal Hospital, Muscat, Oman
  • 9 Department of Clinical Laboratory Science, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • 10 Pharmacy Practice Department, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • 11 Department of Pathology and Laboratory Medicine, Zayed Military Hospital, Abu Dhabi, United Arab Emirates; Department of Pathology, College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates
  • 12 Infection Prevention and Control, Eastern Health Cluster, Dammam, Saudi Arabia
  • 13 Infectious Disease Department, King Saud Medical City, Riyadh, Saudi Arabia
  • 14 Sheikh Khalifa Medical City, Abu Dhabi Health Services Company, Abu Dhabi, United Arab Emirates; College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates
  • 15 Department of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • 16 Infection and Control Department, Armed Forces Hospital, Azaibah, Oman
  • 17 Infection Disease Unit, Department of Internal Medicine, Salmaniya Medical Complex, Ministry of Health, Manama, Bahrain
  • 18 Academic and Clinical Training, Eastern Health Cluster, Rural Health Network, Dammam, Saudi Arabia
  • 19 Department of Internal Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia
  • 20 Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia
  • 21 Department of Medical Laboratories Technology, College of Applied Medical Sciences, Taibah University, Madinah, Saudi Arabia
  • 22 Department of Chemistry, Government College of Engineering, Keonjhar, India
  • 23 Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Department of Public Health and Nutrition, The University of Haripur, Haripur, Pakistan. Electronic address: arabaan@gmail.com
Auton Neurosci, 2023 Dec;250:103132.
PMID: 38000119 DOI: 10.1016/j.autneu.2023.103132

Abstract

PURPOSE: To address recent concerns of postural orthostatic tachycardia syndrome (POTS) occurring after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination.

METHODS: We searched PubMed, Web of Science, and Scopus as of 1st June 2023. We performed a systematic review and meta-analysis of pooled POTS rate in SARS-CoV-2-infected and COVID-19-vaccinated groups from epidemiological studies, followed by subgroup analyses by characteristic. Meta-analysis of risk ratio was conducted to compare POTS rate in infected versus uninfected groups. Meta-analysis of demographics was also performed to compare cases of post-infection and post-vaccination POTS from case reports and series.

RESULTS: We estimated the pooled POTS rate of 107.75 (95 % CI: 9.73 to 273.52) and 3.94 (95 % CI: 0 to 16.39) cases per 10,000 (i.e., 1.08 % and 0.039 %) in infected and vaccinated individuals based on 5 and 2 studies, respectively. Meta-regression revealed age as a significant variable influencing 86.2 % variance of the pooled POTS rate in infected population (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications