The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics

Balaraman AK 1 , Altamimi ASA 2 , Babu MA 3 , Goyal K 4 , PadmaPriya G 5 , Bansal P 6 Show all authors , Rajotiya S 7 , Kumar MR 8 , Rajput P 9 , Imran M 10 , Gupta G 11 , Thangavelu L 12

Affiliations 

  • 1 Research and Enterprise, University of Cyberjaya, Persiaran Bestari Cyber 11, Cyberjaya, Selangor, 63000, Malaysia
  • 2 Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam bin Abdulaziz University, 11942, Al Kharj, Saudi Arabia
  • 3 Institute of Pharmaceutical Research, GLA University, Uttar Pradesh, Mathura, India
  • 4 Department of Biotechnology, Graphic Era (Deemed to Be University), Clement Town, Dehradun, 248002, India
  • 5 Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India
  • 6 Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India
  • 7 NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, India
  • 8 Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, India
  • 9 Division of Research and Innovation, Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
  • 10 Department of Pharmaceutical Chemistry, College of Pharmacy, Northern Border University, 91911, Rafha, Saudi Arabia
  • 11 Centre for Research Impact & Outcome, Chitkara College of Pharmacy, Chitkara University, Punjab, India
  • 12 Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. drlakshmi.thangavelu25@gmail.com
Biogerontology, 2025 Jan 20;26(1):46.
PMID: 39832057 DOI: 10.1007/s10522-025-10190-6

Abstract

Aging is associated with a marked increase in cardiovascular diseases, such as myocardial infarction (MI). Cellular senescence is also a crucial factor in the development of age-related MI. Matrix metalloproteinases (MMPs) interaction with cellular senescence is a critical determinant of MI development and outcomes, most notably in the aged heart. After experiencing a heart attack, senescent cells exhibit a Senescence-Associated Secretory Phenotype (SASP) and are involved in tissue regeneration and chronic inflammation. MMPs are necessary for extracellular matrix proteolysis and have a biphasic effect, promoting early heart healing and detrimental change if overexpressed shortly. This review analyses the complex connection between senescence and MMPs in MI and how it influences elderly cardiac performance. Critical findings suggest that increasing cellular senescence in aged hearts elevates MMP activity and aggravates extended ventricular remodeling and dysfunction. Additionally, we explore potential therapeutics that address MMPs and senescence to enhance old MI patient myocardial performance and regeneration.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications