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Association of HIV infection and hospitalization among mpox cases: a systematic review and meta-analysis

Shabil M 1 , Gaidhane S 2 , Roopashree R 3 , Kaur M 4 , Srivastava M 5 , Barwal A 6 Show all authors , Siva Prasad GV 7 , Rajput P 8 , Syed R 9 , Dev A 10 , Kundra D 11 , Yappalparvi A 12 , Satapathy P 13 , Zahiruddin QS 14 , Kumar H 15 , Sah R 16 , Bushi G 17

Affiliations 

  • 1 University Center for Research and Development, Chandigarh University, Mohali, Punjab, India
  • 2 One Health Centre (COHERD), Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education, Wardha, India
  • 3 Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India
  • 4 Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India
  • 5 Department of Endocrinology, NIMS University, Jaipur, India
  • 6 Chandigarh Pharmacy College, Chandigarh Group of College, Jhanjeri, Mohali1, Punjab, 140307, India
  • 7 Department of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, India
  • 8 School of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, India
  • 9 IES Institute of Pharmacy, IES University, Bhopal, Madhya Pradesh, 462044, India
  • 10 Centre of Research Impact and Outcome, Chitkara University, Rajpura, Punjab, 140417, India
  • 11 Chitkara Centre for Research and Development, Chitkara University, Solan, Himachal Pradesh, 174103, India
  • 12 Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India
  • 13 Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha Medical College and Hospital, Saveetha University, Chennai, India
  • 14 South Asia Infant Feeding Research Network (SAIFRN), Division of Evidence Synthesis, Global Consortium of Public Health and Research, Datta Meghe Institute of Higher Education, Wardha, India. zahirquazi@dmiher.edu.in
  • 15 New Delhi Institute of Management, Tughlakabad Institutional Area, New Delhi, India
  • 16 SR Sanjeevani Hospital, Kalyanpur, Siraha, 56517, Nepal. renusahdoc@gmail.com
  • 17 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, India
BMC Infect Dis, 2025 Jan 22;25(1):102.
PMID: 39844097 DOI: 10.1186/s12879-025-10512-6

Abstract

BACKGROUND: Mpox is a viral zoonotic disease that has seen a resurgence in recent years, with outbreaks reaching beyond its traditional endemic zones in Central and West Africa to parts of Europe and North America. The relationship between human immunodeficiency virus (HIV) infection and mpox outcomes, particularly hospitalization rates, remains underexplored despite the known immunosuppressive effects of HIV. This systematic review and meta-analysis aimed to clarify the association between HIV infection and the likelihood of hospitalization in mpox cases.

METHODS: A literature search was conducted through PubMed, Embase, Web of Science, Scopus, and the Cochrane Library up until August 10, 2024. The eligibility criteria focused on observational studies that evaluated hospitalization rates among mpox cases, distinguishing between HIV-positive and HIV-negative individuals. Newcastle-Ottawa Scale was used for evaluating study quality. The meta-analysis used a random-effects model to accommodate expected study heterogeneity using R software (V. 4.4).

RESULTS: The search yielded 686 records, with 14 studies meeting the inclusion and exclusion criteria after screenings and full-text assessments. The pooled analysis revealed a 56.6% increased risk of hospitalization among HIV-positive mpox cases compared to HIV-negative individuals (95% CI: 18.0-107.7%). Notable heterogeneity (I² = 76%) was observed, likely reflecting variations in study settings and methodologies. Sensitivity analysis confirmed the robustness of these findings, and no significant publication bias was detected (Egger's test p-value = 0.733).

CONCLUSION: HIV infection is associated with a statistically significant increased risk of hospitalization in mpox cases. There is a critical need for integrated care and enhanced surveillance, especially in populations with high HIV prevalence. Our findings emphasize the importance of ongoing research to better understand HIV and mpox co-infection and to refine management strategies for this vulnerable group. Future studies should focus on long-term outcomes and the effectiveness of various management strategies across different healthcare settings.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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