Cleistopholine isolated from Enicosanthellum pulchrum exhibits apoptogenic properties in human ovarian cancer cells

Nordin N 1 , Majid NA 2 , Mohan S 3 , Dehghan F 4 , Karimian H 1 , Rahman MA 1 Show all authors , Ali HM 5 , Hashim NM 6

Affiliations 

  • 1 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 2 Institute of Biological Science, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 3 Medical Research Center, Jazan University, Jazan, Saudi Arabia
  • 4 Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 5 Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 6 Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: najihahmh@gmail.com
Phytomedicine, 2016 Apr 15;23(4):406-16.
PMID: 27002411 DOI: 10.1016/j.phymed.2016.02.016

Abstract

Cleistopholine is a natural alkaloid present in plants with numerous biological activities. However, cleistopholine has yet to be isolated using modern techniques and the mechanism by which this alkaloid induces apoptosis in cancer cells remains to be elucidated.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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