Expression of zTOR-associated microRNAs in zebrafish embryo treated with rapamycin

Khor ES 1 , Noor SM 2 , Wong PF 3

Affiliations 

  • 1 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: darren_khor@hotmail.my
  • 2 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: suzita@um.edu.my
  • 3 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: wongpf@um.edu.my
Life Sci, 2016 Apr 1;150:67-75.
PMID: 26916825 DOI: 10.1016/j.lfs.2016.02.076

Abstract

MicroRNAs (miRNAs) are vital in modulating lifespan and various biological processes including vascular function. The pivotal roles of mammalian target of rapamycin (mTOR) in regulating senescence and angiogenesis have been extensively described. However, the roles of its orthologue, zebrafish target of rapamycin (zTOR) in senescence and angiogenesis remain to be unravelled. In the present study, we aimed to investigate the role of zTOR and identify miRNAs associated with senescence and angiogenesis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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