Non-hypertensive gestational diabetes mellitus: Placental histomorphology and its association with perinatal outcomes

Lai YM 1 , Tan GC 1 , Shah SA 2 , Abd Rahman R 3 , Mohd Saleh MF 1 , Mansor S 1 Show all authors , Khong TY 4 , Wong YP 5

Affiliations 

  • 1 Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, 56000, Kuala Lumpur, Malaysia
  • 2 Department of Community Health, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, 56000, Kuala Lumpur, Malaysia
  • 3 Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, 56000, Kuala Lumpur, Malaysia
  • 4 Department of Pathology, Women's and Children's Hospital, Adelaide, SA 5006, Australia
  • 5 Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, 56000, Kuala Lumpur, Malaysia. Electronic address: ypwong@ppukm.ukm.edu.my
Placenta, 2024 Mar 06;147:21-27.
PMID: 38278001 DOI: 10.1016/j.placenta.2024.01.012

Abstract

INTRODUCTION: Gestational diabetes mellitus (GDM) exerts a great impact on the placenta and reflects changes on placentas both morphological and functionally. The aims of this study are to evaluate the prevalence of placental histopathological lesions in pregnancies complicated by GDM compared to gestational age-matched controls, and their association with maternal and fetal complications.

METHODS: Fifty-four singleton GDM-complicated pregnancies were recruited and compared to 33 consecutive normal pregnancies. Two pathologists, blinded to all clinical data, reviewed and evaluated all histological samples of the placentas in accordance with Amsterdam criteria. Relevant demographic, clinical data and primary birth outcomes were recorded.

RESULTS: A myriad of histomorphological abnormalities, including chronic inflammation (n = 9/54, p = 0.031), histological chorioamnionitis (n = 23/54, p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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