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Polymodal therapy for high grade gliomas: a case report of favourable outcomes following intraoperative radiation therapy

Zamzuri I 1 , Rahman GI 2 , Muzaimi M 3 , Jafri AM 4 , Nik Ruzman NI 5 , Lutfi YA 6 Show all authors , Biswal BM 7 , Nazaruddin HW 8 , Mar W 9

Affiliations 

  • 1 Zamzuri Idris, MS Neuro.Department of Neurosciences, School of Medical Sciences, Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. zamzuri@kb.usm.my
  • 2 G I Rahman, MS Neuro. Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
  • 3 M Muzaimi, PhD. Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
  • 4 A M Jafri, PhD. Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
  • 5 N I Nik Ruzman, MSc Physics. Department of Nuclear Medicine and Oncology, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
  • 6 Y A Lufti, PhD (Physics). Department of Nuclear Medicine and Oncology, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
  • 7 B M Biswal, DNB. Department of Nuclear Medicine and Oncology, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
  • 8 H W Nazaruddin, MMed (Anaes). Department of Anaesthesiology, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
  • 9 W Mar, MMed (Radio). Department of Radiology, School of Medical Sciences, Universiti Sains Malaysia,16150, Kubang Kerian, Kelantan, Malaysia.
Med J Malaysia, 2012 Feb;67(1):121-2.
PMID: 22582564 MyJurnal

Abstract

High grade gliomas, frequently with their infiltrative nature, often make the outcome from neurosurgical intervention alone unsatisfactory. It is recognized that adjuvant radiochemotherapy approaches offer an improved prognosis. For these reasons, we opted for surgical debulking, intraoperative radiation therapy (IORT) in combination with whole brain irradiation therapy and chemotherapy (temozolamide cycles) in the management of a 42 year-old lady with Glioblastoma Multiforme (GBM). Her troublesome symptoms improved after 3 months of this polymodal therapy and remained independently functional for more than two years.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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