Interfacial Engineering Enhancing Electron Transfer of CaF2 Nanoparticles for Periodontitis Treatment of Sonotherapy and Bone Resorption

Liu Q 1 , Wang Y 1 , Huang J 1 , Liu X 1 , Mao C 1 , Wang C 2 Show all authors , Zheng Y 3 , Liu H 4 , Lai KW 5 , Li Z 4 , Zhu S 4 , Jiang H 4 , Cui Z 4 , Wu S 1

Affiliations 

  • 1 School of Materials Science & Engineering, Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei University, Wuhan 430062, China
  • 2 School of Health Science & Biomedical Engineering, Hebei University of Technology, Tianjin 300401, China
  • 3 School of Materials Science & Engineering, Peking University, Beijing 100871, China
  • 4 School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China, Tianjin University, Tianjin 300072, China
  • 5 Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur 57000, Malaysia
ACS Nano, 2025 Mar 27.
PMID: 40145746 DOI: 10.1021/acsnano.5c01112

Abstract

Conventional periodontitis treatments can be superseded by sonodynamic therapy. In this study, a Zn(OH)F/CaF2 heterojunction was synthesized via a hydrothermal method, which exhibited good biocompatibility and antibacterial properties. The band gap decreased significantly after the formation of the heterojunction, thereby enhancing the internal electron transfer. In addition, after the bacteria contact with the material, the electrons of the electron transport chain turn to Zn(OH)F/CaF2 and affect its steady state. Ultimately, H2O2 in an inflammatory environment was used to react with Zn(OH)F/CaF2 to facilitate electron transfer under the influence of ultrasound, ultimately enhancing the catalytic activity. Zn(OH)F/CaF2 exhibits significant antibacterial efficacy against Porphyromonas gingivalis and Staphylococcus aureus. Trace elements Ca and Zn can promote tissue repair and osteogenic differentiation, resulting in less bone destruction and intact gingival tissue after periodontitis treatment. This sonodynamic therapy provides a rapid antibacterial, effective, and deep therapeutic method for treating periodontitis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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