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Monitoring model drug microencapsulation in PLGA scaffolds using X-ray powder diffraction

Aina A 1 , Gupta M 2 , Boukari Y 3 , Morris A 3 , Billa N 3 , Doughty S 3

Affiliations 

  • 1 Department of Mathematics and Natural Science, American University of Iraq, Kirkuk Main Road, Raparin, Sulaimani, Iraq; Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
  • 2 Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia; School of Pharmacy, Monash University Malaysia Campus, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia
  • 3 Drug Delivery Laboratory, School of Pharmacy, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia
Saudi Pharm J, 2016 Mar;24(2):227-31.
PMID: 27013917 DOI: 10.1016/j.jsps.2015.03.015

Abstract

The microencapsulation of three model drugs; metronidazole, paracetamol and sulphapyridine into Poly (dl-Lactide-Co-Glycolide) (PLGA) scaffolds were probed using X-ray Powder Diffraction (XRPD). Changes in the diffraction patterns of the PLGA scaffolds after encapsulation was suggestive of a chemical interaction between the pure drugs and the scaffolds and not a physical intermixture.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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