Affiliations 

  • 1 School of Pharmaceutical Sciences, Shoolini University, Solan 173229, Himachal Pradesh, India
  • 2 Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, Haryana, India
  • 3 Swami Vivekanand College of Pharmacy, Near Banur, Rajpura, Patiala, Punjab, 140601, India
  • 4 Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University,Taipei 110-52, Taiwan
  • 5 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
  • 6 Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab 140401, India; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates
  • 7 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology, Sydney, Ultimo, NSW 2007, Australia
  • 8 Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology, Sydney, Ultimo, NSW 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
  • 9 School of Pharmaceutical Sciences, Shoolini University, Solan 173229, Himachal Pradesh, India. Electronic address: poonamgarge@gmail.com
Carbohydr Polym, 2025 Jan 15;348(Pt A):122809.
PMID: 39562084 DOI: 10.1016/j.carbpol.2024.122809

Abstract

Non-toxic, biocompatible, biodegradable, and bioadhesive, characteristics, of natural polysaccharides, are widely recognized and well accepted. Their usage in dietary, medicinal, biomedical, and cosmetic, applications is due to their unique and fascinating attributes. Xanthan gum, a microbial polysaccharide possesses diverse-wonderful features. It is a naturally occurring heteropolysaccharide, with large molecular weight, derived from the Gram-negative bacteria, Xanthomonas Campestris. This biopolymer has been studied extensively as a matrix for tablets, nanoparticles, microparticles, hydrogels, and various other formulation types. However, indigenous xanthan gum has its own set of restrictions, which may be overcome by chemical modification, to fine-tune the characteristics of the native gum, for attaining unmet demands. This approach has huge potential in the drug delivery and numerous other promising applications. The objective of this review is to provide a consolidated source of information on xanthan gum-based gastroretentive systems. Several approaches of floating techniques, with recent research avenues and patents, utilizing the natural polysaccharide xanthan gum is also discussed.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.