Affiliations 

  • 1 Vasireddy Venkatadri Institute of Technology, Nambur, 522508, India
  • 2 School of Computing, Amrita Vishwa Vidyapeetham, Amaravati, 522503, India. madhu031083@gmail.com
  • 3 School of Computing, SASTRA Deemed University, Thanjavur, 613401, India
  • 4 Department of Software Engineering & Division of Electronics and Information Engineering, Jeonbuk National University, Jeonju-si, 54896, Republic of Korea. chojh@jbnu.ac.kr
  • 5 Department of Data Science and Artificial Intelligence, Sunway University, 47500, Petaling Jaya, Selangor Darul Ehsan, Malaysia
Sci Rep, 2025 Jan 27;15(1):3438.
PMID: 39870673 DOI: 10.1038/s41598-024-84255-w

Abstract

Precise segmentation of retinal vasculature is crucial for the early detection, diagnosis, and treatment of vision-threatening ailments. However, this task is challenging due to limited contextual information, variations in vessel thicknesses, the complexity of vessel structures, and the potential for confusion with lesions. In this paper, we introduce a novel approach, the MSMA Net model, which overcomes these challenges by replacing traditional convolution blocks and skip connections with an improved multi-scale squeeze and excitation block (MSSE Block) and Bottleneck residual paths (B-Res paths) with spatial attention blocks (SAB). Our experimental findings on publicly available datasets of fundus images, specifically DRIVE, STARE, CHASE_DB1, HRF and DR HAGIS consistently demonstrate that our approach outperforms other segmentation techniques, achieving higher accuracy, sensitivity, Dice score, and area under the receiver operator characteristic (AUC) in the segmentation of blood vessels with different thicknesses, even in situations involving diverse contextual information, the presence of coexisting lesions, and intricate vessel morphologies.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.