Mortality Projections, Regional Disparities in the Burden of Neonatal Disorders, and the Status of Achieving SDG Targets by 2030 in South Asia: Insights from the Global Burden of Disease Study 2021

Soni M 1 , Khatib MN 2 , Balaraman AK 3 , Roopashree R 4 , Kaur M 5 , Srivastava M 6 Show all authors , Barwal A 7 , Prasad GVS 8 , Rajput P 9 , Syed R 10 , Sharma G 11 , Kumar S 12 , Bushi G 13 , Chilakam N 14 , Pandey S 15 , Brar M 16 , Mehta R 17 , Sah S 18 , Shabil M 19 , Gaidhane AM 20 , Singh M 21

Affiliations 

  • 1 Evidence for Policy and Learning, Global Center for Evidence Synthesis, Chandigarh, India
  • 2 Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India
  • 3 Research and Enterprise, University of Cyberjaya, Persiaran Bestari, Cyber 11, 63000, Cyberjaya, Selangor, Malaysia
  • 4 Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India
  • 5 Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India
  • 6 Department of Endocrinology, NIMS University, Jaipur, India
  • 7 Chandigarh Pharmacy College, Chandigarh Group of College, Jhanjeri, Mohali, Punjab, 140307, India
  • 8 Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, India
  • 9 School of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, India
  • 10 IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, 462044, India
  • 11 New Delhi Institute of Management, Tughlakabad Institutional Area, New Delhi, India
  • 12 Department of Microbiology, Graphic Era (Deemed to be University), Clement Town, Dehradun, 248002, India
  • 13 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India
  • 14 Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India
  • 15 Centre of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, 140417, India
  • 16 Chitkara Centre for Research and Development, Chitkara University, Himachal Pradesh, 174103, India
  • 17 Clinical Microbiology, RDC, Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, 121004, India
  • 18 SR Sanjeevani Hospital, Kalyanpur, Siraha, 56517, Nepal. sanjitsahnepal561@gmail.com
  • 19 University Center for Research and Development, Chandigarh University, Mohali, Punjab, India
  • 20 Jawaharlal Nehru Medical College, and Global Health Academy, School of Epidemiology and Public Health, Datta Meghe Institute of Higher Education, Wardha, India
  • 21 Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
J Epidemiol Glob Health, 2025 Mar 13;15(1):43.
PMID: 40080234 DOI: 10.1007/s44197-025-00359-0

Abstract

BACKGROUND: Neonatal disorders represent a significant public health challenge, particularly in low- and middle-income countries, where they account for 79% of global neonatal mortality. South Asia, comprising countries such as India, Pakistan, Bangladesh, Nepal, and Bhutan, bears a disproportionately high burden, contributing to 38% of the world's neonatal deaths. Despite notable progress, South Asia remains off track in meeting the Sustainable development goals (SDG). This study aims to assess the current burden, trends in neonatal disorders, and forecast mortality rates across South Asian countries, providing insights to guide investment priorities and improve neonatal outcomes.

METHODS: Data for this study were sourced from the Global burden of disease (GBD) 2021 study, which utilizes a Bayesian meta-regression model to estimate mortality, prevalence, and disability-adjusted life years (DALYs). Spatial maps depicting the age-standardized prevalence rate and age-standardized mortality rate for neonatal disorders in South Asia were generated using QGIS software. Mortality forecasts for the period 2022-2031, attributed to various neonatal disorders, were produced employing the Auto-Regressive Integrated Moving Average model in R software. Additionally, an analysis of overall neonatal mortality trends from 1980 to 2021 was conducted, supplemented by a heat map that compares DALYs attributable to various neonatal disorders across South Asian countries in 2021.

RESULTS: Between 1980 and 2021, South Asia experienced a substantial decline in neonatal mortality rates, with India and Bangladesh leading the progress. Mortality decreased by 40%, while DALYs fell by 35%, despite a 15% increase in the prevalence. The prevalence of neonatal encephalopathy due to birth asphyxia and trauma surged by 355%, yet its mortality dropped by 31%. Pakistan recorded the highest neonatal mortality and disease burden, particularly for hemolytic disease and other neonatal jaundice and neonatal encephalopathy due to birth asphyxia and trauma. In India and Bangladesh, neonatal preterm birth and neonatal sepsis and other neonatal infections contributed most to mortality. Neonatal encephalopathy due to birth asphyxia and trauma accounted for the highest DALYs. Forecasts predict continued reductions in neonatal mortality across South Asia, except in Pakistan, where persistently high rates are expected till 2031.

CONCLUSION: For South Asian countries to meet the SDG target for neonatal mortality by 2030, intensified and continuous efforts are required. These efforts should focus on identifying high-risk pregnancies and improving the quality of care during childbirth to address the root causes and reduce preventable neonatal deaths.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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