Affiliations 

  • 1 Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Seri Kembangan, Selangor, Malaysia; Department of Dietetics and Food Service, Institut Kanser Negara, Ministry of Health Malaysia, 4, Jalan P7, Presint 7, 62250 Wilayah Persekutuan Putrajaya, Malaysia. Electronic address: agneshcy0326@gmail.com
  • 2 Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Seri Kembangan, Selangor, Malaysia. Electronic address: bnisak@upm.edu.my
  • 3 School of Health and Rehabilitation Sciences, AECC University College, Parkwood Campus, Parkwood Road, Bournemouth Dorset, BH5 2DF, United Kingdom; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: hazreen.abdulmajid@gmail.com
  • 4 Department of Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Seri Kembangan, Selangor, Malaysia. Electronic address: zulfitri@upm.edu.my
Clin Nutr ESPEN, 2024 Dec;64:168-176.
PMID: 39362334 DOI: 10.1016/j.clnesp.2024.09.022

Abstract

BACKGROUND: Gynecologic cancer (GC) patients often experience systemic inflammation, malnutrition, and compromised postoperative outcomes. This systematic review aims to comprehensively synthesize existing data regarding the impact of perioperative immunonutrition (IMN) intervention on GC patients.

METHODS: The databases of CENTRAL, EMBASE, Web of Science, and the Cochrane Library were used to conduct a literature search, supplemented by internet search engines and manual searches. Publications released between January 2009 and October 2023 was identified, reviewed, and data extracted.

RESULTS: The review encompasses six studies involving 712 patients, comprising two randomized controlled trials (RCTs), two prospective studies, and two retrospective cohort studies. Three studies prescribed IMN perioperatively; two pre-operatively and one post-operatively. Four out of six studies reported less post-operative infection and complications. Two studies reported shorter hospitalization using the IMN formula. One study reported a longer hospitalization with IMN supplementation. Overall survival showed no significant difference in the two studies. Four studies reported positive modulation of inflammatory markers and lymphocytes as outcomes, with IMN formulas.

DISCUSSION AND CONCLUSION: Perioperative IMN emerge as a promising intervention, demonstrating notable benefits included shortened hospitalization as well and positive modulation of inflammatory markers.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.