Design strategies of polysaccharide, protein and lipid-based nano-delivery systems in improving the bioavailability of polyphenols and regulating gut homeostasis

Guo X 1 , Liu H 1 , Hou R 2 , Chen G 2 , Xiao H 3 , Liu L 4 Show all authors , Ciftci ON 4 , Liu L 5

Affiliations 

  • 1 State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Technology, Ningbo University, Ningbo, Zhejiang, PR China
  • 2 Anhui Agricultural University, School Tea & Food Science & Technololgy, State Key Lab Tea Plant Biolology & Utilizatilizaytion, Key Lab Food Nutrion & Safety, Hefei 230036, PR China
  • 3 Department of Food Science, University of Massachusetts, Amherst 01003, USA
  • 4 Department of Food Science and Technology, University of Nebraska, Lincoln, NE, USA
  • 5 State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Key Laboratory of Animal Protein Deep Processing Technology of Zhejiang, Zhejiang-Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food Science and Technology, Ningbo University, Ningbo, Zhejiang, PR China. Electronic address: lianliang626@hotmail.com
Int J Biol Macromol, 2024 Dec;283(Pt 4):137463.
PMID: 39547604 DOI: 10.1016/j.ijbiomac.2024.137463

Abstract

Polyphenols are plant secondary metabolites that have attracted much attention due to their anti-inflammatory, antioxidant, and gut homeostasis promoting effects. However, food matrix interaction, poor solubility, and strong digestion and metabolism of polyphenols cause barriers to their absorption in the gastrointestinal tract, which further reduces bioavailability and limits polyphenols' application in the food industry. Nano-delivery systems composed of biocompatible macromolecules (polysaccharides, proteins and lipids) are an effective way to improve the bioavailability of polyphenols. Therefore, this review introduces the construction of biopolymer-based nano-delivery systems and their application in polyphenols, with emphasis on improving the solubility, stability, sustained release and intestinal targeting of polyphenols. In addition, there are possible positive effects of polyphenol-loaded nano-delivery systems on modulating gut microbiota and gut homeostasis, with particular emphasis on modulating intestinal inflammation, metabolic syndrome, and gut-brain axis. It is worth noting that the safety of bio-based nano-delivery systems still need to be further studied. In summary, the application of the bio-based nano-delivery system to deliver polyphenols provides insights for improving the bioavailability of polyphenols and for the treatment of potential diseases in the future.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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