Suicidality is most centrally situated within network of depression symptom criteria in unipolar depression patients with mood stabilizer in Asia

Yoon JW 1 , Kim E 2 , Jeong N 3 , Kang M 4 , Kim HS 1 , Lee S 5 Show all authors , Yoon HJ 6 , Kim SG 6 , Na E 7 , Yang H 8 , Park JH 8 , Yang SY 9 , Lin SK 10 , Zhu X 11 , Xiang YT 12 , Sim K 13 , Tan CH 14 , Grover S 15 , Avasthi A 15 , Kallivayalil RA 16 , Maramis MM 17 , Chee KY 18 , Pariwatcharakul P 19 , Oo T 20 , Kato TA 21 , Javed A 22 , Chong MY 23 , Sartorius N 24 , Shinfuku N 25 , Park J 26 , Park SC 27

Affiliations 

  • 1 Department of Psychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea
  • 2 Department of Psychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea; Department of Premedicine, Hanyang University College of Medicine, Seoul, Republic of Korea
  • 3 Department of Clinical Psychology, Yong-In Mental Hospital, Yongin, Republic of Korea
  • 4 Department of Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea
  • 5 Department of Psychiatry, Hanyang University Seoul Hospital, Seoul, Republic of Korea
  • 6 Department of Psychiatry, Chosun University Hospital, Gwangju, Republic of Korea
  • 7 Department of Psychiatry, Presbyterian Medical Center, Jeonju, Republic of Korea
  • 8 Department of Psychiatry, Jeju National University Hospital, Jeju, Republic of Korea
  • 9 Department of Pharmacy, Taipei City Hospital, Taipei, Taiwan
  • 10 Department of Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; Department of Psychiatry, Taipei City Hospital and Psychiatric Center, Taipei, Taiwan
  • 11 Department of Psychiatry, Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow University, Suzhou, China
  • 12 Unit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences & Centre for Cognitive and Brain Sciences, University of Macau, Macau SAR, China
  • 13 Institute of Mental Health, Buangkok Green Medical Park, Singapore
  • 14 Department of Pharmacology, National University of Singapore, Singapore
  • 15 Department of Psychiatry, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  • 16 Department of Psychiatry, Pushpagiri Institute of Medical Sciences, Tiruvalla, India
  • 17 Department of Psychiatry, Dr. Soetomo Hospital - Faculty of Medicine, Airlangga University, Surabaya, Indonesia
  • 18 Department of Psychiatry & Mental Health, Tunku Abdul Rahman Institute of Neurosciences, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
  • 19 Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
  • 20 Mental Health Hospital, Yangon University of Medicine, Yangon, Myanmar
  • 21 Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • 22 Pakistan Psychiatric Research Centre, Fountain House, Lahore, Pakistan; Institute of Applied Health Research, University of Birmingham, UK
  • 23 Health Management International, Singapore; Regency Specialist Hospital, Johor, Malaysia
  • 24 Association for the Improvement of Mental Health Programs, Geneva, Switzerland
  • 25 School of Human Sciences, Seinan Gakuin University, Fukuoka, Japan
  • 26 Department of Psychology, Ajou University, Suwon, Republic of Korea
  • 27 Department of Psychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea; Department of Psychiatry, Hanyang University College of Medicine, Seoul, Republic of Korea; Hanyang Institute of Bioscience and Biotechnology, Hanyang University, Seoul, Republic of Korea. Electronic address: psc76@hanyang.ac.kr
Asian J Psychiatr, 2024 Aug 30;101:104197.
PMID: 39250855 DOI: 10.1016/j.ajp.2024.104197

Abstract

Lithium and mood stabilizers are considered effective augmentation agents of antidepressants for treatment-resistant depression. Thus, this study aimed to estimate the network structure of depression symptom criteria among unipolar depression patients with mood stabilizers, using data from the Research on Asian Psychotropic Prescription Patterns for mood stabilizers (REAP-MS). We estimated a network of the 9 depression symptom criteria among 411 unipolar depression patients in Asia. Each of the depression symptom criteria was considered to be a dichotomous categorical variable. Suicidality (suicidal ideation or attempt) was the most centrally situated within the network of depression symptoms, followed by depressed mood, loss of energy, anhedonia and weight loss or gain. Contrastingly, concentration problem was the least interconnected. The depression symptom criteria were organized into 4 clusters by the community detection method. The findings suggest that suicidality may be one of the significant therapeutic target symptoms in unipolar depression patients with mood stabilizers.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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