An in vitro evaluation of anti-oxidant properties of novel nano-composite material containing titanium oxide, zinc oxide and green tea extract

Joseph S 1 , Nallaswamy D 2 , Rajeshkumar S 3 , Dathan PC 2 , Rasheed N 2 , Tharani M 4 Show all authors , Jacob J 5 , Jose L 6

Affiliations 

  • 1 MDS, PhD Research Scholar, Department of Prosthodontics Saveetha Dental College and Hospitals, SIMATS, Chennai, India. sjkt21@gmail.com
  • 2 Department of Prosthodontics, Saveetha Dental College and Hospitals, SIMATS, Chennai, India
  • 3 Nanomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai, India
  • 4 Department of Pharmacology, Saveetha Dental College and Hospitals, SIMATS, Chennai, India
  • 5 Department of Conservative Dentistry, Pushpagiri College of Dental Science, Thiruvalla, India
  • 6 Department of Mechanical engineering, IIT Madras
Med J Malaysia, 2025 Jan;80(Suppl 1):52-58.
PMID: 39773943

Abstract

INTRODUCTION: Green tea is a medicinal beverage extracted from the plant Camellia sinensis. Antioxidants that exist naturally can be extracted as pure compounds from their parent materials for nutraceutical and medicinal applications. The present study aims to assess the antioxidant activity of Zinc oxide-titanium dioxide nano-composites (ZnO-TiO2 NCs) containing green tea extract.

MATERIALS AND METHODS: The antioxidant activity was tested by Hydrogen Peroxide [H2O2] assay, Fluorescence recovery after photo-bleaching [FRAP] assay and 2, 2-diphenyl-1- picrylhydrazyl[DPPH] assay. All tests have shown very good results for the ZnO-TiO2 NCs.

RESULTS: In this study, we present a straightforward, ecofriendly alternative for producing non-toxic zinc oxide and titanium oxide nano-composite material. This study could make a valuable contribution and create new opportunities in the market such as biological and pharmaceutical applications.

CONCLUSION: The in vitro tests concluded that the novel nanocomposite containing ZnO-TiO2 and green tea extract has good anti-oxidant properties and it is non-toxic to the biological systems.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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