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Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model

Qnais EY 1 , Barakat M 2 , Athamneh RY 3 , Al-Najjar MAA 4 , Alzaghari LF 2 , Chellappan DK 5 Show all authors , Alqudah A 6

Affiliations 

  • 1 Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan
  • 2 Department of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan
  • 3 Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, Jordan
  • 4 Department of Pharmaceutics and Pharmaceutical Sciences, Faculty of Pharmacy, Applied Science Private University, Amman, Jordan
  • 5 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia
  • 6 Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan
Future Sci OA, 2025 Dec;11(1):2483137.
PMID: 40162624 DOI: 10.1080/20565623.2025.2483137

Abstract

AIMS: To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin-administered alone and in combination-in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.

MATERIALS & METHODS: Oral doses of cytidine, uridine, and gabapentin (100 mg/kg each) were administered to rats with streptozotocin-induced diabetic neuropathy and in a formalin test model. Behavioral responses were recorded at 30, 60, and 120 minutes following treatment after five weeks of diabetes induction. Spinal cord p-CREB expression was measured to assess molecular changes, and pretreatments with naloxone, yohimbine, and methysergide were employed to explore opioid, adrenergic, and serotonergic contributions.

RESULTS: All treatments significantly reduced formalin-induced pain in both acute and inflammatory phases (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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