Alcimaterpenoids A and B, Two Enantiomeric Pairs of Bis-Denudaquinol-Monoterpenoid Meroterpenoids from the Endangered Plant Alcimandra cathcartii

Wan J 1 , Xiao CY 2 , Jiang CX 1 , Wang C 1 , Tong YP 1 , Choo YM 3 Show all authors , Huang D 1 , Hu JF 1

Affiliations 

  • 1 Institute of Natural Medicine and Health Products, Key Laboratory of Endangered Plants Sustainable Utilization of Taizhou University, School of Pharmaceutical Sciences, Taizhou University, Zhejiang318000, PR China
  • 2 Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang330004, PR China
  • 3 Chemistry Department, Faculty of Science, University of Malaya, Kuala Lumpur50603, Malaysia
J Org Chem, 2026 Nov 03.
PMID: 42975970 DOI: 10.1021/acs.joc.6c01752

Abstract

Alcimaterpenoids A (1) and B (2), two pairs of racemic bis-denudaquinol-monoterpenoid meroterpenoids, were isolated and identified from Alcimandra cathcartii. Electronic circular dichroism (ECD) computations, GIAO 13C{1H} NMR (in conjunction with DP4+ probability analysis), and extensive 2D-NMR spectroscopic analysis techniques were used to determine their structures and absolute configurations. Structurally, compounds 1 and 2 are the first enantiomeric bis-denudaquinol-monoterpenoid meroterpenoids. Plausible biosynthetic pathways were briefly proposed. Compound (±)-1 exhibited moderate cytotoxic activity against the human PLC/PRF/5 cell line (IC50: 20.6 μM).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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