Ionic liquid-mediated ethosome for transdermal delivery of insulin

Nabila FH 1 , Islam R 1 , Shimul IM 2 , Moniruzzaman M 3 , Wakabayashi R 1 , Kamiya N 1 Show all authors , Goto M 1

Affiliations 

  • 1 Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. m-goto@mail.cstm.kyushu-u.ac.jp
  • 2 Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore-7408, Bangladesh
  • 3 Department of Chemical Engineering, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia
Chem Commun (Camb), 2024 Apr 09;60(30):4036-4039.
PMID: 38466016 DOI: 10.1039/d3cc06130b

Abstract

Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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