Fulltext

In Vitro and In Silico Antidiabetic Efficacy of Solanum lasiocarpum Dunal Fruit Extract

Zhao J 1 , Najm AA 1 , Mahmood I 2 , Ming ZY 3 , Dutta PP 4 , Talib WH 5 Show all authors , Law D 3 , Fazry S 1

Affiliations 

  • 1 Department of Food Science, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia
  • 2 Dentistry Department, Al-Rafidain University College, Baghdad, Iraq
  • 3 Faculty of Health and Life Sciences, Inti International University, Nilai, Negeri Sembilan, Malaysia
  • 4 Faculty of Pharmaceutical Science, Assam down town University, Panikhaiti, Guwahati, Assam, India
  • 5 Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan
PLoS One, 2025;20(3):e0312600.
PMID: 40063647 DOI: 10.1371/journal.pone.0312600

Abstract

Exploring the possibility of familiar dietary sources as additional diabetes treatments is crucial, especially considering the financial difficulties related to diabetes mellitus. Using both in vitro and in silico techniques, this work aims to assess the antidiabetic benefits of extract from Solanum lasiocarpum Dunal. The evaluations encompass the ability to scavenge DPPH radicals, inhibition of α-amylase, α-glucosidase, inhibition of DPP-4, cytotoxicity, and glucose absorption kinetics. With an IC50 value of 0.69 ±  0.14 mg/ml, S. lasiocarpum showed encouraging DPPH inhibition. IC50 values of 2.123 ±  0.14 mg/ml inhibited the enzymes α-amylase, α-glucosidase, and DPP-4. Furthermore, a notable increase (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications