• 1 School of Chemistry, University of Wollongong , Wollongong, New South Wales 2522, Australia
J Nat Prod, 2014 Apr 25;77(4):894-901.
PMID: 24606395 DOI: 10.1021/np400978x


Four new stichoneurine-type alkaloids, stichoneurines F and G (1-2) and sessilistemonamines E and F (3-4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1-4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1±0.15 μM.

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