Affiliations 

  • 1 Faculty of Innovation and Technology, School of Engineering, Chemical Engineering Programme, No.1 Jalan Taylor's, Taylor's University Malaysia, 47500 Subang Jaya, Selangor, Malaysia. Electronic address: b.nasiritabrizi@gmail.com
  • 2 Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: jeff@um.edu.my
  • 3 Faculty of Innovation and Technology, School of Engineering, Chemical Engineering Programme, No.1 Jalan Taylor's, Taylor's University Malaysia, 47500 Subang Jaya, Selangor, Malaysia; Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh 174103, India
  • 4 School of Medicine, Faculty of Health and Medical Sciences, Taylor's University, 47500 Subang Jaya, Malaysia
  • 5 Faculty of Innovation and Technology, School of Engineering, Chemical Engineering Programme, No.1 Jalan Taylor's, Taylor's University Malaysia, 47500 Subang Jaya, Selangor, Malaysia
Biomater Adv, 2024 Apr 16;161:213854.
PMID: 38703541 DOI: 10.1016/j.bioadv.2024.213854

Abstract

This review delves into the utilization of intermetallic alloys (IMAs) as advanced biomaterials for medical implants, scrutinizing their conceptual framework, fabrication challenges, and diverse manufacturing techniques such as casting, powder metallurgy, and additive manufacturing. Manufacturing techniques such as casting, powder metallurgy, additive manufacturing, and injection molding are discussed, with specific emphasis on achieving optimal grain sizes, surface roughness, and mechanical properties. Post-treatment methods aimed at refining surface quality, dimensional precision, and mechanical properties of IMAs are explored, including the use of heat treatments to enhance biocompatibility and corrosion resistance. The review presents an in-depth examination of IMAs-based implantable biomaterials, covering lab-scale developments and commercial-scale implants. Specific IMAs such as Nickel Titanium, Titanium Aluminides, Iron Aluminides, Magnesium-based IMAs, Zirconium-based IMAs, and High-entropy alloys (HEAs) are highlighted, with detailed discussions on their mechanical properties, including strength, elastic modulus, and corrosion resistance. Future directions are outlined, with an emphasis on the anticipated growth in the orthopedic devices market and the role of IMAs in meeting this demand. The potential of porous IMAs in orthopedics is explored, with emphasis on achieving optimal pore sizes and distributions for enhanced osseointegration. The review concludes by highlighting the ongoing need for research and development efforts in IMAs technologies, including advancements in design and fabrication techniques.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.